Gold nanorod-based engineered nanogels for cascade-amplifying photothermo-enzymatic synergistic therapy

Ling Ding; Xiaoshan Wang; Qing Wu; Xia Wang; Qigang Wang

doi:10.1016/j.jpha.2024.101139

Volume 14 Issue 12

Dec. 2024

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Ling Ding, Xiaoshan Wang, Qing Wu, Xia Wang, Qigang Wang. Gold nanorod-based engineered nanogels for cascade-amplifying photothermo-enzymatic synergistic therapy[J]. Journal of Pharmaceutical Analysis, 2024, 14(12): 101139. doi: 10.1016/j.jpha.2024.101139

Citation:

Ling Ding, Xiaoshan Wang, Qing Wu, Xia Wang, Qigang Wang. Gold nanorod-based engineered nanogels for cascade-amplifying photothermo-enzymatic synergistic therapy[J]. Journal of Pharmaceutical Analysis, 2024, 14(12): 101139. doi: 10.1016/j.jpha.2024.101139

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Gold nanorod-based engineered nanogels for cascade-amplifying photothermo-enzymatic synergistic therapy

doi: 10.1016/j.jpha.2024.101139

Ling Ding^a,
Xiaoshan Wang^a,
Qing Wu^{b
,
,},
Xia Wang^{a
,
,},
Qigang Wang^{a,b
,
,}

a. School of Chemical Science and Engineering, Tongji University, Shanghai, 200092, China;
b. Shanghai Key Laboratory of Anesthesiology and Brain Functional Modulation, Clinical Research Center for Anesthesiology and Perioperative Medicine, Translational Research Institute of Brain and Brain-Like Intelligence, Shanghai Fourth People's Hospital, School of Medicine, Tongji University, Shanghai, 200434, China

Funds:

This work was financially supported by the National Key Research and Development Program of China (Grant No.: 2022YFC2403200), the National Natural Science Foundation of China (Grant No.: 52173289), and the National Science Fund for Distinguished Young Scholars, China (Grant No.: 52125305).

Received Date: Mar. 04, 2024
Accepted Date: Oct. 29, 2024
Rev Recd Date: Oct. 10, 2024
Publish Date: Nov. 01, 2024

Abstract

Abstract

Reactive oxygen species (ROS)-mediated anticancer modalities, which disturb the redox balance of cancer cells through multi-pathway simulations, hold great promise for effective cancer management. Among these, cooperative physical and biochemical activation strategies have attracted increasing attention because of their spatiotemporal controllability, low toxicity, and high therapeutic efficacy. Herein, we demonstrate a nanogel complex as a multilevel ROS-producing system by integrating chloroperoxidase (CPO) into gold nanorod (AuNR)-based nanogels (ANGs) for cascade-amplifying photothermal-enzymatic synergistic tumor therapy. Benefiting from photothermal-induced hyperthermia upon near-infrared (NIR) laser exposure, the exogenous ROS (including H₂O₂) were boosted by the AuNR nanogel owing to the intercellular stress response. This ultimately promoted the efficient enzyme-catalyzed reaction of loaded CPO combined with the rich endogenous H₂O₂ in tumor cells to significantly elevate intracellular ROS levels above the threshold for improved therapeutic outcomes. Both in vitro and in vivo studies have verified the cascade-amplifying ROS-mediated antitumor effects, providing feasible multimodal synergistic tactics for tumor treatment.
- Nanogels,
- Photothermal-enzymatic synergistic therapy,
- ROS-Based nanodynamic therapies

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References(40)

References

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