2024 Vol. 14, No. 6

News
High-strength antiswelling adhesive achieves both hemostasis and wound healing
Xin Zhao, Jinlong Luo, Ying Huang, Lei Mu, Jueying Chen, Zhen Liang, Zhanhai Yin, Dake Chu, Yong Han, Baolin Guo
2024, 14(6): 100955. doi: 10.1016/j.jpha.2024.02.009
Abstract:
Review papers
Basic regulatory science behind drug substance and drug product specifications of monoclonal antibodies and other protein therapeutics
Patanachai K. Limpikirati, Sorrayut Mongkoltipparat, Thinnaphat Denchaipradit, Nathathai Siwasophonpong, Wudthipong Pornnopparat, Parawan Ramanandana, Phumrapee Pianpaktr, Songsak Tongchusak, Maoxin Tim Tian, Trairak Pisitkun
2024, 14(6): 100916. doi: 10.1016/j.jpha.2023.12.006
Abstract:

In this review, we focus on providing basics and examples for each component of the protein therapeutic specifications to interested pharmacists and biopharmaceutical scientists with a goal to strengthen understanding in regulatory science and compliance. Pharmaceutical specifications comprise a lis...

New perspectives on the therapeutic potential of quercetin in non-communicable diseases: Targeting Nrf2 to counteract oxidative stress and inflammation
Li Zhang, Li-Yue Xu, Fei Tang, Dong Liu, Xiao-Lan Zhao, Jing-Nan Zhang, Jia Xia, Jiao-Jiao Wu, Yu Yang, Cheng Peng, Hui Ao
2024, 14(6): 100930. doi: 10.1016/j.jpha.2023.12.020
Abstract:

Non-communicable diseases (NCDs), including cardiovascular diseases, cancer, metabolic diseases, and skeletal diseases, pose significant challenges to public health worldwide. The complex pathogenesis of these diseases is closely linked to oxidative stress and inflammatory damage. Nuclear factor ery...

Bio-soft matter derived from traditional Chinese medicine: Characterizations of hierarchical structure, assembly mechanism, and beyond
Guiya Yang, Yue Liu, Yuying Hu, Yue Yuan, Yunan Qin, Quan Li, Shuangcheng Ma
2024, 14(6): 100943. doi: 10.1016/j.jpha.2024.01.011
Abstract:

Structural and functional explorations on bio-soft matter such as micelles, vesicles, nanoparticles, aggregates or polymers derived from traditional Chinese medicine (TCM) has emerged as a new topic in the field of TCM. The discovery of such cross-scaled bio-soft matter may provide a unique perspect...

Original articles
In situ visualization of the cellular uptake and sub-cellular distribution of mussel oligosaccharides
Zhenjie Yu, Huarong Shao, Xintian Shao, Linyan Yu, Yanan Gao, Youxiao Ren, Fei Liu, Caicai Meng, Peixue Ling, Qixin Chen
2024, 14(6): 100932. doi: 10.1016/j.jpha.2023.12.022
Abstract:

Unlike chemosynthetic drugs designed for specific molecular and disease targets, active small-molecule natural products typically have a wide range of bioactivities and multiple targets, necessitating extensive screening and development. To address this issue, we propose a strategy for the direct in...

Oxalate regulates crystal-cell adhesion and macrophage metabolism via JPT2/PI3K/AKT signaling to promote the progression of kidney stones
Qianlin Song, Chao Song, Xin Chen, Yunhe Xiong, Ziqi He, Xiaozhe Su, Jiawei Zhou, Hu Ke, Caitao Dong, Wenbiao Liao, Sixing Yang
2024, 14(6): 100956. doi: 10.1016/j.jpha.2024.02.010
Abstract:

Oxalate is an organic dicarboxylic acid that is a common component of plant foods. The kidneys are essential organs for oxalate excretion, but excessive oxalates may induce kidney stones. Jupiter microtubule associated homolog 2 (JPT2) is a critical molecule in Ca2+ mobilization, and its intrinsic m...

MGMT activated by Wnt pathway promotes cisplatin tolerance through inducing slow-cycling cells and nonhomologous end joining in colorectal cancer
Haowei Zhang, Qixin Li, Xiaolong Guo, Hong Wu, Chenhao Hu, Gaixia Liu, Tianyu Yu, Xiake Hu, Quanpeng Qiu, Gang Guo, Junjun She, Yinnan Chen
2024, 14(6): 100950. doi: 10.1016/j.jpha.2024.02.004
Abstract:

Chemotherapy resistance plays a pivotal role in the prognosis and therapeutic failure of patients with colorectal cancer (CRC). Cisplatin (DDP)-resistant cells exhibit an inherent ability to evade the toxic chemotherapeutic drug effects which are characterized by the activation of slow-cycle program...

CA IX-targeted Ag2S quantum dots bioprobe for NIR-II imaging-guided hypoxia tumor chemo-photothermal therapy
Xinyue Cui, Zhuang Hu, Ruihan Li, Peng Jiang, Yongchang Wei, Zilin Chen
2024, 14(6): 100969. doi: 10.1016/j.jpha.2024.100969
Abstract:

Hypoxia is the common characteristic of almost all solid tumors, which prevents therapeutic drugs from reaching the tumors. Therefore, the development of new targeted agents for the accurate diagnosis of hypoxia tumors is widely concerned. As carbonic anhydrase IX (CA IX) is abundantly distributed o...

Paeoniflorin ameliorates chronic colitis via the DR3 signaling pathway in group 3 innate lymphoid cells
Shaowei Huang, Xueqian Xie, Bo Xu, Zengfeng Pan, Junjie Liang, Meiling Zhang, Simin Pan, Xiaojing Wang, Meng Zhao, Qing Wang, Jinyan Chen, Yanyang Li, Lian Zhou, Xia Luo
2024, 14(6): 100940. doi: 10.1016/j.jpha.2024.01.008
Abstract:

Inhibiting the death receptor 3 (DR3) signaling pathway in group 3 innate lymphoid cells (ILC3s) presents a promising approach for promoting mucosal repair in individuals with ulcerative colitis (UC). Paeoniflorin, a prominent component of Paeonia lactiflora Pall., has demonstrated the ability to re...

Fangchinoline induces antiviral response by suppressing STING degradation
Jinyong Wang, Fang Xie, Xin Jia, Xuejiao Wang, Lingdong Kong, Yiying Li, Xue Liang, Meiqi Zhang, Yuting He, Wandi Feng, Tong Luo, Yao Wang, Anlong Xu
2024, 14(6): 100972. doi: 10.1016/j.jpha.2024.100972
Abstract:

The stimulator of interferon genes (STING), an integral adaptor protein in the DNA-sensing pathway, plays a pivotal role in the innate immune response against infections. Additionally, it presents a valuable therapeutic target for infectious diseases and cancer. We observed that fangchinoline (Fan),...

Secondary metabolites of mulberry leaves exert anti-lung cancer activity through regulating the PD-L1/PD-1 signaling pathway
Guiqin Ye, Xin Sun, Jiuzhou Li, Yuanyuan Mai, Ruilan Gao, Jianbin Zhang
2024, 14(6): 100926. doi: 10.1016/j.jpha.2023.12.016
Abstract:

Lung cancer ranks the top of malignancies that cause cancer-related deaths worldwide. The leaves of Morus alba L are traditional Chinese medicine widely applied in respiratory diseases. Our previous work has demonstrated the anti-lung cancer effect of secondary metabolites of mulberry leaf, but thei...

Short communications
Establishment of microneurovascular units in alginate hydrogel microspheres to reveal the anti-hypoxic effect of salidroside
Shiyu Chen, Yuxuan Li, Yingrui Zhang, Hongren Yao, Tong Xu, Yi Zhang, Jin-Ming Lin, Xian-Li Meng
2024, 14(6): 100967. doi: 10.1016/j.jpha.2024.100967
Abstract:
Medcheck: A novel software for automated de-formulation of traditional Chinese medicine (TCM) prescriptions by liquid chromatography-mass spectrometry
Xiao-lan Li, Jian-qing Zhang, Yun Li, Xuan-jing Shen, Huan-ya Yang, Lin Yang, Meng Xu, Qi-rui Bi, Chang-liang Yao, De-an Guo
2024, 14(6): 100958. doi: 10.1016/j.jpha.2024.02.012
Abstract:
Corrigenda
Corrigendum to “Active components of Dengzhan Shengmai ameliorate cognitive impairment by facilitating hippocampal long-term potentiation via the NMDA receptor-mediated Ca2+/CaMKII pathway” [J. Pharm. Anal. 14 (2024) 435–438]
Congyu Ma, Ning Sheng, Jun Wu, Lulu Wang, Jiandong Jiang, Haibo Yu, Jinlan Zhang
2024, 14(6): 101025. doi: 10.1016/j.jpha.2024.101025
Abstract:
Corrigendum to “Nitrosamines crisis in pharmaceuticals - Insights on toxicological implications, root causes and risk assessment: A systematic review” [J. Pharm. Anal. 14 (2024) 100919]
Hemanth P. R. Vikram, Tegginamath Pramod Kumar, Gunjan Kumar, Narasimha M. Beeraka, Rajashree Deka, Sheik Mohammed Suhail, Sandeep Jat, Namitha Bannimath, Gayatiri Padmanabhan, Ravandur S. Chandan, Pramod Kumar, Bannimath Gurupadayya
2024, 14(6): 101033. doi: 10.1016/j.jpha.2024.101033
Abstract: