Green analytical chemistry metrics for evaluating the greenness of analytical procedures

Lei Yin; Luyao Yu; Yingxia Guo; Chuya Wang; Yuncheng Ge; Xinyue Zheng; Ning Zhang; Jiansong You; Yong Zhang; Meiyun Shi

doi:10.1016/j.jpha.2024.101013

Volume 14 Issue 11

Nov. 2024

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Article Navigation > Journal of Pharmaceutical Analysis > 2024 > 14(11): 101013

Lei Yin, Luyao Yu, Yingxia Guo, Chuya Wang, Yuncheng Ge, Xinyue Zheng, Ning Zhang, Jiansong You, Yong Zhang, Meiyun Shi. Green analytical chemistry metrics for evaluating the greenness of analytical procedures[J]. Journal of Pharmaceutical Analysis, 2024, 14(11): 101013. doi: 10.1016/j.jpha.2024.101013

Citation:

Lei Yin, Luyao Yu, Yingxia Guo, Chuya Wang, Yuncheng Ge, Xinyue Zheng, Ning Zhang, Jiansong You, Yong Zhang, Meiyun Shi. Green analytical chemistry metrics for evaluating the greenness of analytical procedures[J]. Journal of Pharmaceutical Analysis, 2024, 14(11): 101013. doi: 10.1016/j.jpha.2024.101013

Citation:

Lei Yin, Luyao Yu, Yingxia Guo, Chuya Wang, Yuncheng Ge, Xinyue Zheng, Ning Zhang, Jiansong You, Yong Zhang, Meiyun Shi. Green analytical chemistry metrics for evaluating the greenness of analytical procedures[J]. Journal of Pharmaceutical Analysis, 2024, 14(11): 101013. doi: 10.1016/j.jpha.2024.101013

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Green analytical chemistry metrics for evaluating the greenness of analytical procedures

doi: 10.1016/j.jpha.2024.101013

a. Cancer Hospital of Dalian University of Technology, Dalian University of Technology, Shenyang, 110042, China;
b. School of Chemical Engineering, Ocean and Life Sciences, Dalian University of Technology, Panjin, Liaoning, 124221, China;
c. Aim Honesty Biopharmaceutical Co., Ltd., Dalian, Liaoning, 116600, China

Funds:

This work was financially supported by the National Natural Science Foundation of China (Grant Nos.: 81603182 and 81703607), the Fundamental Research Funds for the Central Universities, China (Grant Nos.: DUT24MS018, DUT23YG228, DUT21RC(3)057), the Open funding of Cancer Hospital of Dalian University of Technology, China (Grant No.: 2024-ZLKF-33), and the Natural Science Foundation of Liaoning Province, China (Grant No.: 2023-MSBA-018).

Received Date: Nov. 18, 2023
Accepted Date: May 23, 2024
Rev Recd Date: May 21, 2024
Publish Date: May 25, 2024

Abstract

Abstract

Green analytical chemistry (GAC) focuses on mitigating the adverse effects of analytical activities on human safety, human health, and environment. In addition to the 12 principles of GAC, proper GAC tools should be developed and employed to assess the greenness of different analytical assays. The 15 widely used GAC metrics, i.e., national environmental methods index (NEMI), advanced NEMI, assessment of green profile (AGP), chloroform-oriented toxicity estimation scale (ChlorTox Scale), Analytical Eco-Scale, Green Certificate Modified Eco-Scale, analytical method greenness score (AMGS), green analytical procedure index (GAPI), ComplexGAPI, red-green-blue (RGB) additive color model, RGB 12 algorithm, analytical greenness calculator (AGREE), AGREE preparation (AGREEprep), HEXAGON, and blue applicability grade index (BAGI), are selected as the typical tools. This article comprehensively presents and elucidates the principles, characteristics, merits, and demerits of 15 widely used GAC tools. This review is helpful for researchers to use the current GAC metrics to assess the environmental sustainability of analytical assays.
- Greenness metric,
- Green analytical chemistry,
- Analytical methods,
- Environmental sustainability

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References(106)

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