Synthesis and electrochemical properties of environmental free l-glutathione grafted graphene oxide/ZnO nanocomposite for highly selective piroxicam sensing

N. Dhanalakshmi; T. Priya; S. Thennarasu; S. Sivanesan; N. Thinakaran

doi:10.1016/j.jpha.2020.02.001

Volume 11 Issue 1

Feb. 2021

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N. Dhanalakshmi, T. Priya, S. Thennarasu, S. Sivanesan, N. Thinakaran. Synthesis and electrochemical properties of environmental free l-glutathione grafted graphene oxide/ZnO nanocomposite for highly selective piroxicam sensing[J]. Journal of Pharmaceutical Analysis, 2021, 11(1): 48-56. doi: 10.1016/j.jpha.2020.02.001

Citation:

N. Dhanalakshmi, T. Priya, S. Thennarasu, S. Sivanesan, N. Thinakaran. Synthesis and electrochemical properties of environmental free l-glutathione grafted graphene oxide/ZnO nanocomposite for highly selective piroxicam sensing[J]. Journal of Pharmaceutical Analysis, 2021, 11(1): 48-56. doi: 10.1016/j.jpha.2020.02.001

Citation:

N. Dhanalakshmi, T. Priya, S. Thennarasu, S. Sivanesan, N. Thinakaran. Synthesis and electrochemical properties of environmental free l-glutathione grafted graphene oxide/ZnO nanocomposite for highly selective piroxicam sensing[J]. Journal of Pharmaceutical Analysis, 2021, 11(1): 48-56. doi: 10.1016/j.jpha.2020.02.001

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Synthesis and electrochemical properties of environmental free l-glutathione grafted graphene oxide/ZnO nanocomposite for highly selective piroxicam sensing

doi: 10.1016/j.jpha.2020.02.001

a. Environmental Research Lab, PG and Research Department of Chemistry, Alagappa Government Arts College, Karaikudi, 630 003, Tamil Nadu, India;
b. School of Chemistry, Bharathidasan University, Thiruchirapalli, 620 024, Tamil Nadu, India;
c. Department of Applied Science and Technology, AC Tech, Anna University, Chennai, 25, India

Funds:

This work was supported by SERB (Science and Engineering Research Board), New Delhi, India [File. No: EMR/2014/000020].

Received Date: Oct. 10, 2019
Accepted Date: Feb. 03, 2020
Rev Recd Date: Nov. 28, 2019
Available Online: Jan. 24, 2022
Publish Date: Feb. 15, 2021

Abstract

Abstract

A simple and reliable strategy was proposed to engineer the glutathione grafted graphene oxide/ZnO nanocomposite (glutathione-GO/ZnO) as electrode material for the high-performance piroxicam sensor. The prepared glutathione-GO/ZnO nanocomposite was well characterized by X-ray diffraction (XRD), Fourier transform infrared spectrum (FTIR), X-ray photoelectron spectroscopy (XPS), field emission scanning electron microscopy (FE-SEM), cyclic voltammetry (CV), electrochemical impedance spectroscopy (EIS) and differential pulse voltammetry (DPV). The novel nanocomposite modified electrode showed the highest electrocatalytic activity towards piroxicam (oxidation potential is 0.52 V). Under controlled experimental parameters, the proposed sensor exhibited good linear responses to piroxicam concentrations ranging from 0.1 to 500 μM. The detection limit and sensitivity were calculated as 1.8 nM and 0.2 μA/μM·cm², respectively. Moreover, it offered excellent selectivity, reproducibility, and long-term stability and can effectively ignore the interfering candidates commonly existing in the pharmaceutical tablets and human fluids even at a higher concentration. Finally, the reported sensor was successfully employed to the direct determination of piroxicam in practical samples.
- Reduced graphene oxide,
- Glutathione,
- ZnO,
- Piroxicam,
- Electrochemical sensing

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References(40)

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