SPME as a green sample-preparation technique for the monitoring of phytocannabinoids and endocannabinoids in complex matrices

Katarzyna Wo&#378;niczka; Pawe&#322; Konieczy&#324;ski; Alina Plenis; Tomasz B&#261;czek; Anna Roszkowska

doi:10.1016/j.jpha.2023.06.014

Volume 13 Issue 10

Oct. 2023

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Katarzyna Woźniczka, Paweł Konieczyński, Alina Plenis, Tomasz Bączek, Anna Roszkowska. SPME as a green sample-preparation technique for the monitoring of phytocannabinoids and endocannabinoids in complex matrices[J]. Journal of Pharmaceutical Analysis, 2023, 13(10): 1117-1134. doi: 10.1016/j.jpha.2023.06.014

Citation:

Katarzyna Woźniczka, Paweł Konieczyński, Alina Plenis, Tomasz Bączek, Anna Roszkowska. SPME as a green sample-preparation technique for the monitoring of phytocannabinoids and endocannabinoids in complex matrices[J]. Journal of Pharmaceutical Analysis, 2023, 13(10): 1117-1134. doi: 10.1016/j.jpha.2023.06.014

Citation:

Katarzyna Woźniczka, Paweł Konieczyński, Alina Plenis, Tomasz Bączek, Anna Roszkowska. SPME as a green sample-preparation technique for the monitoring of phytocannabinoids and endocannabinoids in complex matrices[J]. Journal of Pharmaceutical Analysis, 2023, 13(10): 1117-1134. doi: 10.1016/j.jpha.2023.06.014

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SPME as a green sample-preparation technique for the monitoring of phytocannabinoids and endocannabinoids in complex matrices

doi: 10.1016/j.jpha.2023.06.014

a. Department of Pharmaceutical Chemistry, Medical University of Gdańsk, Gdańsk, Poland;
b. Department of Analytical Chemistry, Medical University of Gdańsk, Gdańsk, Poland

Received Date: Apr. 23, 2023
Accepted Date: Jun. 27, 2023
Rev Recd Date: Jun. 10, 2023
Publish Date: Oct. 30, 2023

Abstract

Abstract

The endocannabinoid system (ECS), particularly its signaling pathways and ligands, has garnered considerable interest in recent years. Along with clinical work investigating the ECS’ functions, including its role in the development of neurological and inflammatory conditions, much research has focused on developing analytical protocols enabling the precise monitoring of the levels and metabolism of the most potent ECS ligands: exogenous phytocannabinoids (PCs) and endogenous cannabinoids (endocannabinoids, ECs). Solid-phase microextraction (SPME) is an advanced, non-exhaustive sample-preparation technique that facilitates the precise and efficient isolation of trace amounts of analytes, thus making it appealing for the analysis of PCs and ECs in complex matrices of plant and animal/human origin. In this paper, we review recent forensic medicine and toxicological studies wherein SPME has been applied to monitor levels of PCs and ECs in complex matrices, determine their effects on organism physiology, and assess their role in the development of several diseases.
- Phytocannabinoids,
- Endocannabinoids,
- Solid-phase microextraction,
- Plant material,
- Biological matrix

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References(104)

References

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