2016 Vol. 6, No. 5

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Development of a physiologically relevant dripping analytical method using simulated nasal mucus for nasal spray formulation analysis$
Tina Masiuk n, Parul Kadakia, Zhenyu Wang
2016, 5(5): 283-291.
Abstract(85) PDF(5)
Abstract:
Current methods for nasal spray formulations have been elementary evaluating the dripping char-acteristics of a formulation and have not assessed the behavior of the nasal formulation in the presence of varying types of mucus depending on the indication or diseased state. This research investigated ...
Detection of phthalates migration from disposable tablewares to drinking water using hexafluoroisopropanol-induced catanionic surfactant coacervate extraction$
Cao Li, Jia Xu, Dan Chen, Yuxiu Xiao
2016, 5(5): 292-299.
Abstract(91) PDF(1)
Abstract:
Hexafluoroisopropanol (HFIP)-induced sodium dodecyl sulfate/dodecyltrimethylammonium bromide (SDS/DTAB) catanionic surfactant coacervate extraction method coupled with high performance liquid chromatography (HPLC) was used to detect the migration of phthalates from disposable tablewares to drinking ...
Inclusion complexes of cefuroxime axetil withβ-cyclodextrin:Physicochemical characterization, molecular modeling and effect of L-arginine on complexation$
Sarika Sapte, Yogesh Pore
2016, 5(5): 300-306.
Abstract(73) PDF(1)
Abstract:
The inclusion complexes of poorly water-soluble cephalosporin, cefuroxime axetil (CFA), were prepared withβ-cyclodextrin (βCD) with or without addition of L-arginine (ARG) to improve its physicochemical properties. We also investigated the effect of ARG on complexation efficiency (CE) ofβCD towards ...
Analysis of residual crosslinking agent content in UV cross-linked poly(ethylene oxide) hydrogels for dermatological application by gas chromatography$
Rachel Shet Hui Wong, Mark Ashton, Kalliopi Dodou n
2016, 5(5): 307-312.
Abstract(139) PDF(1)
Abstract:
Acrylates have been widely used in the synthesis of pharmaceutical polymers. The quantitation of re-sidual acrylate monomers is vital as they are strong irritants and allergens, but after polymerization, are relatively inert, causing no irritation and allergies. Poly(ethylene oxide) (PEO) hydrogels ...
Pharmacokinetics of gene recombined angiogenesis inhibitor Kringle 5 in vivo using 131I specific markers and SPECT/CT$
Ge Yan, Danrong Yang, Yan Yu, Jianjun Xue, Yifan Jia, Xuanzi Sun, Boyu Wang, Zewei Zhao, Maode Wang
2016, 5(5): 313-317.
Abstract(74) PDF(1)
Abstract:
The previous pharmacokinetic methods can be only limited to drug analysis in vitro, which provide less information on the distribution and metabolismof drugs, and limit the interpretation and assessment of pharmacokinetics, the determination of metabolic principles, and evaluation of treatment effec...
Isocoreopsin:An active constituent of n-butanol extract of Butea monosperma flowers against colorectal cancer (CRC)$
Boopathi Subramaniyan, Navaneethakrishnan Polachi, Ganeshan Mathan n
2016, 5(5): 318-325.
Abstract(147) PDF(1)
Abstract:
The herb Butea monosperma constitutes several human health beneficial components, which are mostly studied for their anticancer effects. In this study, the activity of n-butanol fractions of B. monosperma floral extract was examined on inhibiting aberrant crypt foci (ACF) formation in azoxymethane i...
A simple dilute and shoot methodology for the identification and quantification of illegal insulin$
Celine Vanhee n, Steven Janvier, Goedele Moens, Eric Deconinck, Patricia Courselle
2016, 5(5): 326-334.
Abstract(225) PDF(2)
Abstract:
The occurrence of illegal medicines is a well-established global problem and concerns mostly small molecules. However, due to the advances in genomics and recombinant expression technologies there is an increased development of polypeptide therapeutics. Insulin is one of the best known polypeptide d...
Quantification of neomangiferin in rat plasma by liquid chromatography-tandem mass spectrometry and its application to bioavailability study$
Bo Yang, Zhirui Liu, Shenglan Shang, Xiaojian Qin, Peiyuan Xia
2016, 5(5): 335-340.
Abstract(77) PDF(0)
Abstract:
Neomangiferin, a natural C-glucosyl xanthone, has recently received a great deal of attention due to its multiple biological activities. In this study, a rapid and sensitive ultra-high performance liquid chroma-tography tandem mass spectrometry (UHPLC–MS/MS) method for the quantification of neomangi...
Development and characterization of ethylcellulose based microsphere for sustained release of nifedipine$
Patitapabana Parida, Subash Chandra Mishra, Subhashree Sahoo, Ajit Behera, Bibhukalyan Prasad Nayak
2016, 5(5): 341-344.
Abstract(161) PDF(0)
Abstract:
This article introduced the work of ethylcellulose based polymeric microsphere loaded with nifedipine for reduction in frequency of administration with low solubility in aqueous medium and high rate of absorption in the stomach. The non-aqueous polymeric suspension was put dropwise into an aqueous m...
Journal of Pharmaceutical Analysis
2016, 5(5): 345-346.
Abstract(99) PDF(0)
Abstract:

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