Volume 10 Issue 1
Feb.  2020
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Ana-Maria Totea, Juan Sabin, Irina Dorin, Karl Hemming, Peter R. Laity, Barbara R. Conway, Laura Waters, Kofi Asare-Addo. Thermodynamics of clay-drug complex dispersions: Isothermal titration calorimetry and high-performance liquid chromatography[J]. Journal of Pharmaceutical Analysis, 2020, 10(1): 78-85.
Citation: Ana-Maria Totea, Juan Sabin, Irina Dorin, Karl Hemming, Peter R. Laity, Barbara R. Conway, Laura Waters, Kofi Asare-Addo. Thermodynamics of clay-drug complex dispersions: Isothermal titration calorimetry and high-performance liquid chromatography[J]. Journal of Pharmaceutical Analysis, 2020, 10(1): 78-85.

Thermodynamics of clay-drug complex dispersions: Isothermal titration calorimetry and high-performance liquid chromatography

  • Publish Date: Feb. 15, 2020
  • An understanding of the thermodynamics of the complexation process utilized in sustaining drug release in clay matrices is of great importance. Several characterisation techniques as well as isothermal calo-rimetry were utilized in investigating the adsorption process of a model cationic drug (diltiazem hy-drochloride, DIL) onto a pharmaceutical clay system (magnesium aluminium silicate, MAS). X-ray powder diffraction (XRPD), attenuated total reflectance Fourier transform infrared spectroscopy (ATR-FTIR) and optical microscopy confirmed the successful formation of the DIL-MAS complexes. Drug quantification from the complexes demonstrated variable behaviour in the differing media used with DIL degrading to desacetyl diltiazem hydrochloride (DC-DIL) in the 2 M HCl media. Here also, the authors report for the first time two binding processes that occurred for DIL and MAS. A competitor binding model was thus proposed and the thermodynamics obtained suggested their binding processes to be enthalpy driven and entropically unfavourable. This information is of great importance for a formulator as care and consideration should be given with appropriate media selection as well as the nature of binding in complexes.
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