Umar J. Pandit, Gowhar A. Naikoo, Mehraj Ud Din Sheikh, Gulzar A. Khan, K.K. Raj, S.N. Limaye. Electrochemical determination of an anti-hyperlipidimic drug pitavastatin at electrochemical sensor based on electrochemically pre-treated polymer film modified GCE[J]. Journal of Pharmaceutical Analysis, 2017, 7(4): 258-264.
Citation:
Umar J. Pandit, Gowhar A. Naikoo, Mehraj Ud Din Sheikh, Gulzar A. Khan, K.K. Raj, S.N. Limaye. Electrochemical determination of an anti-hyperlipidimic drug pitavastatin at electrochemical sensor based on electrochemically pre-treated polymer film modified GCE[J]. Journal of Pharmaceutical Analysis, 2017, 7(4): 258-264.
Umar J. Pandit, Gowhar A. Naikoo, Mehraj Ud Din Sheikh, Gulzar A. Khan, K.K. Raj, S.N. Limaye. Electrochemical determination of an anti-hyperlipidimic drug pitavastatin at electrochemical sensor based on electrochemically pre-treated polymer film modified GCE[J]. Journal of Pharmaceutical Analysis, 2017, 7(4): 258-264.
Citation:
Umar J. Pandit, Gowhar A. Naikoo, Mehraj Ud Din Sheikh, Gulzar A. Khan, K.K. Raj, S.N. Limaye. Electrochemical determination of an anti-hyperlipidimic drug pitavastatin at electrochemical sensor based on electrochemically pre-treated polymer film modified GCE[J]. Journal of Pharmaceutical Analysis, 2017, 7(4): 258-264.
Electrochemical determination of an anti-hyperlipidimic drug pitavastatin at electrochemical sensor based on electrochemically pre-treated polymer film modified GCE
Department of Chemistry, Harisingh Gour University, Sagar, M.P., India
Department of Mathematics and Sciences, College of Arts and Applied Sciences, Dofar University, Salalah, Oman
Funds:
The authors are highly grateful to UGC-SAP, SIC and Department of Chemistry, Dr. H.S.G., (Central) University, Sagar, India for provid-ing necessary lab facilities and required instrumentation
An electrochemically pretreated silver macroporous (Ag MP) multiwalled carbon nanotube modified glassy carbon electrode (PAN-Ag MP-MWCNT-GCE) was fabricated for the selective determination of an anti-hyperlipidimic drug, pitavastatin (PST). The fabricated electrochemical sensor was characterized by cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS). The fabricated electrode was employed in quantifying and determining PST through differential pulse adsorptive stripping voltammetry (DPAdSV) and CV. The electrode fabrication proceeded with remarkable sensitivity to the determination of PST. The effect of various optimized parameters such as pH, scan rate (ν), accumulation time (tacc), accumulation potential (Uacc) and loading volumes of Ag MP-MWCNT suspension were investigated to evaluate the performance of synthesized electrochemical sensor and to propose a simple, accurate, rapid and economical procedure for the quantification of PST in pharmaceutical formulations and biological fluids. A linear response of PST concentration in the range 2.0×10?7–1.6×10?6 M with low detection (LOD) and quantification (LOQ) limits of 9.66 ± 0.04 nM and 32.25 ± 0.07 nM, respectively, were obtained under these optimized conditions.