2021 Vol. 11, No. 1

Review paper
Towards wearable and implantable continuous drug monitoring: A review
Sumin Bian, Bowen Zhu, Guoguang Rong, Mohamad Sawan
2021, 11(1): 1-14. doi: 10.1016/j.jpha.2020.08.001
Abstract:
Continuous drug monitoring is a promising alternative to current therapeutic drug monitoring strategies and has a strong potential to reshape our understanding of pharmacokinetic variability and to improve individualised therapy. This review highlights recent advances in biosensing technologies that...
Analytical methodologies for sensing catechol-O-methyltransferase activity and their applications
Fang-Yuan Wang, Ping Wang, Dong-Fang Zhao, Frank J. Gonzalez, Yu-Fan Fan, Yang-Liu Xia, Guang-Bo Ge, Ling Yang
2021, 11(1): 15-27. doi: 10.1016/j.jpha.2020.03.012
Abstract:
Mammalian catechol-O-methyltransferases (COMT) are an important class of conjugative enzymes, which play a key role in the metabolism and inactivation of catechol neurotransmitters, catechol estrogens and a wide range of endobiotics and xenobiotics that bear the catechol group. Currently, COMT inhib...
Applications and challenges of low temperature plasma in pharmaceutical field
Lingge Gao, Xingmin Shi, Xili Wu
2021, 11(1): 28-36. doi: 10.1016/j.jpha.2020.05.001
Abstract:
Low temperature plasma (LTP) technology has shown an outstanding application value in the pharmaceutical filed in recent ten years. This paper reviews the research advances in LTP, including its effects on enhancing or inhibiting drug activity, its combined use with drugs to treat cancers, its effec...
Original article
Solid phase microextraction chemical biopsy tool for monitoring of doxorubicin residue during in vivo lung chemo-perfusion
Barbara Bojko, Nikita Looby, Mariola Olkowicz, Anna Roszkowska, Bogumiła Kupcewicz, Pedro Reck dos Santos, Khaled Ramadan, Shaf Keshavjee, Thomas K. Waddell, German Gómez-Ríos, Marcos Tascon, Krzysztof Goryński, Marcelo Cypel, Janusz Pawliszyn
2021, 11(1): 37-47. doi: 10.1016/j.jpha.2020.08.011
Abstract:
Development of a novel invivo lung perfusion (IVLP) procedure allows localized delivery of high-dose doxorubicin (DOX) for targeting residual micrometastatic disease in the lungs. However, DOX delivery via IVLP requires careful monitoring of drug level to ensure tissue concentrations of this agent r...
Synthesis and electrochemical properties of environmental free l-glutathione grafted graphene oxide/ZnO nanocomposite for highly selective piroxicam sensing
N. Dhanalakshmi, T. Priya, S. Thennarasu, S. Sivanesan, N. Thinakaran
2021, 11(1): 48-56. doi: 10.1016/j.jpha.2020.02.001
Abstract:
A simple and reliable strategy was proposed to engineer the glutathione grafted graphene oxide/ZnO nanocomposite (glutathione-GO/ZnO) as electrode material for the high-performance piroxicam sensor. The prepared glutathione-GO/ZnO nanocomposite was well characterized by X-ray diffraction (XRD), Four...
Bi2O3/ZnO nanocomposite: Synthesis, characterizations and its application in electrochemical detection of balofloxacin as an anti-biotic drug
Sana Ansari, M. Shahnawaze Ansari, Soami P. Satsangee, Rajeev Jain
2021, 11(1): 57-67. doi: 10.1016/j.jpha.2020.03.013
Abstract:
In the present work, a chemically modified electrode has been fabricated utilizing Bi2O3/ZnO nanocomposite. The nanocomposite was synthesized by simple sonochemical method and characterized for its structural and morphological properties by using XRD, FESEM, EDAX, HRTEM and XPS techniques. The resul...
Development of an analytical method for multi-residue quantification of 18 anthelmintics in various animal-based food products using liquid chromatography-tandem mass spectrometry
Kyung-Hee Yoo, Da-Hee Park, A.M. Abd El-Aty, Seong-Kwan Kim, Hae-Ni Jung, Da-Hye Jeong, Hee-Jung Cho, Ahmet Hacimüftüoğlu, Jae-Han Shim, Ji Hoon Jeong, Ho-Chul Shin
2021, 11(1): 68-76. doi: 10.1016/j.jpha.2020.03.008
Abstract:
In this study, we developed a simple screening procedure for the determination of 18 anthelmintics (including benzimidazoles, macrocyclic lactones, salicylanilides, substituted phenols, tetrahydropyrimidines, and imidazothiazoles) in five animal-derived food matrices (chicken muscle, pork, beef, mil...
Study of intracellular anabolism of 5-fluorouracil and incorporation in nucleic acids based on an LC-HRMS method
Christelle Machon, Frédéric Catez, Nicole Dalla Venezia, Floriane Vanhalle, Laetitia Guyot, Anne Vincent, Maxime Garcia, Béatrice Roy, Jean-Jacques Diaz, Jérôme Guitton
2021, 11(1): 77-87. doi: 10.1016/j.jpha.2020.04.001
Abstract:
5-Fluorouracil (5-FU) is an anticancer drug extensively used for different cancers. Intracellular metabolic activation leads to several nucleoside and nucleotide metabolites essential to exert its cytotoxic activity on multiple cellular targets such as enzymes, DNA and RNA. In this paper, we describ...
An ultra-robust fingerprinting method for quality assessment of traditional Chinese medicine using multiple reaction monitoring mass spectrometry
Zhenhao Li, Xiaohui Zhang, Jie Liao, Xiaohui Fan, Yiyu Cheng
2021, 11(1): 88-95. doi: 10.1016/j.jpha.2020.01.003
Abstract:
Chromatographic fingerprinting has been perceived as an essential tool for assessing quality and chemical equivalence of traditional Chinese medicine. However, this pattern-oriented approach still has some weak points in terms of chemical coverage and robustness. In this work, we proposed a multiple...
Comprehensive metabolic profiling of Alismatis Rhizoma triterpenes in rats based on characteristic ions and a triterpene database
Lu Wang, Sen Li, Jiaxin Li, Zhongzhe Cheng, Yulin Feng, Hui Ouyang, Zhifeng Du, Hongliang Jiang
2021, 11(1): 96-107. doi: 10.1016/j.jpha.2020.03.010
Abstract:
Alismatis Rhizoma (AR) is widely used in Chinese medicine, and its major bioactive components, triterpenes, reportedly possess various pharmacological activities. Therefore, it is very important to study the metabolism of triterpenes invivo. However, the metabolism of AR triterpene extract has not b...
Evaluation of apoptotic effects of mPEG-b-PLGA coated iron oxide nanoparticles as a eupatorin carrier on DU-145 and LNCaP human prostate cancer cell lines
Marziyeh Shalchi Tousi, Houri Sepehri, Sepideh Khoee, Mahdi Moridi Farimani, Ladan Delphi, Fariba Mansourizadeh
2021, 11(1): 108-121. doi: 10.1016/j.jpha.2020.04.002
Abstract:
Many studies have so far confirmed the efficiency of phytochemicals in the treatment of prostate cancer. Eupatorin, a flavonoid with a wide range of phytomedical activities, suppresses proliferation of and induces apoptosis of multiple cancer cell lines. However, low solubility, poor bioavailability...
Short communication
Drug target discovery by magnetic nanoparticles coupled mass spectrometry
Dandan Xia, Baoling Liu, Xiaowei Xu, Ya Ding, Qiuling Zheng
2021, 11(1): 122-127. doi: 10.1016/j.jpha.2020.02.002
Abstract:
Drug target discovery is the basis of drug screening. It elucidates the cause of disease and the mechanism of drug action, which is the essential of drug innovation. Target discovery performed in biological systems is complicated as proteins are in low abundance and endogenous compounds may interfer...