Volume 8 Issue 5
Oct.  2018
Turn off MathJax
Article Contents
Selim Demir, Ibrahim Turan, Rezzan Aliyazicioglu, Serap Ozer Yaman, Yuksel Aliyazicioglu. Primula vulgaris extract induces cell cycle arrest and apoptosis in human cervix cancer cells[J]. Journal of Pharmaceutical Analysis, 2018, 8(5): 307-311.
Citation: Selim Demir, Ibrahim Turan, Rezzan Aliyazicioglu, Serap Ozer Yaman, Yuksel Aliyazicioglu. Primula vulgaris extract induces cell cycle arrest and apoptosis in human cervix cancer cells[J]. Journal of Pharmaceutical Analysis, 2018, 8(5): 307-311.

Primula vulgaris extract induces cell cycle arrest and apoptosis in human cervix cancer cells

  • Publish Date: Oct. 10, 2018
  • Primula vulgaris belongs to the genus Primula, members of which are frequently used in folk medicine. Various studies have investigated the cytotoxic effect of different Primula species, but there have been limited studies on the cytotoxic effect of P. vulgaris. The aim of this study was to investigate the cytotoxic effects, and possible mechanisms involved, of P. vulgaris flower extract on human cervical cancer (HeLa) cells. The cytotoxic effect of the extract on HeLa cells was revealed using the MTT assay. Mechanisms involved in the extract's cytotoxic effect were then investigated in terms of apoptosis, mitochondrial membrane potential, and the cell cycle, using fluorometric methods. P. vulgaris flower extract exhibited selective cytotoxic effects against HeLa cells by arresting their cell cycle at the S phase, and inducing the number of apoptotic cells compared to normal fibroblast cells by reducing mitochondrial membrane potential in a concentration-dependent manner. This is the first study to reveal the antiproliferative effect of P. vulgaris flower extract. Further studies are now needed to identify the cytotoxic molecules in the extract and their mechanisms.
  • loading
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Article Metrics

    Article views (213) PDF downloads(1) Cited by()
    Proportional views
    Related

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return