Nastaran Hashemzadeh, Mohammad Hasanzadeh, Nasrin Shadjou, Jamal Eivazi-Ziaei, Maryam Khoubnasabjafari, Abolghasem Jouyban. Graphene quantum dot modified glassy carbon electrode for the determination of doxorubicin hydrochloride in human plasma$[J]. Journal of Pharmaceutical Analysis, 2016, 6(4): 235-241.
Citation:
Nastaran Hashemzadeh, Mohammad Hasanzadeh, Nasrin Shadjou, Jamal Eivazi-Ziaei, Maryam Khoubnasabjafari, Abolghasem Jouyban. Graphene quantum dot modified glassy carbon electrode for the determination of doxorubicin hydrochloride in human plasma$[J]. Journal of Pharmaceutical Analysis, 2016, 6(4): 235-241.
Nastaran Hashemzadeh, Mohammad Hasanzadeh, Nasrin Shadjou, Jamal Eivazi-Ziaei, Maryam Khoubnasabjafari, Abolghasem Jouyban. Graphene quantum dot modified glassy carbon electrode for the determination of doxorubicin hydrochloride in human plasma$[J]. Journal of Pharmaceutical Analysis, 2016, 6(4): 235-241.
Citation:
Nastaran Hashemzadeh, Mohammad Hasanzadeh, Nasrin Shadjou, Jamal Eivazi-Ziaei, Maryam Khoubnasabjafari, Abolghasem Jouyban. Graphene quantum dot modified glassy carbon electrode for the determination of doxorubicin hydrochloride in human plasma$[J]. Journal of Pharmaceutical Analysis, 2016, 6(4): 235-241.
Hematology-0ncology Research Center, Tabriz University of Medical Sciences, Tabriz 51664, Iran
Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz 51664, Iran
Department of Nanochemistry, Nano Technology Research Center and Faculty of Chemistry Urmi
Tuberculosis and Lung Disease Research Center, Tabriz University of Medical Sciences, Tabriz 51664, Iran
Pharmaceutical Analysis Research Center and Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz 51664, Iran
Funds:
This work was a part of a Pharm. D thesis of N. Hashemzadeh. We gratefully acknowledge the partial financial support by the Hematology-Oncology Research Center, Tabriz University of Med-ical Sciences, under Grants No.93/5
Low toxic graphene quantum dot (GQD) was synthesized by pyrolyzing citric acid in alkaline solution and characterized by ultraviolet–visible (UV–vis) spectroscopy, X-ray diffraction (XRD), atomic force micro-scopy (AFM), spectrofluorimetery and dynamic light scattering (DLS) techniques. GQD was used for electrode modification and electro-oxidation of doxorubicin (DOX) at low potential. A substantial de-crease in the overvoltage ( ? 0.56 V) of the DOX oxidation reaction (compared to ordinary electrodes) was observed using GQD as coating of glassy carbon electrode (GCE). Differential pulse voltammetry was used to evaluate the analytical performance of DOX in the presence of phosphate buffer solution (pH 4.0) and good limit of detection was obtained by the proposed sensor. Such ability of GQD to promote the DOX electron-transfer reaction suggests great promise for its application as an electrochemical sensor.