Hemodynamic Disturbance and mTORC1 Activation: Unveiling the Biomechanical Pathogenesis of Thoracic Aortic Aneurysms in Marfan Syndrome

doi: 10.1016/j.jpha.2024.101120

• MingYuan Liu^1,2 , 
• Meili Wang³ , 
• JunjunLiu⁴ , 
• AnQiang Sun⁵ , 
• ChangShun He² , 
• Xin Cong^6,7 , 
• Wei Kong^6,7 , 
• Wei Li^{2,7 ,  ,} 

• 1 Department of Vascular Surgery, Beijing Friendship Hospital, Capital Medical University;Beijing Center of Vascular Surgery, Beijing, 100050, China;

• 2 Department of Vascular Surgery, Peking University People's Hospital, Beijing, 100044, China;

• 3 Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Capital Medical University, Beijing, 100069, China;

• 4 Department of Vascular Surgery, The Affiliated hospital of Qingdao University, Qingdao, 266000, Shandong, China;

• 5 School of Biological Science and Medical Engineering, Beihang University, Beijing, 100083, China;

• 6 Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University, Beijing, 100191, China;

• 7 The Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing, 100191, China