2013 Vol. 3, No. 6

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INFORMATION
Application of analytical instruments in pharmaceutical analysis
2013, (6): Ⅰ-Ⅳ.
Abstract(105) PDF(2)
Abstract:
ORIGINAL ARTICLE
Pharmacokinetic study of inosiplex tablets in healthy Chinese volunteers by hyphenated HPLC and tandem MS techniques
Mo Chen, Yuan Zhang, Xiao-Ting Que, Ya Ding, Lin Yang, Ai-Dong Wen, Tai-Jun Hang
2013, (6): 387-393.
Abstract(179) PDF(5)
Abstract:
Inosiplex is a compound formulation composed of inosine and p-acetaminobenzoic acid (PABA) salt of N,N-dimethylamino-2-propanol (DIP). This study was to investigate the clinical plasma pharmacokinetic properties of DIP and PABA after single and multiple oral doses of inosiplex tablets in healthy Chi...
Simultaneous determination of asenapine and valproic acid in human plasma using LC-MS/MS:Application of the method to support pharmacokinetic study
Ambavaram Vijaya Bhaskar Reddy, Nandigam Venugopal, Gajulapalle Madhavin
2013, (6): 394-401.
Abstract(61) PDF(4)
Abstract:
Combination of asenapine with valproic acid received regulatory approval for acute treatment of schizophrenia and maniac episodes of bipolar disorders. A simple LC-MS/MS method was developed and validated for simultaneous quantification of asenapine and valproic acid in human plasma. Internal standa...
Analysis on fat-soluble components of sinapis semina from different habitats by GC-MS
Cheng Peng, Tao Zhang, Gang Zhao, Sicen Wang
2013, (6): 402-407.
Abstract(118) PDF(2)
Abstract:
A simple and rapid gas chromatography/mass spectrometry (GC/MS) analysis method was developed for the determination of fat-soluble parts of sinapis semina. Four major compounds were chosen as marker compounds to evaluate the method. Various extraction techniques were evaluated and the greatest effic...
Rapid, simple and stability-indicating determination of polyhexamethylene biguanide in liquid and gel-like dosage forms by liquid chromatography with diode-array detection
Markus Küsters, S?ren Beyer, Stephan Kutscher, Harald Schlesinger, Michael Gerhartz
2013, (6): 408-414.
Abstract(109) PDF(2)
Abstract:
A rapid and simple method for the determination of polyhexamethylene biguanide (polyhexanide, PHMB) in liquid and gel-like pharmaceutical formulations by means of high performance liquid chromatography coupled to diode-array detection (HPLC-DAD) was developed. Best separation was achieved using a cy...
Determination of epristeride by its quenching effect on the fluorescence of L-tryptophan
Ai-Qin Gong, Xia-Shi Zhu
2013, (6): 415-420.
Abstract(184) PDF(2)
Abstract:
A rapid, novel spectrofluorimetric method to determine epristeride (EP) in biological fluids and a pharmaceutical formulation was developed, based on the fact that fluorescence intensity of L-tryptophan could be quenched by EP in the medium of pH ? 9.0. The various factors influencing fluorescence q...
Quantitative analysis of catechins in Saraca asoca and correlation with antimicrobial activity
Amey Shirolkar, Anjum Gahlaut, Anil K. Chhillar, Rajesh Dabur
2013, (6): 421-428.
Abstract(107) PDF(2)
Abstract:
Herbal medicines are highly complex and have unknown mechanisms in diseases treatment. Saraca asoca (Roxb.), De. Wild has been recommended to treat gynecological disorders and used in several commercial polyherbal formulations. In present study, efforts have been made to explore antimicrobial activi...
Preparative separation and purification of deoxyschizandrin from Schisandrae Sphenantherae Fructus by high-speed counter-current chromatography
Xin-Ying Li, Mei Yang, Jie-Yun Huang, Xiao-Xue Yu, Min-Qian Zhao, Zhi-Kun Liang, Zhi-Sheng Xie, Xin-Jun Xu
2013, (6): 429-433.
Abstract(134) PDF(2)
Abstract:
A high-speed counter-current chromatography (HSCCC) method was successfully developed for the preparative separation and purification of deoxyschizandrin from Schisandrae Sphenantherae Fructus in one step. The purity of deoxyschizandrin was 98.5%, and the structure was identified by MS, UV and NMR. ...
Optimization and validation of a fast RP-HPLC method for the determination of dobutamine in rat plasma:Pharmacokinetic studies in healthy rat subjects
Ramesh Thippani, Nageswara Rao Pothuraju, Nageswara Rao Ramisetti, Saida Shaik
2013, (6): 434-439.
Abstract(205) PDF(3)
Abstract:
A novel isocratic reverse phase high performance liquid chromatography (RP-HPLC) with photo diode array (PDA) detection method for the determination of dobutamine (DBT) in rat plasma was developed and validated after optimization of various chromatographic conditions and other experimental parameter...
Development and validation of an RP-HPLC method for simultaneous determination of Ramipril and Amlodipine in tablets
Shi-Ying Dai, Shi-Ting Qiu, Wei Wu, Chun-Mei Fu
2013, (6): 440-446.
Abstract(187) PDF(9)
Abstract:
An RP-HPLC method for the simultaneous determination of and Amlodipine (AL)Ramipril (RP) in tablets was developed and validated by Chinese Pharmacopoeia 2010. The linearity of the proposed method was investigated in the range of 0.01-0.25 mg/mL (r2 ? 0.9998) for RP and 0.014-0.36 mg/mL (r2 ? 0.9997)...
SHORT COMMUNICATION
Simultaneous determination of five diterpenoid alkaloids in Herba Delphinii by HPLC/ELSD
Chao-Zhan Lin, Si-Min Xie, Chen-Chen Zhu, Zeren-Dawa Bairu, Suolang-Qimei Kangsa, Dun Zhu
2013, (6): 447-451.
Abstract(94) PDF(3)
Abstract:
A HPLC-ELSD method was developed and validated for simultaneous determination of five Hetisane-type diterpenoid alkaloids in a Tibetan traditional herbal medicine, “Gebu Dilu” (Herba Delphinii), using a Kromasil C18 column (250 mm ? 4.6 mm, 5μm) with the mobile phase consisting of acetonitrile and 0...
Voltammetric quantitation of nitazoxanide by glassy carbon electrode
Rajeev Jain, Rajeev Kumar Yadav, Jahangir Ahmad Rather
2013, (6): 452-455.
Abstract(125) PDF(2)
Abstract:
The present study reports voltammetric reduction of nitazoxanide in Britton-Robinson (B-R) buffer by cyclic and square-wave voltammetry at glassy carbon electrode. A versatile fully validated voltammetric method for quantitative determination of nitazoxanide in pharmaceutical formulation has been pr...
Preparative isolation of Heteroclitin D from Kadsurae Caulis using normal-phase flash chromatography
Xiao-Xue Yu, Qian-Wen Wang, Xin-Jun Xu, Wei-Jian Lv, Ming-Qian Zhao, Zhi-Kun Liang
2013, (6): 456-459.
Abstract(102) PDF(2)
Abstract:
Heteroclitin D (H.D) was successfully isolated from Kadsurae Caulis by using flash chromatography and recrystallized by methanol, 10.2 mg of H.D was obtained from 4.86 g of crude extract, and the purity determined by HPLC was 99.4%. The structure was identified by UV, IR, MS, and NMR analysis. The f...

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