Voltammetric behavior of sedative drug midazolam at glassy carbon electrode in solubilized systems

Rajeev Jain; Rajeev Kumar Yadav

doi:10.1016/j.jpha.2011.11.008

Volume 2 Issue 2

Apr. 2012

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Rajeev Jain, Rajeev Kumar Yadav. Voltammetric behavior of sedative drug midazolam at glassy carbon electrode in solubilized systems[J]. Journal of Pharmaceutical Analysis, 2012, 02(2): 123-129. doi: 10.1016/j.jpha.2011.11.008

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Rajeev Jain, Rajeev Kumar Yadav. Voltammetric behavior of sedative drug midazolam at glassy carbon electrode in solubilized systems[J]. Journal of Pharmaceutical Analysis, 2012, 02(2): 123-129. doi: 10.1016/j.jpha.2011.11.008

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Voltammetric behavior of sedative drug midazolam at glassy carbon electrode in solubilized systems

doi: 10.1016/j.jpha.2011.11.008

School of Studies in Chemistry, Jiwaji University, Gwalior 474011, India

Publish Date: Apr. 10, 2012

Abstract

Abstract

Redox behavior of midazolam was studied at a glassy carbon electrode in various buffer systems,supporting electrolytes and pH using differential paise,square-wave and cyclic voltammetry.Based on its reduction behavior,a direct differential pulse voltammetric method has been developed and validated for the determination of midazolam in parenteral dosage.Three welldefined peaks were observed in 0.1% SLS,Britton-Robinson (BR) buffer of pH 2.5.The effect of surfaetants like sodium lauryl sulfate (SLS),cetyl trimethyl ammonium bromide (CTAB) and Tween 20 was studied.Among these surfactants SLS showed significant enhancement in reduction peak.The cathodic peak currents were directly proportional to the concentration of midazolam with correlation coetfficient of 0.99.
- Midazolam,
- Voltammetry,
- Surfactant,
- Glassy carbon electrode,
- Parenteral dosage form