Volume 13 Issue 7
Jul.  2023
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Article Navigation >  Journal of Pharmaceutical Analysis  > 2023  >  13(7): 788-805
He Li, Tianyuan Ye, Xingyang Liu, Rui Guo, Xiuzhao Yang, Yangyi Li, Dongmei Qi, Yihua Wei, Yifan Zhu, Lei Wen, Xiaorui Cheng. The role of signaling crosstalk of microglia in hippocampus on progression of ageing and Alzheimer's disease[J]. Journal of Pharmaceutical Analysis, 2023, 13(7): 788-805. doi: 10.1016/j.jpha.2023.05.008
Citation: He Li, Tianyuan Ye, Xingyang Liu, Rui Guo, Xiuzhao Yang, Yangyi Li, Dongmei Qi, Yihua Wei, Yifan Zhu, Lei Wen, Xiaorui Cheng. The role of signaling crosstalk of microglia in hippocampus on progression of ageing and Alzheimer's disease[J]. Journal of Pharmaceutical Analysis, 2023, 13(7): 788-805. doi: 10.1016/j.jpha.2023.05.008
shu

The role of signaling crosstalk of microglia in hippocampus on progression of ageing and Alzheimer's disease

doi: 10.1016/j.jpha.2023.05.008

  • a. Innovative Institute of Chinese Medicine and Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan, 250355, China;

  • b. Xiamen Key Laboratory for TCM Dampness Disease, Neurology & Immunology Research, Department of Traditional Chinese Medicine, Xiang'an Hospital, School of Medicine, Xiamen University, Xiamen, Fujian, 361102, China;

  • c. Experimental Center, Shandong University of Traditional Chinese Medicine, Jinan, 250355, China

Funds:

This work was supported by grants from the Key R&D Plan of the Science and Technology Plan of Tibet Autonomous Region, China (Grant No.: XZ202201ZY0026G), the Science and Technology Cooperation Project of Shandong Provincial Department of Science and Technology for Counterpart Assistance to Tibet, China (Grant No.: YDZX2021083), the National Natural Science Foundation of China (Grant No.: 82205078), and the Natural Science Foundation of Shandong Province, China (Grant No.: ZR2021QH157). Professor Yide Zeng from Innovation Research Institute of Shandong University of Traditional Chinese Medicine provided support for immunofluorescence equipment. Animal specific pathogen free feeding environment was provided by the Experimental Center of Shandong University of Traditional Chinese Medicine (Jinan, China).

  • Received Date: Dec. 29, 2022
  • Accepted Date: May 12, 2023
  • Rev Recd Date: May 08, 2023
  • Available Online: Aug. 05, 2023
  • Publish Date: May 15, 2023
    Abstract
  • Based on single-cell sequencing of the hippocampi of 5× familiar Alzheimer's disease (5× FAD) and wild type mice at 2-, 12-, and 24-month of age, we found an increased percentage of microglia in aging and Alzheimer's disease (AD) mice. Blood brain barrier injury may also have contributed to this increase. Immune regulation by microglia plays a major role in the progression of aging and AD, according to the functions of 41 intersecting differentially expressed genes in microglia. Signaling crosstalk between C−C motif chemokine ligand (CCL) and major histocompatibility complex-1 bridges intercellular communication in the hippocampus during aging and AD. The amyloid precursor protein (APP) and colony stimulating factor (CSF) signals drive 5× FAD to deviate from aging track to AD occurrence among intercellular communication in hippocampus. Microglia are involved in the progression of aging and AD can be divided into 10 functional types. The strength of the interaction among microglial subtypes weakened with aging, and the CCL and CSF signaling pathways were the fundamental bridge of communication among microglial subtypes.
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