The role of NRF2 in human cancers: Pre-clinical insights paving the way for clinical trials

doi: 10.1016/j.jpha.2025.101358

• Yi Pei^a , 
• Jianqiao Yin^b , 
• Jiamei Liu^c , 
• Dongze Liu^d , 
• Qianlong Wu^d , 
• Xue Cai^e , 
• Mingming Han^f , 
• Yu Tian^{g,h ,  ,}  , 
• Liyu Yang^{d ,  ,}  , 
• Shengye Liu^{d ,  ,} 

• a Departments of Bone and Soft Tissue Surgery, Cancer Hospital of China Medical University;

• Liaoning Cancer Hospital & Institute, Shenyang, 110042, China;

• b Department of Oncology, Shengjing Hospital, China Medical University, Shenyang, 110004, China;

• c Department of Pathology, Shengjing Hospital, China Medical University, Shenyang, 110004, China;

• d Department of Orthopedics, Shengjing Hospital, China Medical University, Shenyang, 110004, China;

• e Department of Psychosomatic Medicine, The Huizhou Second People's Hospital, Huizhou, Guangdong, 516001, China;

• f Department of Pharmacy and Medical Devices, Shandong Academy of Occupational Health and Occupational Medicine, Occupational Disease Hospital of Shandong First Medical University (Shandong Province Hospital Occupational Disease Hospital), Jinan, 250002, China;

• g School of Public Health, Benedictine University, Lisle, IL, 60532, USA;

• h Research Center, The Huizhou Central People's Hospital, Guangdong Medical University, Huizhou, Guangdong, 516001, China