Pharmacokinetics, efficacy, and safety of a novel aripiprazole microsphere-based long-acting injectable formulation for schizophrenia: A multicenter, randomized controlled trial

doi: 10.1016/j.jpha.2025.101350

• An-Ning Li¹ , 
• Sheng-Chun Jin² , 
• De-Wei Shang³ , 
• Jian-Xiong Guo⁴ , 
• Hua-Li Lin⁵ , 
• Ming Zhang⁶ , 
• Bo Wei⁷ , 
• Feng Wan⁸ , 
• Yun-Long Tan⁹ , 
• Li-Li Wang¹⁰ , 
• Jian-Chu Zhou¹¹ , 
• Ping Liu¹² , 
• Lian-Lian Fan¹³ , 
• Ju-Shui Sun¹⁴ , 
• Bin Chen¹⁵ , 
• Yimin Cui^{16 ,  ,}  , 
• Gang Wang^{1 ,  ,} 

• 1 National Clinical Research Center for Mental Disorders & National Center for Mental Disorders Beijing Anding Hospital Affiliated to Capital Medical University, Beijing, 100088, China;

• 2 Early Intervention Department, The Fourth People's Hospital of Hefei, Hefei, 230022, China;

• 3 Drug Clinical Trial Institution, The Brain Hospital Affiliated to Guangzhou Medical University, Guangzhou, 510370, China;

• 4 Medical Affairs Department, The Brain Hospital Affiliated to Guangzhou Medical University, Guangzhou, 510370, China;

• 5 Women's Psychopsychology Department, Xi'an Mental Health Center, Xi'an, 710061, China;

• 6 Psychiatric Department 6, Shandong Daizhuang Hospital, Jining, Shandong, 272000, China;

• 7 Dean's Office, Jiangxi Provincial Psychiatric Hospital, Nanchang, 220029, China;

• 8 Female Acute Care Ward 3, Shenzhen Kangning Hospital, Shenzhen, Guangdong, 518118, China;

• 9 Vice-president's Office, Beijing Huilongguan Hospital, Beijing, 100096, China;

• 10 Psychiatric Department 8, Tianjin Anding Hospital, Tianjin, 300222, China;

• 11 Vice-president's Office, The 11th People's Hospital of Chongqing, Chongqing, 400030, China;

• 12 Psychosomatic Medicine Department, Deyang People's Hospital, Deyang, Sichuan, 618000, China;

• 13 Drug Clinical Trial Institution, Deyang People's Hospital, Deyang, Sichuan, 618000, China;

• 14 Premium Psychiatric Services Department, The Third People's Hospital of Huzhou, Huzhou, Zhejiang, 313000, China;

• 15 Zhuhai Livzon Microsphere Technology Co., Ltd., Livzon Pharmaceutical Group Inc., Zhuhai, Guangdong, 519090, China;

• 16 Institute of Clinical Pharmacology, Peking University First Hospital, Beijing, 100191, China