Resveratrol elongates the lifespan and improves antioxidant activity in the silkworm <i>Bombyx mori</i>

Jiangbo Song; Lian Liu; Kaige Hao; Shuang Mao; Yongxi Tang; Xiaoling Tong; Fangyin Dai

doi:10.1016/j.jpha.2020.06.005

Volume 11 Issue 3

Jun. 2021

Turn off MathJax

Article Contents

Article Navigation > Journal of Pharmaceutical Analysis > 2021 > 11(3): 374-382

Jiangbo Song, Lian Liu, Kaige Hao, Shuang Mao, Yongxi Tang, Xiaoling Tong, Fangyin Dai. Resveratrol elongates the lifespan and improves antioxidant activity in the silkworm Bombyx mori[J]. Journal of Pharmaceutical Analysis, 2021, 11(3): 374-382. doi: 10.1016/j.jpha.2020.06.005

Citation:

Jiangbo Song, Lian Liu, Kaige Hao, Shuang Mao, Yongxi Tang, Xiaoling Tong, Fangyin Dai. Resveratrol elongates the lifespan and improves antioxidant activity in the silkworm Bombyx mori[J]. Journal of Pharmaceutical Analysis, 2021, 11(3): 374-382. doi: 10.1016/j.jpha.2020.06.005

Citation:

PDF( 2303 KB)

Resveratrol elongates the lifespan and improves antioxidant activity in the silkworm Bombyx mori

doi: 10.1016/j.jpha.2020.06.005

State Key Laboratory of Silkworm Genome Biology; Key Laboratory for Sericulture Biology and Genetic Breeding, Ministry of Agriculture and Rural Affairs; College of Biotechnology, Southwest University, No. 2 Tiansheng Road, Beibei District, Chongqing, 400715, China

Funds:

We thank Jianfei Zhang and Zheng Li for providing assistance with the figures. This work was supported by the National Natural Science Foundation of China (Grant Nos. 31830094 and 31902215), the Hi-Tech Research and Development 863 Program of China (Grant No. 2013AA102507), the Fundamental Research Funds for the Central Universities in China (No. XDJK2019C014), Project funded by Chongqing Special Postdoctoral Science Foundation (Grant No. XmT2018058), and Funds of China Agricultural Research System (No. CARS-18-ZJ0102).

Received Date: Dec. 29, 2019
Accepted Date: Jun. 27, 2020
Rev Recd Date: Jun. 26, 2020
Available Online: Jan. 24, 2022
Publish Date: Jun. 15, 2021

Abstract

Abstract

A number of research has shown that the plant polyphenol resveratrol, one of the most prominent small molecules, has beneficial protective effects in multiple organisms, including worms, flies, and killifish. To understand the effects of resveratrol on lifespan, we evaluated its effects in the silkworm Bombyx mori. In this study, we found that lifespan was significantly prolonged in both female and male silkworms treated with resveratrol. Silkworm larval weight was significantly increased from day 3 of the 5th larval instar (L5D3) to day 7 of the 5th larval instar (L5D7). However, the weight of the pupa, cocoon, and total cocoon was not significantly different in female silkworms with resveratrol treatment than that in controls. Meanwhile, resveratrol significantly improved the thermotolerance of the silkworms, which enhanced their survival rate. Moreover, antioxidant activity was increased by resveratrol in both female and male silkworms. Furthermore, an antioxidant-related signalling pathway, SIRT7-FoxO-GST, was activated in silkworms with resveratrol treatment. Collectively, these results help us to understand the molecular pathways underlying resveratrol induced pro-longevity effects and indicate that silkworm is a promising animal model for evaluating the effects of lifespan-extending drugs.
- Resveratrol,
- Bombyx mori,
- Lifespan,
- Antioxidant activity,
- SIRT7-FoxO-GST pathway

FullText(HTML)

References(34)

References

M. Takaoka, The phenolic substances of White Hellebore (Veratrum Grandiflorum Hoes. Fil.) I., Nippon Kagaku Kaishi 3 (1939) 1090-1100

S. Nonomura, H. Kanagawa, A. Makimoto, Chemical constituents of polygonaceous plants. I. Studies on the components of ko-jo-kon, Yakugaku Zasshi 83 (1963) 988-990

B.P. Hubbard, D.A. Sinclair, Small molecule SIRT1 activators for the treatment of aging and age-related diseases, Trends Pharmacol. Sci. 35 (2014) 146-154

E.H. Siemann, L.L. Creasy, Concentration of the phytoalexin resveratrol in wine, Am. J. Enoi. Vitic. 43 (1992) 49-52

B.L. Liu, X. Zhang, W. Zhang, et al., New enlightenment of French Paradox: resveratrol’s potential for cancer chemoprevention and anti-cancer therapy, Cancer Biol. Ther. 6 (2007) 1833-1836

M. Jang, L. Cai, G.O. Udeani, et al., Cancer chemopreventive activity of resveratrol, a natural product derived from grapes, Science 275 (1997) 218-220

T.M. Bass, D. Weinkove, K. Houthoofd, et al., Effects of resveratrol on lifespan in Drosophila melanogaster and Caenorhabditis elegans, Mech. Ageing Dev. 128 (2007) 546-552

C. Carles, A. Johan, Targeting sirtuin 1 to improve metabolism: all you need is NAD (+)?, Pharmacol. Rev. 64 (2012) 166-187

K. Pallauf, G. Rimbacha, P.M. Ruppa, et al., Resveratrol and Lifespan in Model Organisms, Curr. Med. Chem. 23 (2016) 4639-4680

K.T. Howitz, K.J. Bitterman, H.Y. Cohen, et al., Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan, Nature 425 (2003) 191-196

J.A. Baur, K.J. Pearson, N.L. Price, et al., Resveratrol improves health and survival of mice on a high-calorie diet, Nature 444 (2006) 337-342

L. Marie, A. Carmen, G.H. Zachary, et al., Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1α, Cell 127 (2006) 1109-1122

H.A. Tissenbaum, L. Guarente, Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans, Nature 410 (2001) 227-230

C.J. Kenyon, The genetics of ageing, Nature 464 (2010) 504-512

B. Agarwal, J.A. Baur, Resveratrol and life extension, Ann. NY. Acad. Sci. 1215 (2011) 138-143

D.R. Valenzano, E. Terzibasi, T. Genade, et al., Resveratrol prolongs lifespan and retards the onset of age-related markers in a short-lived vertebrate, Curr. Biol. 16 (2006) 296-300

B. Rascon, B.P. Hubbard, D.A. Sinclair, et al., The lifespan extension effects of resveratrol are conserved in the honey bee and may be driven by a mechanism related to caloric restriction, Aging 4 (2012) 499-508

C.B. Brachmann, J.M. Sherman, S.E. Devine, et al., The SIR2 gene family, conserved from bacteria to humans, functions in silencing, cell cycle progression, and chromosome stability, Genes Dev. 9 (1995) 2888-2902

R.H. Cherry, History of Sericulture, B. Entomol. Soc. Am. 33 (1987) 83-85

C. Chen, J.B. Song, M. Chen, et al., Rhodiola rosea extends lifespan and improves stress tolerance in silkworm, Bombyx mori, Biogerontology 17 (2016) 373-381

J.B. Song, G.H. Jiang, J.F. Zhang, et al., Metformin prolongs lifespan through remodeling the energy distribution strategy in silkworm, Bombyx mori, Aging (Albany NY) 11 (2019) 240-248

J.B. Song, M. Chen, Z.Q. Li, et al., Astragalus polysaccharide extends lifespan via mitigating endoplasmic reticulum stress in the silkworm, Bombyx mori. Aging Dis. 10 (2019) 1187-1198

J.B. Song, J.F. Zhang, F.Y. Dai, Advantages and limitations of silkworm as an invertebrate model in aging and lifespan research. Open Access J. Gerontol. Geriatr. Med. 4 (2018) 555641

J.B. Song, D.M. Tang, Z.Q. Li, et al., Variation of lifespan in multiple strains, and effects of dietary restriction and BmFoxO on lifespan in silkworm, Bombyx mori, Oncotarget 8 (2016) 7294-7300

G.H. Wang, Q.Y. Xia, D.J. Cheng, et al., Reference genes identified in the silkworm Bombyx mori during metamorphism based on oligonucleotide microarray and confirmed by qRT-PCR, Insect Sci. 15 (2008) 405-413

M. Gonzalez-Freire, A. Diaz-Ruiz, D. Hauser, et al., The road ahead for health and lifespan interventions, Ageing Res. Rev. 59 (2020) 101037

S.D.L. Postnikoff, M.E. Malo, W. Berchman, et al., The yeast forkhead transcription factors fkh1 and fkh2 regulate lifespan and stress response together with the anaphase-promoting complex. PLoS Genet. 8 (2012) e1002583

K. Fukuhara, I.A. Nakanishi, T. Matsumura, et al., Effect of methyl substitution on the antioxidative property and genotoxicity of resveratrol, Chem. Res. Toxicol. 21 (2008) 282-287

D. Vilchez, I. Morantte, Z. Liu, et al., RPN-6 determines C. elegans longevity under proteotoxic stress conditions, Nature 489 (2012) 263-268

S.M. Solon-Biet, K.A. Walters, U.K. Simanainen, et al., Macronutrient balance, reproductive function, and lifespan in aging mice, Proc. Natl. Acad. Sci. U S A. 112 (2015) 3481-3486

G. Jasienska, Reproduction and lifespan: Trade-offs, overall energy budgets, intergenerational costs, and costs neglected by research, Am. J. Hum. Biol. 21 (2010) 524-532

D. Harman, Aging: a theory based on free radical and radiation chemistry, J. Gerontol. 11 (1956) 298-300

J.M.A. Tullet, DAF-16 target identification in C. elegans: past, present and future, Biogerontology 16 (2015) 221-234

C.T. Murphy, S.A. Mccarroll, C.I. Bargmann, et al., Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans, Nature 424 (2003) 277-283

Relative Articles

Supplements(0)

Cited By

Proportional views