Volume 13 Issue 9
Sep.  2023
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Article Navigation >  Journal of Pharmaceutical Analysis  > 2023  >  13(9): 968-983
Wentao Li, Chongyu Shao, Chang Li, Huifen Zhou, Li Yu, Jiehong Yang, Haitong Wan, Yu He. Metabolomics: A useful tool for ischemic stroke research[J]. Journal of Pharmaceutical Analysis, 2023, 13(9): 968-983. doi: 10.1016/j.jpha.2023.05.015
Citation: Wentao Li, Chongyu Shao, Chang Li, Huifen Zhou, Li Yu, Jiehong Yang, Haitong Wan, Yu He. Metabolomics: A useful tool for ischemic stroke research[J]. Journal of Pharmaceutical Analysis, 2023, 13(9): 968-983. doi: 10.1016/j.jpha.2023.05.015
shu

Metabolomics: A useful tool for ischemic stroke research

doi: 10.1016/j.jpha.2023.05.015

  • a. School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou, 310053, China;

  • b. School of Basic Medicine Sciences, Zhejiang Chinese Medical University, Hangzhou, 310053, China

Funds:

This work was supported by the National Natural Science Foundation of China (Grant Nos.: 81873226, and 81874366), and the Zhejiang Provincial Science and Technology Innovation Leading Talent Project of “Ten Thousand Talents Plan” (2019).

  • Received Date: Feb. 17, 2023
  • Accepted Date: May 29, 2023
  • Rev Recd Date: May 14, 2023
  • Publish Date: Jun. 03, 2023
    Abstract
  • Ischemic stroke (IS) is a multifactorial and heterogeneous disease. Despite years of studies, effective strategies for the diagnosis, management and treatment of stroke are still lacking in clinical practice. Metabolomics is a growing field in systems biology. It is starting to show promise in the identification of biomarkers and in the use of pharmacometabolomics to help patients with certain disorders choose their course of treatment. The development of metabolomics has enabled further and more biological applications. Particularly, metabolomics is increasingly being used to diagnose diseases, discover new drug targets, elucidate mechanisms, and monitor therapeutic outcomes and its potential effect on precision medicine. In this review, we reviewed some recent advances in the study of metabolomics as well as how metabolomics might be used to identify novel biomarkers and understand the mechanisms of IS. Then, the use of metabolomics approaches to investigate the molecular processes and active ingredients of Chinese herbal formulations with anti-IS capabilities is summarized. We finally summarized recent developments in single cell metabolomics for exploring the metabolic profiles of single cells. Although the field is relatively young, the development of single cell metabolomics promises to provide a powerful tool for unraveling the pathogenesis of IS.
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