Journal of Pharmaceutical Analysis

Development of forced degradation and stability indicating studies of drugs-A review

Blessy Mn, Ruchi D. Patel, Prajesh N. Prajapati, Y.K. Agrawal

2014, (3): 159-165. doi: 10.1016/j.jpha.2013.09.003

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Forced degradation is a degradation of new drug substance and drug product at conditions more severe than accelerated conditions. It is required to demonstrate specificity of stability indicating methods and also provides an insight into degradation pathways and degradation products of the drug subs...

Direct detection and identification of active pharmaceutical ingredients in intact tablets by helium plasma ionization (HePI) mass spectrometry

Athula B. Attygalle, Freneil B. Jariwala, Julius Pavlov, Zhihua Yang, Jason A. Mahr, Mabel Oviedo

2014, (3): 166-172. doi: 10.1016/j.jpha.2013.09.010

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A simple modification converts an electrospray ion source to an ambient-pressure helium plasma ionization source without the need of additional expensive hardware. Peaks for active ingredients were observed in the spectra recorded from intact pharmaceutical tablets placed in this source. A flow of h...

Derringer desirability and kinetic plot LC-column comparison approach for MS-compatible lipopeptide analysis

Matthias D’Hondt, Frederick Verbeke, Sofie Stalmans, Bert Gevaert, Evelien Wynendaele, Bart De Spiegeleern

2014, (3): 173-183. doi: 10.1016/j.jpha.2013.09.001

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Lipopeptides are currently re-emerging as an interesting subgroup in the peptide research field, having historical applications as antibacterial and antifungal agents and new potential applications as antiviral, antitumor, immune-modulating and cell-penetrating compounds. However, due to their speci...

Combined collision-induced dissociation and photo-selected reaction monitoring mass spectrometry modes for simultaneous analysis of coagulation factors and estrogens

Quentin Enjalbert, Marion Girod, Jérémy Jeudy, Jordane Biarc, Romain Simon, Rodolphe Antoine, Philippe Dugourd, Jér?me Lemoine, Arnaud Salvador

2014, (3): 183-189. doi: 10.1016/j.jpha.2013.09.004

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Oral estrogens are directly associated with changes in plasma levels of coagulation proteins. Thus, the detection of any variation in protein concentrations due to estrogen contraceptives, by a simultaneous analysis of both coagulation proteins and estrogens, would be a very informative tool. In the...

Profiling the dynamics of abscisic acid and ABA-glucose ester after using the glucosyltransferase UGT71C5 to mediate abscisic acid homeostasis in Arabidopsis thaliana by HPLC-ESI-MS/MS

Dong-Mei Xiong, Zhen Liu, Han Chen, Jin-Tao Xue, Yi Yang, Cong Chen, Li-Ming Ye

2014, (3): 190-196. doi: 10.1016/j.jpha.2014.01.004

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The HPLC-MS/MS method was developed to profile the dynamics of abscisic acid (ABA) and ABA-glucose ester (ABA-GE) after cloning glycosyltransferase enzyme family gene AtUGT71C5 into Arabidopsis thaliana. By constructing over-expression lines (OE) and down-expression lines (DN), we acquired mutant st...

Enantiomeric characterization and structure elucidation of Otamixaban

Jian Shen, Jiping Yang, Winfried Heyse, Harald Schweitzer, Norbert Nagel, Doris Andert, Chengyue Zhu, Vincent Morrison, Gregory A. Nemeth, Teng-Man Chen, Zhicheng Zhao, Timothy A. Ayers, Yong-Mi Choi

2014, (3): 197-204. doi: 10.1016/j.jpha.2013.10.001

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Otamixaban is a potent (Ki ? 0.5 nM) fXa inhibitor currently in late-stage clinical develop-ment at Sanofi for the management of acute coronary syndrome. Being unproductive in obtaining a suitable crystal of Otamixaban, the required enantiomeric characterization has been accomplished using vibration...

Determination of mycophenolic acid in human plasma by ultra performance liquid chromatography tandem mass spectrometry

Vivek Upadhyay, Vikas Trivedi, Gaurang Shah, Manish Yadav, Pranav S. Shrivastav

2014, (3): 205-216. doi: 10.1016/j.jpha.2013.06.001

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A simple, sensitive and high throughput ultra performance liquid chromatography tandem mass spectrometry method has been developed for the determination of mycophenolic acid in human plasma. The method involved simple protein precipitation of MPA along with its deuterated analog as an internal stand...

Quality analysis of commercial samples of Ziziphi spinosae semen (suanzaoren) by means of chromatographic fingerprinting assisted by principal component analysis

Shuai Sun, Hailing Liu, Shunjun Xu, Yuzhen Yan, Peishan Xie

2014, (3): 217-222. doi: 10.1016/j.jpha.2014.01.003

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Due to the scarcity of resources of Ziziphi spinosae semen (ZSS), many inferior goods and even adulterants are generally found in medicine markets. To strengthen the quality control, HPLC fingerprint common pattern established in this paper showed three main bioactive compounds in one chromatogram s...

Application of analytical instruments in pharmaceutical analysis

2014, (3): 223-226.

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2014 Vol. 4, No. 3