Screen of FDA-approved drug library identifies Vitamin K as anti-ferroptotic drug for osteoarthritis therapy through Gas6

doi: 10.1016/j.jpha.2024.101092

• Yifeng Shi^a,b,e , 
• Sunlong Li^a,b,e , 
• Shuhao Zhang^a,b,e , 
• Caiyu Yu^f , 
• Jiansen Miao^a,b,e , 
• Shu Yang^a,b,e , 
• Yan Chen^a,b,e , 
• Yuxuan Zhu^a,b,e , 
• Xiaoxiao Huang^g , 
• Chencheng Zhou^e , 
• Hongwei Ouyang^{c,d ,  ,}  , 
• Xiaolei Zhang^{a,b,e ,  ,}  , 
• Xiangyang Wang^{a,b,e ,  ,} 

• a Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, 325000, China;

• b Key Laboratory of Orthopaedics of Zhejiang Province, Wenzhou, 325000, China;

• c Dr. Li Dak Sum & Yip Yio Chin Center for Stem Cells and Regenerative Medicine, Zhejiang University School of Medicine, Hangzhou, 310058, China;

• d Zhejiang University-University of Edinburgh Institute (ZJU-UoE Institute), Zhejiang University School of Medicine, Hangzhou, 310058, China;

• e The Second School of Medicine, Wenzhou Medical University, Wenzhou, 325003, China;

• f School of Ophthalmology and Optometry and Eye Hospital, Wenzhou Medical University, Wenzhou, 325003, China;

• g The First School of Medicine, Wenzhou Medical University, Wenzhou, 325003, China