Volume 5 Issue 3
Jun.  2015
Turn off MathJax
Article Contents
Bilal Yilmaz, Ulvihan Ciltas. Determination of diclofenac in pharmaceutical preparations by voltammetry and gas chromatography methods[J]. Journal of Pharmaceutical Analysis, 2015, (3): 153-160.
Citation: Bilal Yilmaz, Ulvihan Ciltas. Determination of diclofenac in pharmaceutical preparations by voltammetry and gas chromatography methods[J]. Journal of Pharmaceutical Analysis, 2015, (3): 153-160.

Determination of diclofenac in pharmaceutical preparations by voltammetry and gas chromatography methods

  • Publish Date: Jun. 10, 2015
  • Rapid, sensitive and specific methods were developed for the determination of diclofenac in pharmaceutical preparations by linear sweep voltammetry (LSV) and gas chromatography (GC) with mass spectrometry (MS) detection. The linearity was established over the concentration range of 5–35μg/mL for LSV and 0.25–5μg/mL for GC–MS method. The intra- and inter-day relative standard deviation (RSD) was less than 4.39% and 4.62% for LSV and GC–MS, respectively. Limits of quantification (LOQ) were determined as 4.8 and 0.15μg/mL for LSV and GC–MS, respectively. No interference was found from tablet excipients at the selected assay conditions. The methods were applied for the quality control of commercial diclofenac dosage forms to quantify the drug and to check the formulation content uniformity.
  • loading
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Article Metrics

    Article views (81) PDF downloads(0) Cited by()
    Proportional views
    Related

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return