Emodin is a novel phosphatidylethanolamine anabolism inhibitor that reprograms lipid metabolism to overcome 5-fluorouracil resistance in colorectal cancer

Yanyan Chen; Yanchen Liu; Zhicheng Gong; Zhaohui Huang

doi:10.1016/j.jpha.2025.101343

Article Contents

Article Navigation > Journal of Pharmaceutical Analysis > 2025 > Accepted Manu

Yanyan Chen, Yanchen Liu, Zhicheng Gong, Zhaohui Huang. Emodin is a novel phosphatidylethanolamine anabolism inhibitor that reprograms lipid metabolism to overcome 5-fluorouracil resistance in colorectal cancer[J]. Journal of Pharmaceutical Analysis. doi: 10.1016/j.jpha.2025.101343

Citation:

Yanyan Chen, Yanchen Liu, Zhicheng Gong, Zhaohui Huang. Emodin is a novel phosphatidylethanolamine anabolism inhibitor that reprograms lipid metabolism to overcome 5-fluorouracil resistance in colorectal cancer[J]. Journal of Pharmaceutical Analysis. doi: 10.1016/j.jpha.2025.101343

Citation:

Yanyan Chen, Yanchen Liu, Zhicheng Gong, Zhaohui Huang. Emodin is a novel phosphatidylethanolamine anabolism inhibitor that reprograms lipid metabolism to overcome 5-fluorouracil resistance in colorectal cancer[J]. Journal of Pharmaceutical Analysis. doi: 10.1016/j.jpha.2025.101343

PDF( 17221 KB)

Emodin is a novel phosphatidylethanolamine anabolism inhibitor that reprograms lipid metabolism to overcome 5-fluorouracil resistance in colorectal cancer

doi: 10.1016/j.jpha.2025.101343

Yanyan Chen^a,
Yanchen Liu^a,
Zhicheng Gong^{a,b
,
,},
Zhaohui Huang^{a,b
,
,}

a. Wuxi Cancer Institute, Affiliated Hospital of Jiangnan University, Wuxi, Jiangsu, 214062, China;
b. Laboratory of Cancer Epigenetics, Wuxi School of Medicine, Jiangnan University, Wuxi, Jiangsu, 214122, China

Funds:

This research was financially supported by the National Natural Science Foundation of China (Grant No.: 82274115), Top Talent Support Program for Young and Middle-aged People of Wuxi Health Committee, China (Grant Nos.: BJ2023042 and HB2023060), and Wuxi Medical Key Discipline, China (Grant No.: ZDXK2021002). We thank Associate Professor Kaisa Cui (Affiliated Hospital of Jiangnan University, China) for his kind assistance in data processing.