2016 Vol. 6, No. 6

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Screening primary racemic amines for enantioseparation by derivatized polysaccharide and cyclofructan columns☆
Yeeun Lim, Zachary S. Breitbach, Daniel W. Armstrong, Alain Berthod
2016, 6(6): 345-355.
Abstract(145) PDF(4)
Abstract:
It is a challenge to separate the enantiomers of native chiral amines prone to deleterious silanol interactions. A set of 39 underivatized chiral primary amines was screened for enantiomeric separation. Seven recently introduced commercial chiral columns were tested. They included six polysaccharide...
Comparison of ESI-and APCI-LC-MS/MS methods:A case study of levonorgestrel in human plasma☆
Rulin Wang, Lin Zhang, Zunjian Zhang, Yuan Tian
2016, 6(6): 356-362.
Abstract(112) PDF(5)
Abstract:
Electrospray ionization (ESI) and atmospheric pressure chemical ionization (APCI) techniques for liquid chromatography–tandem mass spectrometry (LC–MS/MS) determination of levonorgestrel were evaluated. In consideration of difference in ionization mechanism, the two ionization sources were compared ...
Structural characterization of monoterpene indole alkaloids in ethanolic extracts of Rauwolfia species by liquid chromatography with quadrupole time-of-flight mass spectrometry
Sunil Kumar, Awantika Singh, Vikas Bajpai, Mukesh Srivastava, Bhim Pratap Singh, Brijesh Kumar
2016, 6(6): 363-373.
Abstract(97) PDF(3)
Abstract:
Rauwolfia species (Apocynaceae) are medicinal plants well known worldwide due to its potent bioactive monoterpene indole alkaloids (MIAs) such as reserpine, ajmalicine, ajmaline, serpentine and yohimbine. Reserpine, ajmalicine and ajmaline are powerful antihypertensive, tranquilizing agents used in ...
The impact of storage conditions upon gentamicin coated antimicrobial implants☆
Nicholas D. Mullins, Benjamin J. Deadmana, Humphrey A. Moynihan, Florence O. McCarthy, Simon E. Lawrence, Jonathan Thompson, Anita R. Maguire
2016, 6(6): 374-381.
Abstract(108) PDF(3)
Abstract:
A systematic approach was developed to investigate the stability of gentamicin sulfate (GS) and GS/poly (lactic-co-glycolic acid) (PLGA) coatings on hydroxyapatite surfaces. The influence of environmental factors (light, humidity, oxidation and heat) upon degradation of the drug in the coatings was ...
Optimization of microwave-assisted extraction of bioactive alkaloids from lotus plumule using response surface methodology☆
Wei Xiong, Xianqiang Chen, Guangping Lv, Dejun Hu, Jing Zhao, Shaoping Li
2016, 6(6): 382-388.
Abstract(134) PDF(3)
Abstract:
In this work, a fast and efficient microwave-assisted extraction (MAE) method was developed to extract main bioactive alkaloids from lotus plumue. To optimize MAE conditions, three main factors were selected using univariate approach experiments, and then central composite design (CCD). The optimal ...
Wound healing activity of Delonix elata stem bark extract and its isolated constituent quercetin-3-rhamnopyranosyl-(1-6) glucopyranoside in rats☆
Pradeepa Krishnappa, Krishna Venkatarangaiah, Venkatesh, Santosh Kumar Shimoga Rajanna, Rebijith Kayattukandy Balan
2016, 6(6): 389-395.
Abstract(111) PDF(3)
Abstract:
Delonix elata L. is a Ceasalpinaceae species and is traditionally used in India for treatment of skin diseases, liver diseases and rheumatic problems. However, systematic evaluation of its wound healing activity is lacking. Thus, in the present study, we aimed to assess the wound healing activity of...
Development of an HPLC-UV assay method for the simultaneous quantification of nine antiretroviral agents in the plasma of HIV-infected patients
Nitin Charbe, Sara Baldelli, Valeria Cozzi, Simone Castoldi, Dario Cattaneo, Emilio Clementi
2016, 6(6): 396-403.
Abstract(86) PDF(2)
Abstract:
A new method using high-performance liquid chromatography coupled with ultra violet detection (HPLC–UV) was developed and validated for the simultaneous quantification of atazanavir, dolutegravir, darunavir, efavirenz, etravirine lopinavir, raltegravir, rilpivirine and tipranavir in human plasma. Fo...
Determination of pKa values of alendronate sodium in aqueous solution by piecewise linear regression based on acid-base potentiometric titration
Jing Ke, Hanfei Dou, Ximin Zhang, Dushimabararezi Serge Uhagaze, Xiali Ding, Yuming Dong
2016, 6(6): 404-409.
Abstract(100) PDF(3)
Abstract:
As a mono-sodium salt form of alendronic acid, alendronate sodium presents multi-level ionization for the dissociation of its four hydroxyl groups. The dissociation constants of alendronate sodium were determined in this work by studying the piecewise linear relationship between volume of titrant an...
CdS nanocrystals as fluorescent probe for detection of dolasetron mesylate in aqueous solution:Application to biomedical analysis
Samadhan P. Pawar, Laxman S. Walekar, Uttam R. Kondekar, Dattatray B. Gunjal, Anil H. Gore, Prashant V. Anbhule, Shivajirao R. Patil, Govind B. Kolekar
2016, 6(6): 410-416.
Abstract(87) PDF(2)
Abstract:
A simple and straightforward method for the determination of dolasetron mesylate (DM) in aqueous solution was developed based on the fluorescence quenching of 3-Mercaptopropionic acid (MPA) capped CdS quantum dots (QDs). The structure, morphology, and optical properties of synthesized QDs were chara...
Journal of Pharmaceutical Analysis
2016, 6(6): 417-418.
Abstract(124) PDF(2)
Abstract:

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