Xi Li, Hanzhe Liu, Peixu Xing, Tian Li, Yi Fang, Shuang Chen, Siyuan Dong. Exosomal circRNAs: Deciphering the novel drug resistance roles in cancer therapy[J]. Journal of Pharmaceutical Analysis. doi: 10.1016/j.jpha.2024.101067
Citation:
Xi Li, Hanzhe Liu, Peixu Xing, Tian Li, Yi Fang, Shuang Chen, Siyuan Dong. Exosomal circRNAs: Deciphering the novel drug resistance roles in cancer therapy[J]. Journal of Pharmaceutical Analysis. doi: 10.1016/j.jpha.2024.101067
Xi Li, Hanzhe Liu, Peixu Xing, Tian Li, Yi Fang, Shuang Chen, Siyuan Dong. Exosomal circRNAs: Deciphering the novel drug resistance roles in cancer therapy[J]. Journal of Pharmaceutical Analysis. doi: 10.1016/j.jpha.2024.101067
Citation:
Xi Li, Hanzhe Liu, Peixu Xing, Tian Li, Yi Fang, Shuang Chen, Siyuan Dong. Exosomal circRNAs: Deciphering the novel drug resistance roles in cancer therapy[J]. Journal of Pharmaceutical Analysis. doi: 10.1016/j.jpha.2024.101067
a Department of Vascular and Thyroid Surgery, the First Hospital of China Medical University, Shenyang 110001, People's Republic of China;
b Department of Critical Care Medicine, Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute, Shenyang 110042, People's Republic of China;
c Department of Ophthalmology, China Medical University the Fourth People's Hospital, Shenyang 110031, People's Republic of China;
d School of Basic Medicine, the Fourth Military Medical University, Xi'an 710032, People's Republic of China;
e Department of Ultrasound, the First Hospital of China Medical University, Shenyang 110001, People's Republic of China;
f Department of Cardiology, the First Hospital of China Medical University, Shenyang 110001, People's Republic of China;
g Department of Thoracic Surgery, the First Hospital of China Medical University, Shenyang 110001, People's Republic of China
Exosomal circRNAs are pivotal in cancer biology, and tumor pathophysiology. These stable, non-coding RNAs encapsulated in exosomes participated in cancer progression, tumor growth, metastasis, drug sensitivity and the tumor microenvironment (TME). Their presence in bodily fluids positions them as potential non-invasive biomarkers, revealing the molecular dynamics of cancers. Research in exosomal circRNAs is reshaping our understanding of neoplastic intercellular communication. Exploiting the natural properties of exosomes for targeted drug delivery and disrupting circRNA-mediated pro-tumorigenic signaling can develop new treatment modalities. Therefore, ongoing exploration of exosomal circRNAs in cancer research is poised to revolutionize clinical management of cancer. This emerging field offers hope for significant breakthroughs in cancer care. This review underscores the critical role of exosomal circRNAs in cancer biology and drug resistance, highlighting their potential as non-invasive biomarkers and therapeutic targets that could transform the clinical management of cancer.