Bi<sub>2</sub>O<sub>3</sub>/ZnO nanocomposite: Synthesis, characterizations and its application in electrochemical detection of balofloxacin as an anti-biotic drug

Sana Ansari; M. Shahnawaze Ansari; Soami P. Satsangee; Rajeev Jain

doi:10.1016/j.jpha.2020.03.013

Volume 11 Issue 1

Feb. 2021

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Sana Ansari, M. Shahnawaze Ansari, Soami P. Satsangee, Rajeev Jain. Bi2O3/ZnO nanocomposite: Synthesis, characterizations and its application in electrochemical detection of balofloxacin as an anti-biotic drug[J]. Journal of Pharmaceutical Analysis, 2021, 11(1): 57-67. doi: 10.1016/j.jpha.2020.03.013

Citation:

Sana Ansari, M. Shahnawaze Ansari, Soami P. Satsangee, Rajeev Jain. Bi₂O₃/ZnO nanocomposite: Synthesis, characterizations and its application in electrochemical detection of balofloxacin as an anti-biotic drug[J]. Journal of Pharmaceutical Analysis, 2021, 11(1): 57-67. doi: 10.1016/j.jpha.2020.03.013

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Bi₂O₃/ZnO nanocomposite: Synthesis, characterizations and its application in electrochemical detection of balofloxacin as an anti-biotic drug

doi: 10.1016/j.jpha.2020.03.013

a. Department of Chemistry, Dayalbagh Educational Institute, Dayalbagh, Agra, 282005, India;
b. Center of Nanotechnology, King Abdulaziz University, Jeddah, 21589, Saudi Arabia;
c. Advanced Membrane Technology Research Centre (AMTEC), Universiti Teknologi Malaysia, 81310, Skudai, Johor, Malaysia;
d. School of Chemical and Energy Engineering, Universiti Teknologi Malaysia, 81310, Skudai, Johor, Malaysia;
e. School of Studies in Chemistry, Jiwaji University, Gwalior, 474011, India

Funds:

The authors express their gratitude to the University Grants Commission (UGC) for providing Maulana Azad National Fellowship for minority students.

Received Date: Nov. 11, 2019
Accepted Date: Mar. 30, 2020
Rev Recd Date: Mar. 27, 2020
Available Online: Jan. 24, 2022
Publish Date: Feb. 15, 2021

Abstract

Abstract

In the present work, a chemically modified electrode has been fabricated utilizing Bi₂O₃/ZnO nanocomposite. The nanocomposite was synthesized by simple sonochemical method and characterized for its structural and morphological properties by using XRD, FESEM, EDAX, HRTEM and XPS techniques. The results clearly indicated co-existence of Bi₂O₃ and ZnO in the nanocomposite with chemical interaction between them. Bi₂O₃/ZnO nanocomposite based glassy carbon electrode (GCE) was utilized for sensitive voltammetric detection of an anti-biotic drug (balofloxacin). The modification amplified the electroactive surface area of the sensor, thus providing more sites for oxidation of analyte. Cyclic and square wave voltammograms revealed that Bi₂O₃/ZnO modified electrode provides excellent electrocatalytic action towards balofloxacin oxidation. The current exhibited a wide linear response in concentration range of 150–1000 nM and detection limit of 40.5 nM was attained. The modified electrode offered advantages in terms of simplicity of preparation, fair stability (RSD 1.45%), appreciable reproducibility (RSD 2.03%) and selectivity. The proposed sensor was applied for determining balofloxacin in commercial pharmaceutical formulations and blood serum samples with the mean recoveries of 99.09% and 99.5%, respectively.
- ZnO nanoparticles,
- Chemically modified electrode,
- Voltammetry,
- Drug analysis

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References(58)

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