Suppression of LIF in tumor-associated macrophages contributing to the PD-1/PD-L1 blockade in hepatocellular carcinoma

doi: 10.1016/j.jpha.2025.101286

• Shuangshuang Yin^a,b , 
• Yanming Luo^a,b , 
• Miaomiao Jiang^a,b , 
• Lifeng Han^a,b , 
• Sibao Chen^c , 
• Leilei Fu^{d ,  ,}  , 
• Yuling Qiu^{e ,  ,}  , 
• Haiyang Yu^{a,b ,  ,} 

• a. National Key Laboratory of Chinese Medicine Modernization, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China;

• b. Haihe Laboratory of Modern Chinese Medicine, Tianjin, 301617, China;

• c. State Key Laboratory of Chinese Medicine and Molecular Pharmacology (Incubation), Shenzhen, Department of Applied Biology and Chemical Technology, Research Center for Chinese Medicine Innovation, The Hong Kong Polytechnic University, Hong Kong, 999077, China;

• d. Sichuan Engineering Research Center for Biomimetic Synthesis of Natural Drugs, School of Life Science and Engineering, Southwest Jiaotong University, Chengdu, 610031, China;

• e. School of Pharmacy, Tianjin Medical University, Tianjin, 300070, China