Discovery of potent anti-MRSA components from Dalbergia odorifera through UPLC-Q-TOF-MS and targeting PBP2a protein through in-depth transcriptomic, in vitro, and in-silico studies

Jiajia Wu; Syed Shams ul Hassan; Xue Zhang; Tao Li; Abdur Rehman; Shikai Yan; Huizi Jin

doi:10.1016/j.jpha.2024.01.006

Volume 14 Issue 8

Aug. 2024

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Jiajia Wu, Syed Shams ul Hassan, Xue Zhang, Tao Li, Abdur Rehman, Shikai Yan, Huizi Jin. Discovery of potent anti-MRSA components from Dalbergia odorifera through UPLC-Q-TOF-MS and targeting PBP2a protein through in-depth transcriptomic, in vitro, and in-silico studies[J]. Journal of Pharmaceutical Analysis, 2024, 14(8): 100938. doi: 10.1016/j.jpha.2024.01.006

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Jiajia Wu, Syed Shams ul Hassan, Xue Zhang, Tao Li, Abdur Rehman, Shikai Yan, Huizi Jin. Discovery of potent anti-MRSA components from Dalbergia odorifera through UPLC-Q-TOF-MS and targeting PBP2a protein through in-depth transcriptomic, in vitro, and in-silico studies[J]. Journal of Pharmaceutical Analysis, 2024, 14(8): 100938. doi: 10.1016/j.jpha.2024.01.006

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Discovery of potent anti-MRSA components from Dalbergia odorifera through UPLC-Q-TOF-MS and targeting PBP2a protein through in-depth transcriptomic, in vitro, and in-silico studies

doi: 10.1016/j.jpha.2024.01.006

a. Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs, School of Pharmacy, Shanghai Jiao Tong University, Shanghai, 200240, China;
b. Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai, 200241, China;
c. College of Life Sciences, Northwest A&F University, Yangling, Shaanxi, 712100, China

Funds:

We are extremely grateful to the National Natural Science Foundation of China (Grant No.: 81973191), Shanghai Agriculture Applied Technology Development Program, China (Program No.: T20200104), and the National Key Research and Development Program of China (Program No.: 2018YFE0192600) for providing financial support for the complete undertaking.

Received Date: Sep. 09, 2023
Accepted Date: Jan. 17, 2024
Rev Recd Date: Jan. 07, 2024
Publish Date: Jan. 23, 2024

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References

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