Discovery of Mitochondrial Modulators Using Target-Aggregated Machine Learning

Lizhuo Wang; Peng Yang; Sirui Wu; Fanding Xu; Wu Su; Le Shi; Hui Guo; Li Cui; Jiankang Liu; Zhiwei Yang; Jiangang Long

doi:10.1016/j.jpha.2026.101579

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Lizhuo Wang, Peng Yang, Sirui Wu, Fanding Xu, Wu Su, Le Shi, Hui Guo, Li Cui, Jiankang Liu, Zhiwei Yang, Jiangang Long. Discovery of Mitochondrial Modulators Using Target-Aggregated Machine Learning[J]. Journal of Pharmaceutical Analysis. doi: 10.1016/j.jpha.2026.101579

Citation:

Lizhuo Wang, Peng Yang, Sirui Wu, Fanding Xu, Wu Su, Le Shi, Hui Guo, Li Cui, Jiankang Liu, Zhiwei Yang, Jiangang Long. Discovery of Mitochondrial Modulators Using Target-Aggregated Machine Learning[J]. Journal of Pharmaceutical Analysis. doi: 10.1016/j.jpha.2026.101579

Citation:

Lizhuo Wang, Peng Yang, Sirui Wu, Fanding Xu, Wu Su, Le Shi, Hui Guo, Li Cui, Jiankang Liu, Zhiwei Yang, Jiangang Long. Discovery of Mitochondrial Modulators Using Target-Aggregated Machine Learning[J]. Journal of Pharmaceutical Analysis. doi: 10.1016/j.jpha.2026.101579

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Discovery of Mitochondrial Modulators Using Target-Aggregated Machine Learning

doi: 10.1016/j.jpha.2026.101579

Lizhuo Wang^a,
Peng Yang^a,
Sirui Wu^b,
Fanding Xu^a,
Wu Su^a,
Le Shi^a,
Hui Guo^c,
Li Cui^a,
Jiankang Liu^a,d,
Zhiwei Yang^{e
,
,},
Jiangang Long^{a
,
,}

a. Center for Mitochondrial Biology and Medicine, The Key Laboratory of Biomedical Information Engineering of the Ministry of Education, School of Life Science and Technology, Xi’an Jiaotong University, Xi’an, 710049, China;
b. China Mobile Communications Group Shaanxi Co., Ltd., Xi'an, 710049, China;
c. Department of Endocrinology, First Affiliated Hospital of Medical College, Xi'an Jiaotong University, Xi'an, 710049, China;
d. School of Health and Life Sciences, University of Health and Rehabilitation Sciences, Qingdao, Shandong, 266071, China;
e. MOE Key Laboratory for Nonequilibrium Synthesis and Modulation of Condensed Matter, School of Physics, Xi’an Jiaotong University, Xi’an, 710049, China

Funds:

This study was supported by the Key Research and Development Plan Project of Shaanxi Province, China (Project No.: 2024SF-ZDCYL-03-24, China), the Frontier Exploration Research Fund of Xi'an Jiaotong University - China Mobile Communications Group Co.,Ltd. Joint Institute (Grant No.: XJTU-CMCC-QY202508005, China), and the China National Foreign Experts Project (Project No.: G2022170026L, China). The authors would like to thank Dr. Minxia Zhu (Xizang Minzu University, Xianyang, Shaanxi, China) and Dr. Xudong Wang (Xi’an Jiaotong University, Xi’an, China) for their assistance in providing experimental equipment or materials. We also thank the technical assistance from Haomiao Liu, Danyu Cheng, Mengyao Lei, Hua Li, Yifang Wang, and Dr. Yunhua Peng (Xi’an Jiaotong University, Xi’an, China).

Received Date: Aug. 24, 2025
Accepted Date: Feb. 07, 2026
Rev Recd Date: Feb. 05, 2026
Available Online: Feb. 10, 2026

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References(5)

References

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