Patitapabana Parida, Subash Chandra Mishra, Subhashree Sahoo, Ajit Behera, Bibhukalyan Prasad Nayak. Development and characterization of ethylcellulose based microsphere for sustained release of nifedipine$[J]. Journal of Pharmaceutical Analysis, 2016, 5(5): 341-344.
Citation:
Patitapabana Parida, Subash Chandra Mishra, Subhashree Sahoo, Ajit Behera, Bibhukalyan Prasad Nayak. Development and characterization of ethylcellulose based microsphere for sustained release of nifedipine$[J]. Journal of Pharmaceutical Analysis, 2016, 5(5): 341-344.
Patitapabana Parida, Subash Chandra Mishra, Subhashree Sahoo, Ajit Behera, Bibhukalyan Prasad Nayak. Development and characterization of ethylcellulose based microsphere for sustained release of nifedipine$[J]. Journal of Pharmaceutical Analysis, 2016, 5(5): 341-344.
Citation:
Patitapabana Parida, Subash Chandra Mishra, Subhashree Sahoo, Ajit Behera, Bibhukalyan Prasad Nayak. Development and characterization of ethylcellulose based microsphere for sustained release of nifedipine$[J]. Journal of Pharmaceutical Analysis, 2016, 5(5): 341-344.
Department of Biotechnology and Medical Engineering,NIT Rourkela,0disha 769008,India
Department of Metal urgical and Materials Engineering,NIT Rourkela,0disha 769008,India
Department of Pharmaceutics,Kanakmanjari Institute of Pharmaceutical Sciences,Rourkela,0disha 769015,India;寺Department of Metal urgical and Materials Engineering,I T Kharagpur,West Bengal 721302,India
This article introduced the work of ethylcellulose based polymeric microsphere loaded with nifedipine for reduction in frequency of administration with low solubility in aqueous medium and high rate of absorption in the stomach. The non-aqueous polymeric suspension was put dropwise into an aqueous medium containing polyvinyl alcohol as a surfactant for the synthesis of microsphere by solvent eva-poration. The microspheres were characterized by different techniques, namely, XRD, SEM, and NMR. The formation of microspheres was confirmed by SEM. XRD analysis revealed the semi-crystallinity nature of microspheres. The NMR study indicated the presence of hetero-aromatic nucleus in the microsphere.