2025 Vol. 15, No. 2

News
Holistic integrative medicine declaration
Daiming Fan
2025, 15(2): 101230. doi: 10.1016/j.jpha.2025.101230
Abstract:
Commentary
Comment on “Integration of deep neural network modeling and LC-MS-based pseudo-targeted metabolomics as a practical strategy to differentiate ginseng species”
Li Ping
2025, 15(2): 101231. doi: 10.1016/j.jpha.2025.101231
Abstract:
Review paper
Application of spectroscopic technology with machine learning in Chinese herbs from seeds to medicinal materials: The case of genus Paris
Yangna Feng, Xinyan Zhu, Yuanzhong Wang
2025, 15(2): 101103. doi: 10.1016/j.jpha.2024.101103
Abstract:

To ensure the safety and efficacy of Chinese herbs, it is of great significance to conduct rapid quality detection of Chinese herbs at every link of their supply chain. Spectroscopic technology can reflect the overall chemical composition and structural characteristics of Chinese herbs, with the mul...

Application of lipidomics in the study of traditional Chinese medicine
Yang Yang, Guangyi Yang, Wenpeng Zhang, Lingyi Xin, Jing Zhu, Hangtian Wang, Baodong Feng, Renyan Liu, Shuya Zhang, Yuanwu Cui, Qinhua Chen, Dean Guo
2025, 15(2): 101083. doi: 10.1016/j.jpha.2024.101083
Abstract:

Lipidomics is an emerging discipline that systematically studies the various types, functions, and metabolic pathways of lipids within living organisms. This field compares changes in diseases or drug impact, identifying biomarkers and molecular mechanisms present in lipid metabolic networks across ...

Exploring the potential protective role of anthocyanins in mitigating micro/nanoplastic-induced reproductive toxicity: A steroid receptor perspective
Jiaojiao Zhang, Wenyi Liu, Fuqiang Cui, Marjukka Kolehmainen, Jing Chen, Lei Zhang, Iman Zarei
2025, 15(2): 101148. doi: 10.1016/j.jpha.2024.101148
Abstract:

Microplastics and nanoplastics (MPs/NPs) are ubiquitous environmental pollutants that act as endocrine-disrupting chemicals (EDCs), raising significant concerns about their impact on human health. Research highlights the hazardous effects of MPs/NPs on both male and female reproductive systems, infl...

Natural products based on Correa's cascade for the treatment of gastric cancer trilogy: Current status and future perspective
Wenhao Liao, Jing Wang, Yuchen Li
2025, 15(2): 101075. doi: 10.1016/j.jpha.2024.101075
Abstract:

Gastric carcinoma (GC) is a malignancy with multifactorial involvement, multicellular regulation, and multistage evolution. The classic Correa's cascade of intestinal GC specifies a trilogy of malignant transformation of the gastric mucosa, in which normal gastric mucosa gradually progresses from in...

Exosomal circRNAs: Deciphering the novel drug resistance roles in cancer therapy
Xi Li, Hanzhe Liu, Peiyu Xing, Tian Li, Yi Fang, Shuang Chen, Siyuan Dong
2025, 15(2): 101067. doi: 10.1016/j.jpha.2024.101067
Abstract:

Exosomal circular RNA (circRNAs) are pivotal in cancer biology, and tumor pathophysiology. These stable, non-coding RNAs encapsulated in exosomes participated in cancer progression, tumor growth, metastasis, drug sensitivity and the tumor microenvironment (TME). Their presence in bodily fluids posit...

Mitochondria and myocardial ischemia/reperfusion injury: Effects of Chinese herbal medicine and the underlying mechanisms
Chuxin Zhang, Xing Chang, Dandan Zhao, Yu He, Guangtong Dong, Lin Gao
2025, 15(2): 101051. doi: 10.1016/j.jpha.2024.101051
Abstract:

Ischemic heart disease (IHD) is associated with high morbidity and mortality rates. Reperfusion therapy is the best treatment option for this condition. However, reperfusion can aggravate myocardial damage through a phenomenon known as myocardial ischemia/reperfusion (I/R) injury, which has recently...

Advances and mechanisms of traditional Chinese medicine and its active ingredients against antibiotic-resistant Escherichia coli infections
Shuo Yang, Ping Su, Lu Li, Shuang Liu, Yi Wang
2025, 15(2): 101117. doi: 10.1016/j.jpha.2024.101117
Abstract:

In clinical practice, antibiotics have historically been utilized for the treatment of pathogenic bacteria. However, the gradual emergence of antibiotic resistance among bacterial strains has posed a significant challenge to this approach. In 2022, Escherichia coli, a Gram-negative bacterium renowne...

Original article
Coupling of an Au@AgPt nanozyme array with an micrococcal nuclease-specific responsiveness strategy for colorimetric/SERS sensing of Staphylococcus aureus in patients with sepsis
Xueqin Huang, Yingqi Yang, Hanlin Zhou, Liping Hu, Annan Yang, Hua Jin, Biying Zheng, Jiang Pi, Jun Xu, Pinghua Sun, Huai-Hong Cai, Xujing Liang, Bin Pan, Junxia Zheng, Haibo Zhou
2025, 15(2): 101085. doi: 10.1016/j.jpha.2024.101085
Abstract:

Rapid and ultrasensitive detection of pathogen-associated biomarkers is vital for the early diagnosis and therapy of bacterial infections. Herein, we developed a close-packed and ordered Au@AgPt array coupled with a cascade triggering strategy for surface-enhanced Raman scattering (SERS) and colorim...

Targeted screening and profiling of massive components of colistimethate sodium by two-dimensional-liquid chromatography-mass spectrometry based on self-constructed compound database
Xuan Li, Minwen Huang, Yue-Mei Zhao, Wenxin Liu, Nan Hu, Jie Zhou, Zi-Yi Wang, Sheng Tang, Jian-Bin Pan, Hian Kee Lee, Yao-zuo Yuan, Taijun Hang, Hai-Wei Shi, Hongyuan Chen
2025, 15(2): 101072. doi: 10.1016/j.jpha.2024.101072
Abstract:

In-depth study of the components of polymyxins is the key to controlling the quality of this class of antibiotics. Similarities and variations of components present significant analytical challenges. A two-dimensional (2D) liquid chromatography-mass spectrometry (LC-MS) method was established for sc...

Supramolecular prodrug inspiried by the Rhizoma Coptidis-Fructus Mume herbal pair alleviated inflammatory diseases by inhibiting pyroptosis
Wenhui Qian, Bei Zhang, Ming Gao, Yuting Wang, Jiachen Shen, Dongbing Liang, Chao Wang, Wei Wei, Xing Pan, Qiuying Yan, Dongdong Sun, Dong Zhu, Haibo Cheng
2025, 15(2): 101056. doi: 10.1016/j.jpha.2024.101056
Abstract:

Sustained inflammatory responses are closely related to various severe diseases, and inhibiting the excessive activation of inflammasomes and pyroptosis has significant implications for clinical treatment. Natural products have garnered considerable concern for the treatment of inflammation. Huangli...

Natural product virtual-interact-phenotypic target characterization: A novel approach demonstrated with Salvia miltiorrhiza extract
Rui Xu, Hengyuan Yu, Yichen Wang, Boyu Li, Yong Chen, Xuesong Liu, Tengfei Xu
2025, 15(2): 101101. doi: 10.1016/j.jpha.2024.101101
Abstract:

Natural products (NPs) have historically been a fundamental source for drug discovery. Yet the complex nature of NPs presents substantial challenges in pinpointing bioactive constituents, and corresponding targets. In the present study, an innovative natural product virtual screening-interaction-phe...

Ginger protects against vein graft remodeling by precisely modulating ferroptotic stress in vascular smooth muscle cell dedifferentiation
Xiaoyu Yu, Weiwei Wu, Jingjun Hao, Yuxin Zhou, Deyang Yu, Wei Ding, Xuejuan Zhang, Gaoli Liu, Jianxun Wang
2025, 15(2): 101053. doi: 10.1016/j.jpha.2024.101053
Abstract:

Vein graft (VG) failure (VGF) is associated with VG intimal hyperplasia, which is characterized by abnormal accumulation of vascular smooth muscle cells (VSMCs). Most neointimal VSMCs are derived from pre-existing VSMCs via a process of VSMC phenotypic transition, also known as dedifferentiation. Th...

Hemodynamic disturbance and mTORC1 activation: Unveiling the biomechanical pathogenesis of thoracic aortic aneurysms in Marfan syndrome
Ming-Yuan Liu, Meili Wang, Junjun Liu, An-Qiang Sun, Chang-Shun He, Xin Cong, Wei Kong, Wei Li
2025, 15(2): 101120. doi: 10.1016/j.jpha.2024.101120
Abstract:

Thoracic aortic aneurysm (TAA) significantly endangers the lives of individuals with Marfan syndrome (MFS), yet the intricacies of their biomechanical origins remain elusive. Our investigation delves into the pivotal role of hemodynamic disturbance in the pathogenesis of TAA, with a particular empha...

Short communication
An economical and flexible chip using surface-enhanced infrared absorption spectroscopy for pharmaceutical detection: Combining qualitative analysis and quantitative detection
Jikai Wang, Pengfei Zeng, Haitao Xie, Suisui He, Xilin Xiao, Cuiyun Yu
2025, 15(2): 101076. doi: 10.1016/j.jpha.2024.101076
Abstract:
Permeable polydimethylsiloxane microneedles for the delivery of traditional Chinese medicine elemene
Qingchang Tian, Mengmeng Liu, Yiqiu Wang, Zhaoming Li, Daizhou Zhang, Tian Xie, Shuling Wang
2025, 15(2): 101094. doi: 10.1016/j.jpha.2024.101094
Abstract:
Identification of the fruit of Brucea javanica as an anti-liver fibrosis agent working via SMAD2/SMAD3 and JAK1/STAT3 signaling pathways
Di Yan, Liansheng Qiao, Wenting Huang, Xiaoling Zhang, Chengmei Ma, Quansheng Feng, Jing Cheng, Lan Xie
2025, 15(2): 101047. doi: 10.1016/j.jpha.2024.101047
Abstract:
Radiosynthesis and preclinical evaluation of [18F]AlF-labeled HBED-CC-FAPI derivatives for imaging of cancer-associated fibroblasts
Haiyan Hong, Yan Zhang, Jinping Qiao, Wensheng Zhang, Lin Zhu, Jiehua Xu
2025, 15(2): 101107. doi: 10.1016/j.jpha.2024.101107
Abstract: