2014 Vol. 4, No. 1

Display Method:
REVIEW ARTICLE
Measurement uncertainty in pharmaceutical analysis and its application
Marcus Augusto Lyrio Traple, Alessandro Morais Saviano, Fabiane Lacerda Francisco, Felipe Rebello Louren?on
2014, (1): 1-5.
Abstract(131) PDF(4)
Abstract:
The measurement uncertainty provides complete information about an analytical result. This is very important because several decisions of compliance or non-compliance are based on analytical results in pharmaceutical industries. The aim of this work was to evaluate and discuss the estimation of unce...
ORIGINAL ARTICLE
Metabolic profiling of plasma from cardiac surgical patients concurrently administered with tranexamic acid:DI-SPME-LC-MS analysis
Barbara Bojko, Marcin W?sowicz, Janusz Pawliszyn
2014, (1): 6-13.
Abstract(122) PDF(3)
Abstract:
A metabolic profile of plasma samples from patients undergoing heart surgery with the use of cardiopulmonary bypass (CPB) and concurrent administration of tranexamic acid was determined. Direct immersion solid phase microextraction (DI-SPME), a new sampling and sample preparation tool for metabolomi...
Identification of metabolites of Radix Paeoniae Alba extract in rat bile, plasma and urine by ultra-performance liquid chromatography-quadrupole time-of-flight mass spectrometry
Zheng-Wei Chen, Ling Tong, Shu-Ming Li, Dong-Xiang Li, Ying Zhang, Shui-Ping Zhou, Yong-Hong Zhu, He Sun
2014, (1): 14-25.
Abstract(153) PDF(2)
Abstract:
Ultra-performance liquid chromatography coupled with quadrupole time-of-flight tandem mass spectrometry (UPLC-Q-TOF/MS) was developed to identify the absorbed parent components and metabolites in rat bile, plasma and urine after oral administration of Radix Paeoniae Alba extract (RPAE). A total of 6...
Simultaneous quantitation of atorvastatin and its two active metabolites in human plasma by liquid chromatography/(-) electrospray tandem mass spectrometry
Pankaj Partani, S. Manaswita Verma, Sanjay Gurule, Arshad Khuroo, Tausif Monif
2014, (1): 26-36.
Abstract(149) PDF(3)
Abstract:
A sensitive, accurate and selective liquid chromatography-tandem mass spectrometry method (LC-MS/MS) was developed and validated for the simultaneous quantitation of atorvastatin (AT) and its equipotent hydroxyl metabolites, 2-hydroxy atorvastatin (2-AT) and 4-hydroxy atorvastatin (4-AT), in human p...
LC-UV/MS quality analytics of paediatric artemether formulations
Kirsten Vandercruyssen, Matthias D’Hondt, Valentijn Vergote, Herwig Jansen, Christian Burvenich, Bart De Spiegeleer
2014, (1): 37-52.
Abstract(163) PDF(0)
Abstract:
A highly selective and stability-indicating HPLC-method, combined with appropriate sample preparation steps, is developed for β-artemether assay and profiling of related impurities, including possible degradants, in a complex powder for oral suspension. Following HPLC conditions allowed the required...
Comparative pharmacokinetics of five saponins after intravenous administration of TSFS injection and TSFS injection plus TFFG in rats under different physiological states
Xiao-Ming Liu, Xing Zhao, En-Ze Gao, Yun-Li Zhao, Zheng Liu, Zhi-Guo Yu
2014, (1): 53-62.
Abstract(128) PDF(1)
Abstract:
Sanqi is a popular traditional Chinese medicine and commonly used for promoting blood circulation and removing blood stasis. Notoginsenoside R1, ginsenoside Rg1, Re, Rb1 and Rd are the major active constituents of Sanqi. The purpose of the study was to investigate the pharmacokinetic behavior of the...
Development of a sensitive and rapid method for quantitation of (S)-(-)- and (R)-(t)-metoprolol in human plasma by chiral LC-ESI-MS/MS
Primal Sharma, Pritesh Contractor, Swati Guttikar, Daxesh P. Patel, Pranav S. Shrivastav
2014, (1): 63-79.
Abstract(97) PDF(0)
Abstract:
A selective, sensitive and high throughput liquid chromatography-tandem mass spectro-metry (LC-ESI-MS/MS) method has been developed for separation and quantification of metoprolol enantiomers on a chiral Lux Amylose-2 (250 mm×4.6 mm, 5 mm) column. Solid phase extraction of (S)-(-)- and (R)-(t)-metop...
INFORMATION
Application of analytical instruments in pharmaceutical analysis
2014, (1): 80-81.
Abstract(131) PDF(1)
Abstract: