TCMKD: From ancient wisdom to modern insights-A comprehensive platform for traditional Chinese medicine knowledge discovery

Wenke Xiao; Mengqing Zhang; Danni Zhao; Fanbo Meng; Qiang Tang; Lianjiang Hu; Hongguo Chen; Yixi Xu; Qianqian Tian; Mingrui Li; Guiyang Zhang; Liang Leng; Shilin Chen; Chi Song; Wei Chen

doi:10.1016/j.jpha.2025.101297

Volume 15 Issue 6

Jun. 2025

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Article Navigation > Journal of Pharmaceutical Analysis > 2025 > 15(6): 101297

Wenke Xiao, Mengqing Zhang, Danni Zhao, Fanbo Meng, Qiang Tang, Lianjiang Hu, Hongguo Chen, Yixi Xu, Qianqian Tian, Mingrui Li, Guiyang Zhang, Liang Leng, Shilin Chen, Chi Song, Wei Chen. TCMKD: From ancient wisdom to modern insights-A comprehensive platform for traditional Chinese medicine knowledge discovery[J]. Journal of Pharmaceutical Analysis, 2025, 15(6): 101297. doi: 10.1016/j.jpha.2025.101297

Citation:

Wenke Xiao, Mengqing Zhang, Danni Zhao, Fanbo Meng, Qiang Tang, Lianjiang Hu, Hongguo Chen, Yixi Xu, Qianqian Tian, Mingrui Li, Guiyang Zhang, Liang Leng, Shilin Chen, Chi Song, Wei Chen. TCMKD: From ancient wisdom to modern insights-A comprehensive platform for traditional Chinese medicine knowledge discovery[J]. Journal of Pharmaceutical Analysis, 2025, 15(6): 101297. doi: 10.1016/j.jpha.2025.101297

Citation:

Wenke Xiao, Mengqing Zhang, Danni Zhao, Fanbo Meng, Qiang Tang, Lianjiang Hu, Hongguo Chen, Yixi Xu, Qianqian Tian, Mingrui Li, Guiyang Zhang, Liang Leng, Shilin Chen, Chi Song, Wei Chen. TCMKD: From ancient wisdom to modern insights-A comprehensive platform for traditional Chinese medicine knowledge discovery[J]. Journal of Pharmaceutical Analysis, 2025, 15(6): 101297. doi: 10.1016/j.jpha.2025.101297

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TCMKD: From ancient wisdom to modern insights-A comprehensive platform for traditional Chinese medicine knowledge discovery

doi: 10.1016/j.jpha.2025.101297

a. State Key Laboratory of Southwestern Chinese Medicine Resources, Innovative Institute of Chinese Medicine and Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, 611137, China;
b. School of Intelligent Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, 611137, China;
c. School of Basic Medical Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu, 611137, China;
d. State Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, 611137, China;
e. State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau, 999078, China;
f. Faculty of Social Sciences, The University of Hong Kong, Hong Kong, 999077, China;
g. Institute of Herbgenomics, Chengdu University of Traditional Chinese Medicine, Chengdu, 611137, China

Funds:

This work was supported by Natural Science Foundation of Sichuan, China (Grant No.: 2024ZDZX0019).

Received Date: Dec. 19, 2024
Accepted Date: Apr. 04, 2025
Rev Recd Date: Mar. 19, 2025
Publish Date: Apr. 10, 2025

Abstract

Abstract

Traditional Chinese medicine (TCM) serves as a treasure trove of ancient knowledge, holding a crucial position in the medical field. However, the exploration of TCM's extensive information has been hindered by challenges related to data standardization, completeness, and accuracy, primarily due to the decentralized distribution of TCM resources. To address these issues, we developed a platform for TCM knowledge discovery (TCMKD, https://cbcb.cdutcm.edu.cn/TCMKD/). Seven types of data, including syndromes, formulas, Chinese patent drugs (CPDs), Chinese medicinal materials (CMMs), ingredients, targets, and diseases, were manually proofread and consolidated within TCMKD. To strengthen the integration of TCM with modern medicine, TCMKD employs analytical methods such as TCM data mining, enrichment analysis, and network localization and separation. These tools help elucidate the molecular-level commonalities between TCM and contemporary scientific insights. In addition to its analytical capabilities, a quick question and answer (Q&A) system is also embedded within TCMKD to query the database efficiently, thereby improving the interactivity of the platform. The platform also provides a TCM text annotation tool, offering a simple and efficient method for TCM text mining. Overall, TCMKD not only has the potential to become a pivotal repository for TCM, delving into the pharmacological foundations of TCM treatments, but its flexible embedded tools and algorithms can also be applied to the study of other traditional medical systems, extending beyond just TCM.
- Traditional Chinese medicine,
- Data mining,
- Knowledge graph,
- Network visualization,
- Network analysis

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