Shuo Xiang, Arshad Khan, Qiufang Yao, Dong Wang. Recent Advances in Bacterial Outer Membrane Vesicles: Effects on the Immune System, Mechanisms and their Usage for Tumor Treatment[J]. Journal of Pharmaceutical Analysis. doi: 10.1016/j.jpha.2024.101049
Citation:
Shuo Xiang, Arshad Khan, Qiufang Yao, Dong Wang. Recent Advances in Bacterial Outer Membrane Vesicles: Effects on the Immune System, Mechanisms and their Usage for Tumor Treatment[J]. Journal of Pharmaceutical Analysis. doi: 10.1016/j.jpha.2024.101049
Shuo Xiang, Arshad Khan, Qiufang Yao, Dong Wang. Recent Advances in Bacterial Outer Membrane Vesicles: Effects on the Immune System, Mechanisms and their Usage for Tumor Treatment[J]. Journal of Pharmaceutical Analysis. doi: 10.1016/j.jpha.2024.101049
Citation:
Shuo Xiang, Arshad Khan, Qiufang Yao, Dong Wang. Recent Advances in Bacterial Outer Membrane Vesicles: Effects on the Immune System, Mechanisms and their Usage for Tumor Treatment[J]. Journal of Pharmaceutical Analysis. doi: 10.1016/j.jpha.2024.101049
a Center for AIE Research, Shenzhen Key Laboratory of Polymer Science and Technology, Guangdong Research Center for Interfacial Engineering of Functional Materials, College of Materials Science and Engineering, Shenzhen University, Shenzhen 518060, China
b College of Advanced Materials Engineering, Jiaxing Nanhu University, 572 Yuexiu Road, Jiaxing 314001, China
c Nanomedicine Department, King Abdullah International Medical Research Center (KAIMRC), King Saud bin Abdulaziz University for Health Sciences, Ministry of National Guard Health Affairs, Riyadh, 11426 Kingdom of Saudi Arabia
Funds:
This work was partially supported by the National Natural Science Foundation of China (52122317, 22175120), the Science and Technology Foundation of Shenzhen City (RCYX20200714114525101, 20220809130438001), the Pearl River Talent Recruitment Program (2019QN01Y103), the Medical-Engineering Interdisciplinary Research Foundation of Shenzhen University (2023YG021), the Research Team Cultivation Program of Shenzhen University (2023QNT003), the Jiaxing Public Welfare Research Program Project (2023AY11018), A Project Supported by Scientific Research Fund of Zhejiang Provincial Education Department (Y202352075), the Shenzhen Science and Technology Program (JCYJ20210324142211031), and A.K thanks the research support by King Abdullah International Medical Research Center (KAIMRC) through start up grant SF23/006/R.
Tumor treatment remains a significant medical challenge, with many traditional therapies causing notable side effects. Recent research has led to the development of immunotherapy, which offers numerous advantages. Bacteria inherently possess motility, allowing them to preferentially colonize tumors and modulate the tumor immune microenvironment, thus influencing the efficacy of immunotherapy. Bacterial outer membrane vesicles (OMVs) secreted by gram-negative bacteria, are nanoscale lipid bilayer structures rich in bacterial antigens, pathogenassociated molecular patterns (PAMPs), various proteins, and vesicle structures. These features allow OMVs to stimulate immune system activation, generate immune responses, and serve as efficient drug delivery vehicles. This dual capability enhances the effectiveness of immunotherapy combined with chemotherapy or phototherapy, thereby improving anticancer drug efficacy. Current research has concentrated on engineering OMVs to enhance production yield, minimize cytotoxicity, and improve the safety and efficacy of treatments. Consequently, OMVs hold great promise for applications in tumor immunotherapy, tumor vaccine development, and drug delivery. This article provides an overview of the structural composition and immune mechanisms of OMVs, details various OMVs modification strategies, and reviews the progress in using OMVs for tumor treatment and their anti-tumor mechanisms. Additionally, it discusses the challenges faced in translating OMV-based anti-tumor therapies into clinical practice, aiming to provide a comprehensive understanding of OMVs' potential for in-depth research and clinical application.