Volume 13 Issue 10
Oct.  2023
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Zixi Zhang, Yongguo Dai, Yichao Xiao, Qiming Liu. Protective effects of catalpol on cardio-cerebrovascular diseases: A comprehensive review[J]. Journal of Pharmaceutical Analysis, 2023, 13(10): 1089-1101. doi: 10.1016/j.jpha.2023.06.010
Citation: Zixi Zhang, Yongguo Dai, Yichao Xiao, Qiming Liu. Protective effects of catalpol on cardio-cerebrovascular diseases: A comprehensive review[J]. Journal of Pharmaceutical Analysis, 2023, 13(10): 1089-1101. doi: 10.1016/j.jpha.2023.06.010

Protective effects of catalpol on cardio-cerebrovascular diseases: A comprehensive review

doi: 10.1016/j.jpha.2023.06.010

This work was supported by the National Natural Science Foundation of China (Grant Nos:. 82070356 and 81770337), the Key Project of Hunan Provincial Science and Technology Innovation, China (Grant No.: 2020SK1013), and the Hunan Provincial Natural Science Foundation of China (Grant No.: 2021JJ30033).

  • Received Date: Mar. 20, 2023
  • Accepted Date: Jun. 20, 2023
  • Rev Recd Date: May 15, 2023
  • Publish Date: Oct. 30, 2023
  • Catalpol, an iridoid glucoside isolated from Rehmannia glutinosa, has gained attention due to its potential use in treating cardio-cerebrovascular diseases (CVDs). This extensive review delves into recent studies on catalpol's protective properties in relation to various CVDs, such as atherosclerosis, myocardial ischemia, infarction, cardiac hypertrophy, and heart failure. The review also explores the compound's anti-oxidant, anti-inflammatory, and anti-apoptotic characteristics, emphasizing the role of vital signaling pathways, including PGC-1α/TERT, PI3K/Akt, AMPK, Nrf2/HO-1, estrogen receptor (ER), Nox4/NF-κB, and GRP78/PERK. The article discusses emerging findings on catalpol's ability to alleviate diabetic cardiovascular complications, thrombosis, and other cardiovascular-related conditions. Although clinical studies specifically addressing catalpol's impact on CVDs are scarce, the compound's established safety and well-tolerated nature suggest that it could be a valuable treatment alternative for CVD patients. Further investigation into catalpol and related iridoid derivatives may unveil new opportunities for devising natural and efficacious CVD therapies.
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