2024 Vol. 14, No. 5

Short communication
Insights into Euphorbia diversity: Probing the contrasts between Euphorbia fischeriana Steud and Euphorbia ebracteolata Hayata
Kaicheng Du, Yi Zhang, Lei Sun, Muke Tao, Tiantian Zuo, Yumeng Wang, Zhengfeng Zhang, Dali Meng
2024, 14(5): 100896. doi: 10.1016/j.jpha.2023.11.003
Abstract:
Eco-friendly high-throughput screening of cephalosporins impurities: Utilizing 2D-carbon microfiber fractionation system combined with quadrupole time of flight high-resolution mass spectrometer
Lei Yang, Yan Wang, Zhao Wang, Meiyu Cui, Ruolan Jin, Hai-Bo Shang, Donghao Li
2024, 14(5): 100900. doi: 10.1016/j.jpha.2023.11.007
Abstract:
Original article
Ginsenoside Rb1 induces hepatic stellate cell ferroptosis to alleviate liver fibrosis via the BECN1/SLC7A11 axis
Lifan Lin, Xinmiao Li, Yifei Li, Zhichao Lang, Yeping Li, Jianjian Zheng
2024, 14(5): 100902. doi: 10.1016/j.jpha.2023.11.009
Abstract:
Liver fibrosis is primarily driven by the activation of hepatic stellate cells (HSCs), a process associated with ferroptosis. Ginsenoside Rb1 (GRb1), a major active component extracted from Panax ginseng, inhibits HSC activation. However, the potential role of GRb1 in mediating HSC ferroptosis remai...
Apatinib and gamabufotalin co-loaded lipid/Prussian blue nanoparticles for synergistic therapy to gastric cancer with metastasis
Binlong Chen, Yanzhong Zhao, Zichang Lin, Jiahao Liang, Jialong Fan, Yanyan Huang, Leye He, Bin Liu
2024, 14(5): 100904. doi: 10.1016/j.jpha.2023.11.011
Abstract:
Due to the non-targeted release and low solubility of anti-gastric cancer agent, apatinib (Apa), a first-line drug with long-term usage in a high dosage often induces multi-drug resistance and causes serious side effects. In order to avoid these drawbacks, lipid-film-coated Prussian blue nanoparticl...
Alginate oligosaccharide-mediated butyrate-HIF-1α axis improves skin aging in mice
Ting Gao, Yixuan Li, Xiaoyu Wang, Fazheng Ren
2024, 14(5): 100911. doi: 10.1016/j.jpha.2023.12.001
Abstract:
The “gut-skin” axis has been proved and is considered as a novel therapy for the prevention of skin aging. The antioxidant efficacy of oligomannonic acid (MAOS) makes it an intriguing target for use to improve skin aging. The present study further explored whereby MAOS-mediated gut-skin axis balance...
Measurement of very low-molecular weight metabolites by traveling wave ion mobility and its use in human urine samples
Alongkorn Kurilung, Suphitcha Limjiasahapong, Khwanta Kaewnarin, Pattipong Wisanpitayakorn, Narumol Jariyasopit, Kwanjeera Wanichthanarak, Sitanan Sartyoungkul, Stephen Choong Chee Wong, Nuankanya Sathirapongsasuti, Chagriya Kitiyakara, Yongyut Sirivatanauksorn, Sakda Khoomrung
2024, 14(5): 100921. doi: 10.1016/j.jpha.2023.12.011
Abstract:
The collision cross-sections (CCS) measurement using ion mobility spectrometry (IMS) in combination with mass spectrometry (MS) offers a great opportunity to increase confidence in metabolite identification. However, owing to the lack of sensitivity and resolution, IMS has an analytical challenge in...
Rapid discovery of a novel “green” and natural GST inhibitor for sensitizing hepatocellular carcinoma to Cisplatin by visual screening strategy
Linxi Mao, Yan Qin, Jialong Fan, Wei Yang, Bin Li, Liang Cao, Liqin Yuan, Mengyun Wang, Bin Liu, Wei Wang
2024, 14(5): 100923. doi: 10.1016/j.jpha.2023.12.013
Abstract:
Over-expression of glutathione S-transferase (GST) can promote Cisplatin resistance in hepatocellular carcinoma (HCC) treatment. Hence, inhibiting GST is an attractive strategy to improve Cisplatin sensitivity in HCC therapy. Although several synthesized GST inhibitors have been developed, the side ...
Cornus officinalis with high pressure wine steaming enhanced anti-hepatic fibrosis: Possible through SIRT3-AMPK axis
Xin Han, Yan Ning, Xinyue Dou, Yiwen Wang, Qiyuan Shan, Kao Shi, Zeping Wang, Chuan Ding, Min Hao, Kuilong Wang, Mengyun Peng, Haodan Kuang, Qiao Yang, Xianan Sang, Gang Cao
2024, 14(5): 100927. doi: 10.1016/j.jpha.2023.12.017
Abstract:
Cornus officinalis, a medicinal and edible plant known for its liver-nourishing properties, has shown promise in inhibiting the activation of hepatic stellate cells (HSCs), crucial indicators of hepatic fibrosis, especially when processed by high pressure wine steaming (HPWS). Herein, this study aim...
Discrimination of polysorbate 20 by high-performance liquid chromatography-charged aerosol detection and characterization for components by expanding compound database and library
Shi-Qi Wang, Xun Zhao, Li-Jun Zhang, Yue-Mei Zhao, Lei Chen, Jin-Lin Zhang, Bao-Cheng Wang, Sheng Tang, Tom Yuan, Yaozuo Yuan, Mei Zhang, Hian Kee Lee, Hai-Wei Shi
2024, 14(5): 100929. doi: 10.1016/j.jpha.2023.12.019
Abstract:
Analyzing polysorbate 20 (PS20) composition and the impact of each component on stability and safety is crucial due to formulation variations and individual tolerance. The similar structures and polarities of PS20 components make accurate separation, identification, and quantification challenging. I...
Review paper
Sonodynamic therapy for the treatment of atherosclerosis
Yan Zhang, Ying Yang, Yudi Feng, Xueyan Gao, Liping Pei, Xiaopan Li, Bingxin Gao, Lin Liu, Chengzeng Wang, Shuochen Gao
2024, 14(5): 100909. doi: 10.1016/j.jpha.2023.11.016
Abstract:
Atherosclerosis (AS) is a chronic inflammatory disease of large and medium-sized arteries that leads to ischemic heart disease, stroke, and peripheral vascular disease. Despite the current treatments, mortality and disability still remain high. Sonodynamic therapy (SDT), a non-invasive and localized...
New advances of adiponectin in regulating obesity and related metabolic syndromes
Yanqi Han, Qianwen Sun, Wei Chen, Yue Gao, Jun Ye, Yanmin Chen, Tingting Wang, Lili Gao, Yuling Liu, Yanfang Yang
2024, 14(5): 100913. doi: 10.1016/j.jpha.2023.12.003
Abstract:
Obesity and related metabolic syndromes have been recognized as important disease risks, in which the role of adipokines cannot be ignored. Adiponectin (ADP) is one of the key adipokines with various beneficial effects, including improving glucose and lipid metabolism, enhancing insulin sensitivity,...
GLP-1 receptor agonists and myocardial metabolism in atrial fibrillation
Jiani Zhong, Hang Chen, Qiming Liu, Shenghua Zhou, Zhenguo Liu, Yichao Xiao
2024, 14(5): 100917. doi: 10.1016/j.jpha.2023.12.007
Abstract:
Atrial fibrillation (AF) is the most common cardiac arrhythmia. Many medical conditions, including hypertension, diabetes, obesity, sleep apnea, and heart failure (HF), increase the risk for AF. Cardiomyocytes have unique metabolic characteristics to maintain adenosine triphosphate production. Signi...
Nitrosamines crisis in pharmaceuticals-Insights on toxicological implications, root causes and risk assessment: A systematic review
Hemanth P. R. Vikram, Tegginamath Pramod Kumar, Gunjan Kumar, Narasimha M. Beeraka, Rajashree Deka, Sheik Mohammed Suhail, Sandeep Jat, Namitha Bannimath, Gayatiri Padmanabhan, Ravandur S. Chandan, Pramod Kumar, Bannimath Gurupadayya
2024, 14(5): 100919. doi: 10.1016/j.jpha.2023.12.009
Abstract:
The presence of N-nitroso compounds, particularly N-nitrosamines, in pharmaceutical products has raised global safety concerns due to their significant genotoxic and mutagenic effects. This systematic review investigates their toxicity in active pharmaceutical ingredients (APIs), drug products, and ...