Clarifying the active ingredients &amp; pharmacological mechanisms of traditional Chinese medicines via modern pharmaceutical analysis techniques

Huaxin Zhou; Fengwen Yang; Haoyun Bai; Yanni Lv; Cheng Wang; Rui Liu; Heshui Yu; Shengli Han; Zheng Li

doi:10.1016/j.jpha.2026.101611

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Huaxin Zhou, Fengwen Yang, Haoyun Bai, Yanni Lv, Cheng Wang, Rui Liu, Heshui Yu, Shengli Han, Zheng Li. Clarifying the active ingredients & pharmacological mechanisms of traditional Chinese medicines via modern pharmaceutical analysis techniques[J]. Journal of Pharmaceutical Analysis. doi: 10.1016/j.jpha.2026.101611

Citation:

Huaxin Zhou, Fengwen Yang, Haoyun Bai, Yanni Lv, Cheng Wang, Rui Liu, Heshui Yu, Shengli Han, Zheng Li. Clarifying the active ingredients & pharmacological mechanisms of traditional Chinese medicines via modern pharmaceutical analysis techniques[J]. Journal of Pharmaceutical Analysis. doi: 10.1016/j.jpha.2026.101611

Citation:

Huaxin Zhou, Fengwen Yang, Haoyun Bai, Yanni Lv, Cheng Wang, Rui Liu, Heshui Yu, Shengli Han, Zheng Li. Clarifying the active ingredients & pharmacological mechanisms of traditional Chinese medicines via modern pharmaceutical analysis techniques[J]. Journal of Pharmaceutical Analysis. doi: 10.1016/j.jpha.2026.101611

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Clarifying the active ingredients & pharmacological mechanisms of traditional Chinese medicines via modern pharmaceutical analysis techniques

doi: 10.1016/j.jpha.2026.101611

Huaxin Zhou^a,
Fengwen Yang^b,c,
Haoyun Bai^d,
Yanni Lv^d,
Cheng Wang^d,
Rui Liu^d,
Heshui Yu^a,b,c,
Shengli Han^{d
,
,},
Zheng Li^{a,b,c
,
,}

a. College of Pharmaceutical Engineering of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China;
b. State Key Laboratory of Chinese Medicine Modernization, Tianjin, 301617, China;
c. Tianjin Key Laboratory of Intelligent and Green Pharmaceuticals for Traditional Chinese Medicine, Tianjin, 301617, China;
d. School of Pharmacy, Xi’an Jiaotong University, Xi’an, 710061, China

Funds:

This work was financially supported by the National Key Research and Development Program of China (Grant No.: 2024YFC3506900), the Science and Technology Program of Tianjin, China (Grant No.: 25ZXZSSS00280) and the Special Project for Technological Innovation in New Productive Forces of Modern Chinese Medicines, China (Grant No.: 24ZXZKSY00010). The author would like to thank Prof. Boli Zhang (Academician of the Chinese Academy of Engineering, Tianjin University of Traditional Chinese Medicine) for proposing the idea of this paper and for his critical suggestions and meticulous guidance throughout the writing process.

Received Date: Jan. 27, 2026
Accepted Date: Mar. 23, 2026
Rev Recd Date: Mar. 22, 2026
Available Online: Mar. 25, 2026

Abstract

Abstract

As a widely practiced clinical medical system, traditional Chinese medicine (TCM) possesses a theoretical and practical foundation accumulated over thousands of years. With growing global interest in natural therapies, TCM is currently facing a historic opportunity for globalization. However, its widespread international acceptance still faces significant challenges due to the lack of standardization, variability in herbal quality, incomplete understanding of its mechanisms of action, and gaps in meeting international regulatory requirements for medicines. With the rapid development of analytical tools and methods, advances in artificial intelligence (AI), and continuous progress in pharmaceutical sciences, comprehensive high-throughput pharmacological research, quality control, and the establishment of regulatory approaches for the complex system of TCM are gradually becoming feasible. This study systematically expounds on the current applications and challenges of modern analytical methods in TCM formulation research from the perspective of analytical technology, covering key aspects including the efficacious components of TCM, multi-component analysis of herbal medicines, application models of modern analytical techniques, correlation analysis between the bioactive constituents of TCM formulations and their pharmacological mechanisms, and the establishment of quality control methods based on efficacy-related substances.
- Traditional Chinese medicine,
- Active ingredients,
- Pharmacological mechanisms,
- Pharmaceutical analysis techniques,
- Multi-component analysis

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References(160)

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