Automated closed-cell production platform solves dilemma of industrial-scale manufacturing for mesenchymal stromal cell-based therapy

Yirui Feng; Bin Wang

doi:10.1016/j.jpha.2023.08.017

Volume 13 Issue 11

Nov. 2023

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Yirui Feng, Bin Wang. Automated closed-cell production platform solves dilemma of industrial-scale manufacturing for mesenchymal stromal cell-based therapy[J]. Journal of Pharmaceutical Analysis, 2023, 13(11): 1233-1234. doi: 10.1016/j.jpha.2023.08.017

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Yirui Feng, Bin Wang. Automated closed-cell production platform solves dilemma of industrial-scale manufacturing for mesenchymal stromal cell-based therapy[J]. Journal of Pharmaceutical Analysis, 2023, 13(11): 1233-1234. doi: 10.1016/j.jpha.2023.08.017

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Automated closed-cell production platform solves dilemma of industrial-scale manufacturing for mesenchymal stromal cell-based therapy

doi: 10.1016/j.jpha.2023.08.017

Yirui Feng^a,b,
Bin Wang^{a
,
,}

a. Clinical Stem Cell Center, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, 210000, China;
b. School of Life Science, Nanjing University, Nanjing, 210000, China

Received Date: Jun. 03, 2023
Accepted Date: Aug. 27, 2023
Rev Recd Date: Aug. 24, 2023
Publish Date: Oct. 31, 2023

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References

H. Tavassoli, S.N. Alhosseini, A. Tay, et al., Large-scale production of stem cells utilizing microcarriers: A biomaterials engineering perspective from academic research to commercialized products, Biomaterials 181 (2018) 333-346.

A.L. van Wezel, Growth of cell-strains and primary cells on micro-carriers in homogeneous culture, Nature 216 (1967) 64-65.

K. Song, Y. Yang, S. Wu, et al., In vitro culture and harvest of BMMSCs on the surface of a novel thermosensitive glass microcarrier, Mater. Sci. Eng. C Mater. Biol. Appl. 58 (2016) 324-330.

A.D. Dias, J.M. Elicson, W.L. Murphy, Microcarriers with synthetic hydrogel surfaces for stem cell expansion, Adv. Healthc. Mater. 6 (2017), 1700072.

B. Koh, N. Sulaiman, M.B. Fauzi, et al., Three dimensional microcarrier system in mesenchymal stem cell culture: A systematic review, Cell Biosci. 10 (2020), 75.

D. Schop, R. van Dijkhuizen-Radersma, E. Borgart, et al., Expansion of human mesenchymal stromal cells on microcarriers: Growth and metabolism, J. Tissue Eng. Regen. Med. 4 (2010) 131-140.

Y.M. Lin, J. Lee, J.F.Y. Lim, et al., Critical attributes of human early mesenchymal stromal cell-laden microcarrier constructs for improved chondrogenic differentiation, Stem Cell Res. Ther. 8 (2017), 93.

Y. Zhang, T. Na, K. Zhang, et al., GMP-grade microcarrier and automated closed industrial scale cell production platform for culture of MSCs, J. Tissue Eng. Regen. Med. 16 (2022) 934-944.

X. Yan, K. Zhang, Y. Yang, et al., Dispersible and dissolvable porous microcarrier tablets enable efficient large-scale human mesenchymal stem cell expansion, Tissue Eng. Part C Methods 26 (2020) 263-275.

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