Compatibility and stability studies involving polymers used in fused deposition modeling 3D printing of medicines

Ihatanderson A. Silva; Ana Luiza Lima; Tais Gratieri; Guilherme M. Gelfuso; Livia L. Sa-Barreto; Marcilio Cunha-Filho

doi:10.1016/j.jpha.2021.09.010

Volume 12 Issue 3

Jun. 2022

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Article Navigation > Journal of Pharmaceutical Analysis > 2022 > 12(3): 424-435

Ihatanderson A. Silva, Ana Luiza Lima, Tais Gratieri, Guilherme M. Gelfuso, Livia L. Sa-Barreto, Marcilio Cunha-Filho. Compatibility and stability studies involving polymers used in fused deposition modeling 3D printing of medicines[J]. Journal of Pharmaceutical Analysis, 2022, 12(3): 424-435. doi: 10.1016/j.jpha.2021.09.010

Citation:

Ihatanderson A. Silva, Ana Luiza Lima, Tais Gratieri, Guilherme M. Gelfuso, Livia L. Sa-Barreto, Marcilio Cunha-Filho. Compatibility and stability studies involving polymers used in fused deposition modeling 3D printing of medicines[J]. Journal of Pharmaceutical Analysis, 2022, 12(3): 424-435. doi: 10.1016/j.jpha.2021.09.010

Citation:

Ihatanderson A. Silva, Ana Luiza Lima, Tais Gratieri, Guilherme M. Gelfuso, Livia L. Sa-Barreto, Marcilio Cunha-Filho. Compatibility and stability studies involving polymers used in fused deposition modeling 3D printing of medicines[J]. Journal of Pharmaceutical Analysis, 2022, 12(3): 424-435. doi: 10.1016/j.jpha.2021.09.010

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Compatibility and stability studies involving polymers used in fused deposition modeling 3D printing of medicines

doi: 10.1016/j.jpha.2021.09.010

a. Laboratory of Food, Drug, and Cosmetics (LTMAC), School of Health Sciences, University of Brasilia, 70910-900, Brasília, DF, Brazil;
b. Faculty of Ceilandia, University of Brasilia (UnB), 72220-900, Brasília, DF, Brazil

Funds:

This research was financially supported by the Brazilian agencies DPI/UnB, FAP-DF (Grant No.: 193.001.741/2017), and CNPq (Grant No.: 408291/2018–4). The authors would like to thank the contribution of Ms. Daniela Galter and Ms. Karina Riccomini from Ashland Specialty Ingredients, Ms. Beatriz Pancica from Merck, Ms. Renata Colenci from Evonik, and Mr. Fabio Ito from BASF for kindly supplying the material used in this work. Additionally, the authors thank the laboratory LaProNat/UnB for allowing the use of its facilities.

Received Date: May 23, 2021
Accepted Date: Sep. 17, 2021
Rev Recd Date: Sep. 03, 2021
Publish Date: Sep. 20, 2021

Abstract

Abstract

One of the challenges in developing three-dimensional printed medicines is related to their stability due to the manufacturing conditions involving high temperatures. This work proposed a new protocol for preformulation studies simulating thermal processing and aging of the printed medicines, tested regarding their morphology and thermal, crystallographic, and spectroscopic profiles. Generally, despite the strong drug-polymer interactions observed, the chemical stability of the model drugs was preserved under such conditions. In fact, in the metoprolol and Soluplus^® composition, the drug's solubilization in the polymer produced a delay in the drug decomposition, suggesting a protective effect of the matrix. Paracetamol and polyvinyl alcohol mixture, in turn, showed unmistakable signs of thermal instability and chemical decomposition, in addition to physical changes. In the presented context, establishing protocols that simulate processing and storage conditions may be decisive for obtaining stable pharmaceutical dosage forms using three-dimensional printing technology.
- Three-dimensional printing,
- Preformulation,
- Hot-melt extrusion,
- Thermal analysis,
- Drug-polymer compatibility

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References(50)

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