2012 Vol. 2, No. 4

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2012, 02(4): 后插1-后插2,封3.
Abstract(84) PDF(6)
Abstract:
Second-order calibration applied to quantification of two active components of Schisandra chinensis in complex matrix
Xiao-Hua Zhang, Hai-Long Wu, Jian-Yao Wang, Yao Chen, Yong-Jie Yu, Chong-Chong Nie, Chao Kang, De-Zhu Tu, Ru-Qin Yu
2012, 02(4): 241-248.
Abstract(90) PDF(6)
Abstract:
The effectiveness of traditional Chinese medicine (TCM) against various diseases urges more low cost,speed and sensitive analytical methods for investigating the phamacology of TCM and providing a theoretical basis for clinical use.The potential of second-order calibration method was validated for t...
Quantification of sibutramine and its two metabolites in human plasma by LC-ESI-MS/MS and its application in a bioequivalence study
Venkata Suresh Ponnuru, B.R.Challa, RamaRao Nadendla
2012, 02(4): 249-257. doi: 10.1016/j.jpha.2012.02.010
Abstract(103) HTML Full Text PDF(6)
Abstract:
Obesity can be considered as a chronic illness of epidemic proportion and its incidents have increased exponentially in recent years.The use of anti-obesity drugs such as sibutramine is somewhat helpful.There is a need to quantify such drugs in biological samples,which is generally quite difficult.I...
Preparative isolation and purification of 12,13-dihydroxyeuparin from Radix Eupatorii Chinensis by high-speed counter-current chromatography
Mei Yang, Xin-Jun Xu, Chun-Yan Xie, Jie-Yun Huang, Zhi-Sheng Xie, De-Po Yang
2012, 02(4): 258-263. doi: 10.1016/j.jpha.2012.03.004
Abstract(97) HTML Full Text PDF(7)
Abstract:
An efficient method for the isolation and purification of 12,13-dihydroxyeuparin from Radix Eupatorii Chinensis by high speed counter-current chromatography (HSCCC) was established in this paper.The ether extracts of Radix Eupatorii Chinensis were purified by HSCCC with a solvent system of hexyl hyd...
LC-UV and LC-MS evaluation of stress degradation behavior of desvenlafaxine
Shubhangi M.Pawar, Laxman D.Khatal, Satish Y.Gabhe, Sunil R.Dhaneshwar
2012, 02(4): 264-271.
Abstract(114) PDF(8)
Abstract:
The objective of current study was to develop a validated specific stability indicating reversed-phase liquid chromatographic method for the quantitative determination of desvenlafaxine in bulk sample and pharmaceutical dosage form in the presence of degradation products.Forced degradation studies w...
A validated stability-indicating LC method for the separation of enantiomer and potential impurities of Linezolid using polar organic mode
T.Satyanarayana Raju, O.Vishweshwari Kutty, V.Ganesh, P.Yadagiri Swamy
2012, 02(4): 272-278.
Abstract(95) PDF(4)
Abstract:
Although a number of methods are available for evaluating Linezolid and its possible impurities,a common method for separation if its potential impurities,degradants and enantiomer in a single method with good efficiency remain unavailable.With the objective of developing an advanced method with sho...
Two spectrophotometric methods for simultaneous determination of some antihyperlipidemic drugs
Nada S.Abdelwahab, Badr A.El-Zeiny, Salwa I.Tohamy
2012, 02(4): 279-284. doi: 10.1016/j.jpha.2012.02.002
Abstract(121) HTML Full Text PDF(4)
Abstract:
Two simple,accurate,precise and economic spectrophotometric methods have been developed for simultaneous determination of Atorvastatin calcium (ATR) and Ezetimibe (EZ) in their bulk powder and pharmaceutical dosage form.Method (Ⅰ) is based on dual wavelength analysis while method (Ⅱ) is the mean cen...
Synchronized separation of atorvastatin-an antihyperlipidemic drug with antihypertensive, antidiabetic,antithrombotic drugs by RP-LC for determination in combined formulations
M.V.N.Kumar Talluri, Anitha Kalyankar, Srinivas Ragampeta
2012, 02(4): 285-292. doi: 10.1016/j.jpha.2012.02.006
Abstract(133) HTML Full Text PDF(4)
Abstract:
A new rapid and sensitive high performance liquid chromatography (HPLC) method has been developed for the simultaneous determination of atorvastatin-an antihyperlipidemic drug along with most commonly prescribed drugs (antihyperlipidemic,antihypertensive,antidiabetic,antithrombotic) in bulk and mark...
Cytotoxicity and cellular imaging of quantum dots protected by polyelectrolyte
Hai-Yan Hu, Xing-Ru Dou, Zong-Lin Jiang, Jian-Hua Tang, Lian Xie, Hong-Ping Xie
2012, 02(4): 293-297. doi: 10.1016/j.jpha.2012.02.003
Abstract(116) HTML Full Text PDF(4)
Abstract:
The nanocomposites of poly-diallyldimethylammonium chloride (PDADMAC) and CdTe quantum dots (QDs) (i.e.QDs-PDADMAC nanocomposites) have been prepared based on electrostatic interaction and their fluorescence stability in aqueous solution has been investigated. MTT method (3-(4, 5-dimethylthiazol-2-y...
Stability-indicating liquid chromatographic method for the determination of Letrozole in pharmaceutical formulations
M.Mathrusri Annapurna, Chitaranjan Mohapatro, A.Narendra
2012, 02(4): 298-305. doi: 10.1016/j.jpha.2012.01.010
Abstract(104) HTML Full Text PDF(7)
Abstract:
A stability-indicating high-performance liquid chromatographic method was developed and validated for the determination of Letrozole in tablet dosage forms.Reversed-phase chromatography was performed on Shimadzu Model LC-Class-Vp with Lichrocart/Lichrosphere 100 C-18 (250 mm × 4.6 mm,5 μm particle s...
Azeotropic mixture used for development and validation of Lornoxicam in bulk and its tablet dosage form by spectrophotometric method
Prajesh Prajapati, Vipul Vaghela, Deepak Rawtani, Harshad Patel, Jasmin Kubavat, Dharmendra Baraiya
2012, 02(4): 306-309. doi: 10.1016/j.jpha.2012.02.004
Abstract(188) HTML Full Text PDF(4)
Abstract:
A novel,safe,economic and sensitive method of spectrophotometric estimation has been developed using Azeoptropic mixture (water∶methanol:60∶40,v/v) for the quantitative determination of Lornoxicam,a practically water-insoluble drug.Hence,Lornoxicam stock solution was prepared in Azeoptropic mixture....
Rapid analysis of piperazine ferulate tablets by optic-fiber sensing technology and the similarity of ultraviolet spectra
Li Li, Chun-Ling Zhang, Lu Jin, Cui-Juan Feng
2012, 02(4): 310-313.
Abstract(76) PDF(4)
Abstract:
A rapid analysis method of piperazine ferulate tablets by optic-fiber sensing technology with UV-vis absorption spectrum was established.Qualitative and quantitative data were obtained and compared by maximum and minimum wavelength,absorbance and contrast spectra.Similarity method was used to identi...
Determination of genotoxic alkyl methane sulfonates and alkyl paratoluene sulfonates in lamivudine using hyphenated techniques
N.V.V.S.S.Raman, A.V.S.S.Prasad, K.Ratnakar Reddy, K.Ramakrishna
2012, 02(4): 314-318. doi: 10.1016/j.jpha.2012.03.003
Abstract(121) HTML Full Text PDF(4)
Abstract:
Two highly sensitive methods for the determination of genotoxic alkyl methane sulfonates (AMSs) and alkyl paratoluene sulfonates (APTSs) in lamivudine using hyphenated techniques have been presented.AMSs were determined by GC-MS method using GSBPINOWAX (30 m × 0.25 mm × 0.25 μm) column.Temperature p...

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