Journal of Pharmaceutical Analysis

CLDN18.2-targeted molecular imaging and precision therapy of gastrointestinal tumors

Yan Chen, Zhi Yang, Xueyun Gao, Hua Zhu

2023, 13(9): 955-957. doi: 10.1016/j.jpha.2023.08.007

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Comment on: “Development of a CLDN18.2-targeting immuno-PET probe for non-invasive imaging in gastrointestinal tumors”

Cuicui Li, Xiaoyuan Chen, Jingjing Zhang

2023, 13(9): 958-959. doi: 10.1016/j.jpha.2023.07.010

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Applications and safety of gold nanoparticles as therapeutic devices in clinical trials

Leeann Yao, Dejan Bojic, Mingyao Liu

2023, 13(9): 960-967. doi: 10.1016/j.jpha.2023.06.001

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Use of gold nanoparticles (GNPs) in medicine is an emerging field of translational research with vast clinical implications and exciting therapeutic potential. However, the safety of using GNPs in human subjects is an important question that remains unanswered. This study reviews over 20 clinical tr...

Metabolomics: A useful tool for ischemic stroke research

Wentao Li, Chongyu Shao, Chang Li, Huifen Zhou, Li Yu, Jiehong Yang, Haitong Wan, Yu He

2023, 13(9): 968-983. doi: 10.1016/j.jpha.2023.05.015

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Ischemic stroke (IS) is a multifactorial and heterogeneous disease. Despite years of studies, effective strategies for the diagnosis, management and treatment of stroke are still lacking in clinical practice. Metabolomics is a growing field in systems biology. It is starting to show promise in the i...

1,8-cineole ameliorates colon injury by downregulating macrophage M1 polarization via inhibiting the HSP90-NLRP3-SGT1 complex

Shengsuo Ma, Bing Yang, Yang Du, Yiwen Lv, Jiarong Liu, Yucong Shi, Ting Huang, Huachong Xu, Li Deng, Xiaoyin Chen

2023, 13(9): 984-998. doi: 10.1016/j.jpha.2023.07.001

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Ulcerative colitis (UC) is characterized by chronic relapsing intestinal inflammation. Currently, there is no effective treatment for the disease. According to our preliminary data, 1,8-cineole, which is the main active compound of Amomum compactum Sol. ex Maton volatile oil and an effective drug fo...

Ginsenoside Rk2, a dehydroprotopanaxadiol saponin, alleviates alcoholic liver disease via regulating NLRP3 and NLRP6 inflammasome signaling pathways in mice

Jian Zou, Rujie Yang, Ruibing Feng, Jiayue Liu, Jian-Bo Wan

2023, 13(9): 999-1012. doi: 10.1016/j.jpha.2023.05.005

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Heavy alcohol consumption results in alcoholic liver disease (ALD) with inadequate therapeutic options. Here, we first report the potential beneficial effects of ginsenoside Rk2 (Rk2), a rare dehydroprotopanaxadiol saponin isolated from streamed ginseng, against alcoholic liver injury in mice. Chron...

Quantification of soluble epoxide hydrolase inhibitors in experimental and clinical samples using the nanobody-based ELISA

Huiyi Yang, Meng Qi, Qiyi He, Sung Hee Hwang, Jun Yang, Mark McCoy, Christophe Morisseau, Suqing Zhao, Bruce D. Hammock

2023, 13(9): 1013-1023. doi: 10.1016/j.jpha.2023.05.006

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To ensure proper dosage of a drug, analytical quantification of it in biofluid is necessary. Liquid chromatography mass spectrometry (LC-MS) is the conventional method of choice as it permits accurate identification and quantification. However, it requires expensive instrumentation and is not approp...

Gut microbiota-based pharmacokinetic-pharmacodynamic study and molecular mechanism of specnuezhenide in the treatment of colorectal cancer targeting carboxylesterase

Hang Yu, Hui Xu, Xinyu Yang, Zhengwei Zhang, Jiachun Hu, Jinyue Lu, Jie Fu, Mengmeng Bu, Haojian Zhang, Zhao Zhai, Jingyue Wang, Jiandong Jiang, Yan Wang

2023, 13(9): 1024-1040. doi: 10.1016/j.jpha.2023.06.012

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Specnuezhenide (SNZ) is among the main components of Fructus Ligustri Lucidi, which has anti-inflammation, anti-oxidation, and anti-tumor effect. The low bioavailability makes it difficult to explain the mechanism of pharmacological effect of SNZ. In this study, the role of the gut microbiota in the...

Rapid metabolic fingerprinting with the aid of chemometric models to identify authenticity of natural medicines: Turmeric, Ocimum, and Withania somnifera study

Samreen Khan, Abhishek Kumar Rai, Anjali Singh, Saudan Singh, Basant Kumar Dubey, Raj Kishori Lal, Arvind Singh Negi, Nicholas Birse, Prabodh Kumar Trivedi, Christopher T. Elliott, Ratnasekhar Ch

2023, 13(9): 1041-1057. doi: 10.1016/j.jpha.2023.04.018

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Herbal medicines are popular natural medicines that have been used for decades. The use of alternative medicines continues to expand rapidly across the world. The World Health Organization suggests that quality assessment of natural medicines is essential for any therapeutic or health care applicati...

Eight Zhes Decoction ameliorates the lipid dysfunction of nonalcoholic fatty liver disease using integrated lipidomics, network pharmacology and pharmacokinetics

Yuping Zhou, Ze Dai, Kaili Deng, Yubin Wang, Jiamin Ying, Donghui Chu, Jinyue Zhou, Chunlan Tang

2023, 13(9): 1058-1069. doi: 10.1016/j.jpha.2023.05.012

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Nonalcoholic fatty liver disease (NAFLD) has developed into the most common chronic liver disease and can lead to liver cancer. Our laboratory previously developed a novel prescription for NAFLD, “Eight Zhes Decoction” (EZD), which has shown good curative effects in clinical practice. However, the p...

Characterization of natural peptides in Pheretima by integrating proteogenomics and label-free peptidomics

Xiaoxiao Luo, Qirui Bi, Dongdong Huang, Yun Li, Changliang Yao, Jianqing Zhang, Wenlong Wei, Jiayuan Li, Zhenwei Li, Jingxian Zhang, Shen Ji, Yurong Wang, De-an Guo

2023, 13(9): 1070-1079. doi: 10.1016/j.jpha.2023.06.006

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Pheretima, also called “earthworms”, is a well-known animal-derived traditional Chinese medicine that is extensively used in over 50 Chinese patent medicines (CPMs) in Chinese Pharmacopoeia (2020 edition). However, its zoological origin is unclear, both in the herbal market and CPMs. In this study, ...

Targeted bile acids metabolomics in cholesterol gallbladder polyps and gallstones: From analytical method development towards application to clinical samples

Jiaojiao Wei, Tao Chen, Yamin Liu, Shuai Sun, Zhiqing Yuan, Yixin Zhang, Aizhen Xiong, Linnan Li, Zhengtao Wang, Li Yang

2023, 13(9): 1080-1087. doi: 10.1016/j.jpha.2023.06.003

Abstract(798) HTML Full Text PDF(48) [Cited by] (12)

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Bile acids (BAs) are synthesized by the liver from cholesterol through several complementary pathways and aberrant cholesterol metabolism plays pivotal roles in the pathogeneses of cholesterol gallbladder polyps (CGP) and cholesterol gallstones (CGS). To date, there is neither systematic study on BA...

2023 Vol. 13, No. 9