Abstract: A fast screening protocol was developed for the simultaneous determination of nine antiestrogenic agents (aminoglutethimide,anastrozole,clomiphene,drostanolone,formestane,letrozole,mesterolone,tamoxifen,testolactone) plus five of their metabolites in human urine.After an enzymatic hydrolysis,these c...
Abstract: A simple,rapid,accurate and highly sensitive spectrofluorimetric method has been developed for determination of some angiotensin Ⅱ receptor antagonists (AIIRA's),namely Losartan potassium (Los-K),Irbesartan (Irb),Valsartan (Val) and Candesartan cilexetil (Cand) in pure forms as well as in their phar...
Abstract: A selective precolumn derivatization liquid chromatography-tandem mass spectrometric (LC-MS/MS) method for the determination of glucosamine in human plasma and urine has been developed and validated.Glucosamine was derivatized by o-phthalaldehyde/3-mercaptopropionic acid.Chromatographic separation w...
Abstract: Didanosine is an effective antiviral drug in untreated and antiretroviral therapy-experienced patients with Human Immunodeficiency Virus (HIV).An automated system using on-line solid extraction and High performance Liquid Chromatography (HPLC) with ultraviolet (UV) detection was developed and valida...
Abstract: Millettia nitida var.hirsutissima is a Chinese herbal medicine used for the treatment of gynecological diseases.An HPLC/DAD/ESI-MSn method was established for the rapid separation and characterization of bioactive flavonoids in M.nitida var.hirsutissima.A total of 32 flavonoids were detected,of whic...
Abstract: This paper describes a sensitive spectrophotometric method developed for determination of Ketoconazole (KC) in tablets based on amplification reactions.Ketoconazole was oxidized with periodate,resulting in formation of KC2+ and iodate ions.After masking the excess periodate with molybdate,the iodate...
Abstract: The enantiomers separation of thirteen drugs collected in Ch.P2010 was performed on chiral stationary phase of cellulose ramification (chiralpak OD and chiralpak OJ) by high performance liquid chromatographic (HPLC) methods,which included ibuprofen (Cl),ketoprofen (C2),nitrendipine (C3),nimodipine (...
Abstract: A sensitive electroanalytical method for quantification of pheniramine in pharmaceutical formulation has been investigated on the basis of the enhanced electrochemical response at glassy carbon electrode modified with multi-walled carbon nanotubes in the presence of sodium lauryl sulfate.The experim...
Abstract: A fast,simple and sensitive high performance liquid chromatographic (HPLC) method has been developed for determination of 10α-methoxy-6-methyl ergoline-8β-methanol (MDL,a main metabolite of nicergoline) in human plasma.One-step liquid-liquid extraction (LLE) with diethyl ether was employed as the sa...
Abstract: A simple,precise,accurate,and stability-indicating method is developed and validated for analysis of tetrahydrozoline hydrochloride in eye drop formulations.Separation was achieved on a reversed-phase C8 column (125 mm × 4.6 mm i.d.,5 μm) using a mobile phase consisting of acetonitrile/phosphate buf...
Abstract: Objective:To develop the representative fingerprint for the quality control of placenta polypeptide injection.Methods:The chromatographic separation was performed using a Phenomenex Gemini C18 column (250 mm × 4.6 mm,5 μm) maintained at 30 ℃.0.1% aqueous trifluoroacetic acid (Solvent A) and acetonit...
Abstract: An efficient method is provided to detect simultaneously some important veterinary drugs from different classes in highly complex animal tissue matrix.This method using matrix solid-phase dispersion (MSPD) and high performance liquid chromatography (HPLC) with diode array detection (DAD) is develope...
