Prajesh Prajapati, Vipul Vaghela, Deepak Rawtani, Harshad Patel, Jasmin Kubavat, Dharmendra Baraiya. Azeotropic mixture used for development and validation of Lornoxicam in bulk and its tablet dosage form by spectrophotometric method[J]. Journal of Pharmaceutical Analysis, 2012, 02(4): 306-309. doi: 10.1016/j.jpha.2012.02.004
Citation:
Prajesh Prajapati, Vipul Vaghela, Deepak Rawtani, Harshad Patel, Jasmin Kubavat, Dharmendra Baraiya. Azeotropic mixture used for development and validation of Lornoxicam in bulk and its tablet dosage form by spectrophotometric method[J]. Journal of Pharmaceutical Analysis, 2012, 02(4): 306-309. doi: 10.1016/j.jpha.2012.02.004
Prajesh Prajapati, Vipul Vaghela, Deepak Rawtani, Harshad Patel, Jasmin Kubavat, Dharmendra Baraiya. Azeotropic mixture used for development and validation of Lornoxicam in bulk and its tablet dosage form by spectrophotometric method[J]. Journal of Pharmaceutical Analysis, 2012, 02(4): 306-309. doi: 10.1016/j.jpha.2012.02.004
Citation:
Prajesh Prajapati, Vipul Vaghela, Deepak Rawtani, Harshad Patel, Jasmin Kubavat, Dharmendra Baraiya. Azeotropic mixture used for development and validation of Lornoxicam in bulk and its tablet dosage form by spectrophotometric method[J]. Journal of Pharmaceutical Analysis, 2012, 02(4): 306-309. doi: 10.1016/j.jpha.2012.02.004
Department of Pharmaceutical Analysis, Institute of Research and Development, Gujarat Forensic Sciences University,Sector-18A, Nr. Police bhavan, Gandhinagar 382007, Gujarat, India
A.R. College of Pharmacy and G.H. Patel Institute of Pharmacy, Vallabh Vidyanagar 388120, Gujarat, India
A novel,safe,economic and sensitive method of spectrophotometric estimation has been developed using Azeoptropic mixture (water∶methanol:60∶40,v/v) for the quantitative determination of Lornoxicam,a practically water-insoluble drug.Hence,Lornoxicam stock solution was prepared in Azeoptropic mixture.Lornoxicam showed maximum absorbance at 383 nm.Beer's law was obeyed in the concentration range 4-24 μg/mL with regression coefficient of 0.999.The method was validated in terms of linearity (R2=0.999),precision (CV for intra-day and inter-day was 0.28 0.68 and 0.12-0.92,respectively),accuracy (98.03-100.59% w/w) and specificity.This method is simple,precise,accurate,sensitive and reproducible and can be used for the routine quality control testing of the marketed formulations.