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Karolina Knap, Konrad Kwiecień, Jonasz Czajkowski, Rafał Szostecki, Daria Niewolik, Katarzyna Jaszcz, Peter Olinga, Katarzyna Reczyńska-Kolman, Elżbieta Pamuła. Drug delivery system of curcumin to the lungs based on poly(3-alloxyloxy-1,2-propylene succinate)-sebacic acid copolymers[J]. Journal of Pharmaceutical Analysis. doi: 10.1016/j.jpha.2025.101434
Citation: Karolina Knap, Konrad Kwiecień, Jonasz Czajkowski, Rafał Szostecki, Daria Niewolik, Katarzyna Jaszcz, Peter Olinga, Katarzyna Reczyńska-Kolman, Elżbieta Pamuła. Drug delivery system of curcumin to the lungs based on poly(3-alloxyloxy-1,2-propylene succinate)-sebacic acid copolymers[J]. Journal of Pharmaceutical Analysis. doi: 10.1016/j.jpha.2025.101434

Drug delivery system of curcumin to the lungs based on poly(3-alloxyloxy-1,2-propylene succinate)-sebacic acid copolymers

doi: 10.1016/j.jpha.2025.101434
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This study was supported by the National Science Centre, Poland (Project No.: 2019/35/B/ST5/01103) and the Program “Excellence Initiative – Research University” for the AGH University of Krakow, Poland.The authors would like to thank Prof. Kinga Pielichowska from the Department of Glass Technology and Amorphous Coatings at the Faculty of Materials Science and Ceramics, AGH University of Krakow, Poland for the help with differential scanning calorimetry (DSC) studies and Dr. Agnieszka Wojteczko from the Laboratory of Electron Microscopy at the Faculty of Materials Science and Ceramics, AGH University of Krakow, Poland for the help with scanning electron microscopy (SEM) observations. Graphical abstract was drawn by using BioRender.com.

  • Received Date: Feb. 25, 2025
  • Accepted Date: Aug. 09, 2025
  • Rev Recd Date: Jul. 03, 2025
  • Available Online: Aug. 15, 2025
  • Polyanhydrides are attractive materials for drug delivery matrices as a result of their cytocompatibility and fast degradation rate. Here, we synthesized and characterized copolymers of poly(3-allyloxy-1,2-propylene succinate) (PSAGE) and sebacic acid (SBA). The successful polymerization was confirmed by proton nuclear magnetic resonance (1H NMR) and Fourier transform infrared (FTIR) spectroscopy analyses. The material with 40% PSAGE (PSAGE-SBA60) was more hydrophilic than the material with 20% PSAGE (PSAGE-SBA80) (water contact angle 82.2 ± 11.6° vs. 98.6 ± 8.9°, respectively). PSAGE-SBA60 also had a lower molecular weight than PSAGE-SBA80 (Mn = 6,400 Da vs. 9,800 Da). Both polyanhydrides were used to encapsulate curcumin (CUR) as a potential anti-inflammatory, antimicrobial and anticancer agent. The unloaded microparticles (MPs) and CUR-loaded MPs were produced using the emulsification/solvent evaporation method. The CUR was uniformly distributed within the MPs, as confirmed by fluorescence microscopy. All MPs had a geometric diameter < 5 μm and their surface charge was negative. MPs_PSAGE-SBA80 + CUR had the best aerodynamic properties, as shown by laser diffraction measurements and flowability parameters, i.e. Carr index and Hausner ratio. The MPs obtained from PSAGE-SBA60 degraded faster than those of PSAGE-SBA80. All MPs were noncytotoxic at a concentration of up to 100 μg/ml in the in vitro model (BEAS-2B lung epithelial cells) and ex vivo precision-cut tissue slices (PCTSs) rat model. The developed MPs are promising CUR carriers for pulmonary delivery in a dry powder formulation.
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