Journal of Pharmaceutical Analysis

Charge-transfer interaction of drug quinidine with quinol, picric acid and DDQ:Spectroscopic characterization and biological activity studies towards understanding the drug-receptor mechanism

Hala H. Eldaroti, Suad A. Gadir, Moamen S. Refat, Abdel Majid A. Adam

2014, (2): 81-95.

Abstract(102) PDF(1)

Abstract:
Investigation of charge-transfer (CT) complexes of drugs has been recognized as an important phenomenon in understanding of the drug-receptor binding mechanism. Structural, thermal, morpholo-gical and biological behavior of CT complexes formed between drug quinidine (Qui) as a donor and quinol (QL),...

Quantitative and qualitative analysis of common peaks in chemical fingerprint of Yuanhu Zhitong tablet by HPLC-DAD-MS/MS

Dao-Quan Tang, Xiao-Xiao Zheng, Xu Chen, Dong-Zhi Yang, Qian Du

2014, (2): 96-106.

Abstract(161) PDF(0)

Abstract:
A quality control (QC) strategy for quantitative and qualitative analysis of “common peaks” in chemical fingerprint was proposed to analyze Yuanhu Zhitong tablet (YZT), using high performance liquid chromatography with diode array detector and tandem mass spectrometry (HPLC-DAD-MS/MS). The chromatog...

Selective separation, detection of zotepine and mass spectral characterization of degradants by LC-MS/MS/QTOF

M.V.N. Kumar Talluri, Naveen Reddy Kandimalla, Raju Bandu, Divya Chundi, Ramesh Marupaka, Ragampeta Srinivas

2014, (2): 107-116.

Abstract(97) PDF(2)

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A simple, precise, accurate stability-indicating gradient reversed-phase high-performance liquid chromatographic (RP-HPLC) method was developed for the quantitative determination of zotepine (ZTP) in bulk and pharmaceutical dosage forms in the presence of its degradation products (DPs). The method w...

A solid-phase extraction approach for the identification of pharmaceutical-sludge adsorption mechanisms

Laurence Berthod, Gary Roberts, Graham A. Mills

2014, (2): 117-124.

Abstract(109) PDF(0)

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It is important to understand the adsorption mechanism of chemicals and active pharmaceu-tical ingredients (API) on sewage sludge since wastewater treatment plants are the last barrier before the release of these compounds to the environment. Adsorption models were developed considering mostly hydro...

Reagent-free determination of amikacin content in amikacin sulfate injections by FTIR derivative spectroscopy in a continuous flow system

José F. Ovalles, Máximo Gallignani, María R. Brunetto, Rebeca A. Rondón, Carlos Ayala

2014, (2): 125-131.

Abstract(100) PDF(0)

Abstract:
The quantitative estimation of amikacin (AMK) in AMK sulfate injection samples is reported using FTIR-derivative spectrometric method in a continuous flow system. Fourier transform of mid-IR spectra were recorded without any sample pretreatment. A good linear calibration (r40.999, %RSDo 2.0) in the ...

Determination of a novel ACE inhibitor in the presence of alkaline and oxidative degradation products using smart spectrophotometric and chemometric methods

Maha Abdel-Monem Hegazy, Maya Shaaban Eissa, Osama Ibrahim Abd El-Sattar, Mohamed Mohamed Abd El-Kawy

2014, (2): 132-143.

Abstract(125) PDF(0)

Abstract:
Simple, accurate, sensitive and validated UV spectrophotometric and chemometric methods were developed for the determination of imidapril hydrochloride (IMD) in the presence of both its alkaline (AKN) and oxidative (OXI) degradation products and in its pharmaceutical formulation. Method A is the fou...

Improved simultaneous quantitation of candesartan and hydrochlorthiazide in human plasma by UPLC-MS/MS and its application in bioequivalence studies

Bhupinder Singh, Rama S. Lokhandae, Ashish Dwivedi, Sandeep Sharma, Naveen Dubey

2014, (2): 144-152.

Abstract(102) PDF(1)

Abstract:
A validated ultra-performance liquid chromatography mass spectrometric method (UPLC-MS/MS) was used for the simultaneous quantitation of candesartan (CN) and hydrochlorothiazide (HCT) in human plasma. The analysis was performed on UPLC-MS/MS system using turbo ion spray interface. Negative ions were...

Determination of gouty arthritis' biomarkers in human urine using reversed-phase high-performance liquid chromatography

Lei-Wen Xiang, Jing Li, Jin-Ming Lin, Hai-Fang Li

2014, (2): 153-158.

Abstract(141) PDF(0)

Abstract:
Creatinine, uric acid, hypoxanthine and xanthine are important diagnostic biomarkers in human urine for gouty arthritis or renal disease diacrisis. A simple method for simultaneous determination of these biomarkers in urine based on reversed-phase high-performance liquid chromatography (RP-HPLC) wit...

Application of analytical instruments in pharmaceutical analysis

2014, (2): 159-162.

Abstract(112) PDF(0)

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2014 Vol. 4, No. 2