Gema M. Durán, Tomás E. Benavidez, Ana M. Contento, Angel Ríos, Carlos D. García. Analysis of penicillamine using Cu-modified graphene quantum dots synthesized from uric acid as single precursor[J]. Journal of Pharmaceutical Analysis, 2017, 7(5): 324-331.
Citation:
Gema M. Durán, Tomás E. Benavidez, Ana M. Contento, Angel Ríos, Carlos D. García. Analysis of penicillamine using Cu-modified graphene quantum dots synthesized from uric acid as single precursor[J]. Journal of Pharmaceutical Analysis, 2017, 7(5): 324-331.
Gema M. Durán, Tomás E. Benavidez, Ana M. Contento, Angel Ríos, Carlos D. García. Analysis of penicillamine using Cu-modified graphene quantum dots synthesized from uric acid as single precursor[J]. Journal of Pharmaceutical Analysis, 2017, 7(5): 324-331.
Citation:
Gema M. Durán, Tomás E. Benavidez, Ana M. Contento, Angel Ríos, Carlos D. García. Analysis of penicillamine using Cu-modified graphene quantum dots synthesized from uric acid as single precursor[J]. Journal of Pharmaceutical Analysis, 2017, 7(5): 324-331.
A simple methodology was developed to quantify penicillamine (PA) in pharmaceutical samples, using the selective interaction of the drug with Cu-modified graphene quantum dots (Cu-GQDs). The proposed strategy combines the advantages of carbon dots (over other nanoparticles) with the high affinity of PA for the proposed Cu-GQDs, resulting in a significant and selective quenching effect. Under the optimum conditions for the interaction, a linear response (in the 0.10–7.50 μmol/L PA concentration range) was observed. The highly fluorescent GQDs used were synthesized using uric acid as single precursor and then characterized by high resolution transmission electron microscopy, Raman spectroscopy, X-ray diffraction, Fourier transform infrared spectroscopy, fluorescence, and absorption spectroscopy. The proposed methodology could also be extended to other compounds, further expanding the applicability of GQDs.