2019 Vol. 9, No. 3

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Journal of Pharmaceutical Analysis
2019, 9(3): 封3-封4.
Abstract(71) PDF(1)
Abstract:
Comparison of ELISA and HPLC-MS methods for the determination of exenatide in biological and biotechnology-based formulation matrices
A.R. Pinho, A. Fortuna, A. Falc(a)o, A.C. Santos, R. Sei(c)a, C. Estevens, F. Veiga, A.J. Ribeiro
2019, 9(3): 143-155.
Abstract(161) PDF(8) [Cited by] (23)
Abstract:
The development of biotechnology-based active pharmaceutical ingredients, such as GLP-1 analogs, brought changes in type 2 diabetes treatment options. For better therapeutic efficiency, these active pharmaceutical ingredients require appropriate administration, without the development of adverse eff...
Qualitative and quantitative assessment of related substances in the Compound Ketoconazole and Clobetasol Propionate Cream by HPLC-TOF-MS and HPLC
Wenling Yang, Xiaomei Yang, Fanghua Shi, Zhigang Liao, Yongkun Liang, Liangzhong Yu, Ruixun Wang, Qing Li, Kaishun Bi
2019, 9(3): 156-162.
Abstract(240) PDF(17) [Cited by] (17)
Abstract:
Related substances in pharmaceutical formulations are associated with their safety, efficacy and stability. However, there is no overall study already published on the assessment of related substances in the Compound Ketoconazole and Clobetasol Propionate Cream. In this work, a reliable HPLC-TOF-MS ...
Development and validation of an LC-MS/MS method for tyrphostin A9
Lyndsey F. Meyer, Dhaval K. Shah
2019, 9(3): 163-169.
Abstract(145) PDF(8) [Cited by] (2)
Abstract:
Here we have presented a sensitive and selective LC-MS/MS method for the quantification of tyrphostin A9, which is a selective inhibitor for platelet derived growth factor receptor tyrosine kinase and has been investigated in vitro as a potent oxidative phosphorylation uncoupler. The murine analytic...
Prospects to the formation and control of potential dimer impurity E of pantoprazole sodium sesquihydrate
Arun Kumar Awasthi, Lalit Kumar, Punit Tripathi, Madhava Golla, Cirandur Suresh Reddy, Pramod Kumar
2019, 9(3): 170-177.
Abstract(185) PDF(16) [Cited by] (3)
Abstract:
Pantoprazole sodium, a substituted benzimidazole derivative, is an irreversible proton pump inhibitor which is primarily used for the treatment of duodenal ulcers, gastric ulcers, and gastroesophageal reflux disease (GERD). The monographs of European Pharmacopoeia (Ph. Eur.) and United States Pharma...
Compatibility of rubber stoppers for recombinant antitumor-antivirus protein injection by gas chromatography-mass spectrometry
Zhaorui Meng, Xun Gao, Haifeng Yu, Lan Zhang, Xiangyong Yu, Longshan Zhao
2019, 9(3): 178-184.
Abstract(188) PDF(1) [Cited by] (6)
Abstract:
A simple, rapid, and sensitive gas chromatography-mass spectrometry (GC-MS) method was developed and validated for the simultaneous determination of two fatty acids, methyl hexadecanoate (MH) and methyl stearate (MS), to allow the evaluation of packaging-drug compatibility. The two migrants were qua...
Preparation of polypyrrole/nanosilica composite for solid-phase microextraction of bisphenol and phthalates migrated from containers to eye drops and injection solutions
Mehdi Ansari Dogaheh, Mansoureh Behzadi
2019, 9(3): 185-192.
Abstract(79) PDF(2) [Cited by] (17)
Abstract:
This paper describes the electrodeposition of polyphosphate-doped polypyrrole/nanosilica nano-composite coating on steel wire for direct solid-phase microextraction of bisphenol A and five phthalates. We optimized influencing parameters on the extraction efficiency and morphology of the nanocomposit...
Effect of an extraction solvent on the antioxidant quality of Pinus densiflora needle extract
Thamizhiniyan Venkatesan, Young-Woong Choi, Young-Kyoon Kim
2019, 9(3): 193-200.
Abstract(92) PDF(2) [Cited by] (18)
Abstract:
Pinus densiflora needle extract (PDNE) is widely reported to have many pharmacological activities including antioxidant potential. However, the solvent system used for extraction greatly affects its antioxidant quality. Hence, in the present study, we investigated the effect of a different ratio (vo...
Anticancer potential of metabolic compounds from marine actinomycetes isolated from Lagos Lagoon sediment
Olabisi Flora Davies-Bolorunduro, Isaac Adeyemi Adeleye, Moshood Olushola Akinleye, Peng George Wang
2019, 9(3): 201-208.
Abstract(151) PDF(3) [Cited by] (44)
Abstract:
Thirty-two actinomycetes strains were isolated from sediment samples from 12 different sites at Lagos Lagoon and identified using standard physiological and biochemical procedures as well as 16S rDNA gene sequence analysis. Secondary metabolites were extracted from the strains and their anticancer a...
Synthesis of highly fluorescent carbon dots from lemon and onion juices for determination of riboflavin in multivitamin/mineral supplements
Severino S. Monte-Filho, Stefani I.E. Andrade, Marcelo B. Lima, Mario C.U. Araujo
2019, 9(3): 209-216.
Abstract(218) PDF(17) [Cited by] (125)
Abstract:
In this work, lemon and onion biomasses commonly found in street markets are for the first time used to develop a facile, fast and low-cost one-step microwave-assisted carbonization method for synthesis of highly fluorescent carbon dots (CDs). The structure and optical properties of CDs were investi...

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