Abstract: Colorectal cancer (CRC) is among the leading causes of cancer mortality. The lifetime risk of developing CRC is about 5% in adult males and females. CRC is usually diagnosed at an advanced stage, and at this point therapy has a limited impact on cure rates and long-term survival. Novel and/or improv...
Abstract: Waterborne viruses that can be harmful to human health pose significant challenges globally, affecting health care systems and the economy. Identifying these waterborne pathogens is essential for preventing diseases and protecting public health. However, handling complex samples such as human and wa...
Abstract: Traditional Chinese medicine (TCM) is a treasure of the Chinese nation, providing effective solutions to current medical requisites. Various spectral techniques are undergoing continuous development and provide new and reliable means for evaluating the efficacy and quality of TCM. Because spectral t...
Abstract: Hepatosteatosis is characterized by abnormal accumulation of triglycerides (TG), leading to prolonged and chronic inflammatory infiltration. To date, there is still a lack of effective and economical therapies for hepatosteatosis. Oridonin (ORI) is a major bioactive component extracted from the trad...
Abstract: Ginsenoside Rg5 is a rare ginsenoside showing promising tumor-suppressive effects. This study aimed to explore its radio-sensitizing effects and the underlying mechanisms. Human lung adenocarcinoma cell lines A549 and Calu-3 were used for in vitro and in vivo analysis. Bioinformatic molecular dockin...
Abstract: The canonical transient receptor potential channel (TRPC) proteins form Ca2+-permeable cation channels that are involved in various heart diseases. However, the roles of specific TRPC proteins in myocardial ischemia/reperfusion (I/R) injury remain poorly understood. We observed that TRPC1 and TRPC6 ...
Abstract: Diabetic retinopathy (DR) is a prevalent microvascular complication of diabetes and the leading cause of blindness and severe visual impairment in adults. The high levels of glucose trigger multiple intracellular oxidative stress pathways, such as POLDIP2, resulting in excessive reactive oxygen spec...
Abstract: This study proposes a hypodermic needle (HN) as a sorbent holder and an electrospray (ESI) emitter, thus combining extraction and analysis in a single device. A novel nylon 6-cellulose (N6-Cel) composite sorbent is proposed to extract methadone from oral fluid samples. The cellulosic substrate provi...
Abstract: Amino-containing compounds, including amino acids, aliphatic amines, aromatic amines, small peptides and catecholamines, are involved in various biological processes and play vital roles in multiple metabolic pathways. Previous studies indicated that some amino-containing metabolites are significant...
Abstract: In this work, a new pyrylium derivatization-assisted liquid chromatography-mass spectrometry (LC-MS) method was developed for metabolite profiling of the glutathione anabolic pathway (GAP) in cancer tissues and cells. The pyrylium salt of 6,7-dimethoxy-3-methyl isochromenylium tetrafluoroborate (DMM...
00147-8207376d7-5b9e-439a-a2ec-3446b4fe18b1.jpg)
00209-51da8f2de-30b3-439c-913f-b7fc8bc4697d.jpg)
00146-63e91f07d-b3e6-4075-8f8e-114d92b37000.jpg)
00201-07ef283b9-959d-419b-b057-dd481b1ce442.jpg)
00116-8c8bf1ccb-b586-4f3b-9bd3-3815e3779e80.jpg)
00212-55d6f390c-54e4-458b-801e-bb42087e6c4d.jpg)
00090-4bffb2645-4b32-47a1-902c-0fe0b8a680b4.jpg)
00127-2281aa766-3b00-4f3d-bab1-ce83db414a31.jpg)
00120-Xae7f1a43-fdf8-4cd9-8f1b-868c64528b8a.jpg)
00207-1c97fb615-dfc8-4f95-8ea1-21a02bb37d99.jpg)
