The anti-hyperuricemia potential of bioactive natural products and extracts derived from traditional Chinese medicines: A review and perspective

Yaolei Li; Zhijian Lin; Hongyu Jin; Feng Wei; Shuangcheng Ma; Bing Zhang

doi:10.1016/j.jpha.2024.101183

Volume 15 Issue 7

Jul. 2025

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Yaolei Li, Zhijian Lin, Hongyu Jin, Feng Wei, Shuangcheng Ma, Bing Zhang. The anti-hyperuricemia potential of bioactive natural products and extracts derived from traditional Chinese medicines: A review and perspective[J]. Journal of Pharmaceutical Analysis, 2025, 15(7): 101183. doi: 10.1016/j.jpha.2024.101183

Citation:

Yaolei Li, Zhijian Lin, Hongyu Jin, Feng Wei, Shuangcheng Ma, Bing Zhang. The anti-hyperuricemia potential of bioactive natural products and extracts derived from traditional Chinese medicines: A review and perspective[J]. Journal of Pharmaceutical Analysis, 2025, 15(7): 101183. doi: 10.1016/j.jpha.2024.101183

Citation:

Yaolei Li, Zhijian Lin, Hongyu Jin, Feng Wei, Shuangcheng Ma, Bing Zhang. The anti-hyperuricemia potential of bioactive natural products and extracts derived from traditional Chinese medicines: A review and perspective[J]. Journal of Pharmaceutical Analysis, 2025, 15(7): 101183. doi: 10.1016/j.jpha.2024.101183

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The anti-hyperuricemia potential of bioactive natural products and extracts derived from traditional Chinese medicines: A review and perspective

doi: 10.1016/j.jpha.2024.101183

a. School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing, 102488, China;
b. National Institutes for Food and Drug Control, Beijing, 102629, China

Funds:

This work was supported by the National Natural Science Foundation of China (Grant No: U20A20406).

Received Date: Aug. 18, 2024
Accepted Date: Dec. 30, 2024
Rev Recd Date: Dec. 27, 2024
Publish Date: Jan. 03, 2025

Abstract

Abstract

Hyperuricemia (HUA) and gout became typical metabolic disorders characterized by multiple pathogenic factors. Their incidence increased annually, affecting younger populations. Given that uric acid (UA) and inflammation were the primary disease mechanisms, the search for effective and low-side-effect UA-lowering and anti-inflammatory drugs became a pressing scientific priority. Traditional Chinese medicine (TCM) encompassed a rich array of theoretical and practical experience, along with a diverse range of chemical substances, making herbs or their components potential sources for therapeutic drugs. Despite the significant role that modern herbal medicines played in treating HUA and gout, the existing research literature remained fragmented, lacking comprehensive and systematic reviews. In this review, we focused on the regulation of UA and summarized the discovery of UA-lowering pharmacodynamic components or ingredients derived from herbs and formulas, as well as their multi-targeted mechanisms of action. Emphasizing this focus, we proposed that, compared to acute inflammation, low-grade inflammation may play a relatively “unnoticed” role in the disease process. In contrast to Western medicine, we discussed the risks and benefits of herbal medicines and their ingredients for treatment, drawing from theoretical insights and clinical practice. This review offered comprehensive perspectives on the research into anti-HUA and gout treatments using herbal medicines and their natural products. Additionally, it provided a forward-looking view on natural product discovery, the exploration of therapeutic strategies, and new drug research in this field.
- Hyperuricemia,
- Gout,
- Uric acid,
- Traditional Chinese medicine,
- Natural products,
- Inflammation

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References(179)

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