Volume 8 Issue 2
Apr.  2018
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Article Navigation >  Journal of Pharmaceutical Analysis  > 2018  >  8(2): 103-108
Luciana F.A. Romani, Maria I. Yoshida, Elionai C.L. Gomes, Renes R. Machado, Felipe F. Rodrigues, Márcio M. Coelho, Marcelo A. Oliveira, Maria B. Freitas-Marques, Rosane A.S. San Gil, Wagner N. Mussel. Physicochemical characterization, the Hirshfeld surface, and biological evaluation of two meloxicam compounding pharmacy samples[J]. Journal of Pharmaceutical Analysis, 2018, 8(2): 103-108.
Citation: Luciana F.A. Romani, Maria I. Yoshida, Elionai C.L. Gomes, Renes R. Machado, Felipe F. Rodrigues, Márcio M. Coelho, Marcelo A. Oliveira, Maria B. Freitas-Marques, Rosane A.S. San Gil, Wagner N. Mussel. Physicochemical characterization, the Hirshfeld surface, and biological evaluation of two meloxicam compounding pharmacy samples[J]. Journal of Pharmaceutical Analysis, 2018, 8(2): 103-108.
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Physicochemical characterization, the Hirshfeld surface, and biological evaluation of two meloxicam compounding pharmacy samples

  • Department of Chemistry, Institute of Exact Sciences, Federal University of Minas Gerais, Av. Ant?nio Carlos 6627, Belo Horizonte, MG, Brazil

  • Department of Pharmaceutical Products, Faculty of Pharmacy, Federal University of Minas Gerais, Av. Ant?nio Carlos 6627, Belo Horizonte, MG, Brazil

  • Health Science Department, Federal University of Espírito Santo, Campus S?o Mateus, ES, Brazil

  • Institute of Chemistry, Federal University of Rio de Janeiro, Campus Fund?o, RJ, Brazil

  • Publish Date: Apr. 10, 2018
    Abstract
  • Meloxicam (MLX) is an anti-inflammatory drug susceptible to variations and crystalline transitions. In compounding pharmacies, the complete crystallographic evaluation of the raw material is not a routine procedure. We performed a complete crystallographic characterization of aleatory raw MLX samples from compounding pharmacies. X-ray diffraction indicated the presence of two crystalline forms in one sample. DSC experiments suggested that crystallization, or a crystal transition, occurred differently be-tween samples. The FTIR and 1H NMR spectra showed characteristic assignments. 13C solid-state NMR spectroscopy indicated the presence of more than one phase in a sample from pharmacy B. The Hirshfeld surface analysis, with electrostatic potential projection, allowed complete assignment of the UV spectra in ethanol solution. The polymorph I of meloxicam was more active than polymorph Ⅲ in an experi-mental model of acute inflammation in mice. Our results highlighted the need for complete crystal-lographic characterization and the separation of freely used raw materials in compounding pharmacies, as a routine procedure, to ensure the desired dose/effect.
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    1. de Freitas-Marques, M.B., Araújo, N.R.S., Rosa Júnior, A.A. et al. Antiviral drugs preformulation: thermal energy effects by multilayer perceptron network approach and Hirshfeld surface properties. Journal of Thermal Analysis and Calorimetry, 2024. doi:10.1007/s10973-024-13275-5
    2. Cavalcante, C.D.Q.O., Garcia, E., da Mota, T.H.A. et al. Comparative investigation of Cu(II) complexes with dithiocarbazate: Structural design, theoretical calculation, and in vitro antitumor activity. Journal of Inorganic Biochemistry, 2022. doi:10.1016/j.jinorgbio.2022.112015
    3. Tana, I.D.T., Saúde-Guimarães, D.A., Caldeira, T.G. et al. Biopharmaceutics studies applied to goyazensolide: a drug candidate from Lychnophora species. Journal of Pharmacy and Pharmacology, 2022, 74(8): 1140-1151. doi:10.1093/jpp/rgac020
    4. Samra, M.M., Sadia, A., Azam, M. et al. Synthesis, Spectroscopic and Biological Investigation of a New Ca(II) Complex of Meloxicam as Potential COX-2 Inhibitor. Arabian Journal for Science and Engineering, 2022, 47(6): 7105-7122. doi:10.1007/s13369-021-06521-7
    5. Antiorio, A.T.F.B., Alemán-Laporte, J., Zanatto, D.A. et al. Mouse Behavior in the Open-field Test after Meloxicam Administration. Journal of the American Association for Laboratory Animal Science, 2022, 61(3): 270-274. doi:10.30802/AALAS-JAALAS-21-000046
    6. Brokešová, J., Slámová, M., Zámostný, P. et al. Mechanistic study of dissolution enhancement by interactive mixtures of chitosan with meloxicam as model. European Journal of Pharmaceutical Sciences, 2022. doi:10.1016/j.ejps.2021.106087
    7. Antiorio, A.T.F.B., Alemán-Laporte, J., Garcia-Gomes, M.S.A. et al. Assessment of general activity and anxiety-like behavior in mice following tramadol and meloxicam administration for managing immediate post-operative pain. Biological Models Research and Technology Journal, 2022, 2(1): e00182021. doi:10.4322/2675-9225.00182021
    8. Silva, C.R.G., Fialho, S.L., Barbosa, J. et al. Compatibility by a Nonisothermal Kinetic Study of Azathioprine Associated with Usual Excipients in the Product Quality Review Process. Journal of the Brazilian Chemical Society, 2021, 32(3): 638-651. doi:10.21577/0103-5053.20200218
    9. Gera, T., Nagy, E., Smausz, T. et al. Application of pulsed laser ablation (PLA) for the size reduction of non-steroidal anti-inflammatory drugs (NSAIDs). Scientific Reports, 2020, 10(1): 15806. doi:10.1038/s41598-020-72865-z
    10. Unsalan, O., Arı, H., Altunayar-Unsalan, C. et al. FTIR, Raman and DFT studies on 2-[4-(4-ethylbenzamido)phenyl]benzothiazole and 2-[4-(4-nitrobenzamido)phenyl]benzothiazole supported by differential scanning calorimetry. Journal of Molecular Structure, 2020. doi:10.1016/j.molstruc.2020.128454
    11. Castro, G.T., Filippa, M.A., Sancho, M.I. et al. Solvent effect on the solubility and absorption spectra of meloxicam: experimental and theoretical calculations. Physics and Chemistry of Liquids, 2020, 58(3): 337-348. doi:10.1080/00319104.2019.1594224
    12. Bolourchian, N., Nili, M., Foroutan, S.M. et al. The use of cooling and anti-solvent precipitation technique to tailor dissolution and physicochemical properties of meloxicam for better performance. Journal of Drug Delivery Science and Technology, 2020. doi:10.1016/j.jddst.2019.101485
    13. Demir, Y., Duran, H.E., Durmaz, L. et al. The Influence of Some Nonsteroidal Anti-inflammatory Drugs on Metabolic Enzymes of Aldose Reductase, Sorbitol Dehydrogenase, and α-Glycosidase: a Perspective for Metabolic Disorders. Applied Biochemistry and Biotechnology, 2020, 190(2): 437-447. doi:10.1007/s12010-019-03099-7
    14. Rusu, A., Ciurba, A., Bîrsan, M. et al. Compatibility study of four binary combinations of active ingredients for dermal film forming systems. Farmacia, 2020, 68(5): 800-811. doi:10.31925/farmacia.2020.5.5
    15. de Freitas Marques, M.B., de Araujo, B.C.R., de Cassia de Oliveira Sebastião, R. et al. Kinetics study and Hirshfeld surface analysis for atorvastatin calcium trihydrate and furosemide system. Thermochimica Acta, 2019. doi:10.1016/j.tca.2019.178408
    16. Rusu, A., Antonoaea, P., Ciurba, A. et al. Development of a rapid capillary zone electrophoresis method to quantify levofloxacin and meloxicam from transdermal therapeutic systems. Studia Universitatis Babes-Bolyai Chemia, 2019, 64(1): 219-231. doi:10.24193/subbchem.2019.1.18

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