Volume 7 Issue 5
Oct.  2017
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Gema M. Durán, Tomás E. Benavidez, Ana M. Contento, Angel Ríos, Carlos D. García. Analysis of penicillamine using Cu-modified graphene quantum dots synthesized from uric acid as single precursor[J]. Journal of Pharmaceutical Analysis, 2017, 7(5): 324-331.
Citation: Gema M. Durán, Tomás E. Benavidez, Ana M. Contento, Angel Ríos, Carlos D. García. Analysis of penicillamine using Cu-modified graphene quantum dots synthesized from uric acid as single precursor[J]. Journal of Pharmaceutical Analysis, 2017, 7(5): 324-331.

Analysis of penicillamine using Cu-modified graphene quantum dots synthesized from uric acid as single precursor

Funds:

This work was partially supported by the NIH–Research Centers at Minority Institutions

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Junta de Comunidades de Castilla-La Mancha, JCCM

Gema M. Durán thanks to MINECO of Spain for the predoctoral

  • Publish Date: Oct. 10, 2017
  • A simple methodology was developed to quantify penicillamine (PA) in pharmaceutical samples, using the selective interaction of the drug with Cu-modified graphene quantum dots (Cu-GQDs). The proposed strategy combines the advantages of carbon dots (over other nanoparticles) with the high affinity of PA for the proposed Cu-GQDs, resulting in a significant and selective quenching effect. Under the optimum conditions for the interaction, a linear response (in the 0.10–7.50 μmol/L PA concentration range) was observed. The highly fluorescent GQDs used were synthesized using uric acid as single precursor and then characterized by high resolution transmission electron microscopy, Raman spectroscopy, X-ray diffraction, Fourier transform infrared spectroscopy, fluorescence, and absorption spectroscopy. The proposed methodology could also be extended to other compounds, further expanding the applicability of GQDs.
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